Skip to main content Accessibility help
×
Home
Hostname: page-component-99c86f546-t82dr Total loading time: 2.211 Render date: 2021-11-28T21:45:47.745Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Chapter 15 - Epigenetics and Human Assisted Reproduction

Published online by Cambridge University Press:  24 December 2019

Kay Elder
Affiliation:
Bourn Hall Clinic, Cambridge
Brian Dale
Affiliation:
Centre for Assisted Reproduction, Naples
Get access

Summary

During mammalian development the growth of the fetus is regulated by genetic information that is inherited from both the sperm and the oocyte. Apart from the clear differences that are associated with the X and Y chromosomes, the parental genetic contributions to the embryo also differ via a system of ‘epigenetic’ marks. The differences in function between the parental genomes, how gametes and preimplantation embryos are reprogrammed, and how these delicate processes may be affected by ART and infertility will be described in this chapter. A full understanding of the cellular and molecular biology of human reproduction must include a study of epigenetics and genomic imprinting.

Type
Chapter
Information
In-Vitro Fertilization , pp. 331 - 357
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Amor, DJ, Halliday, J (2008) A review of known imprinting syndromes and their association with assisted reproduction technologies. Human Reproduction 23(12): 28262834.CrossRefGoogle ScholarPubMed
ASRM Practice Committee Pages (2013) Blastocyst culture and transfer in clinical assisted reproduction: a committee opinion. Fertility and Sterility 99(3): 00150282.
Gosden, R, Trasler, J, Lucifero, D, Faddy, M (2003) Rare congenital disorders, imprinted genes, and assisted reproductive technology. Lancet 361(9373): 19751977.CrossRefGoogle ScholarPubMed
Huntriss, J, Picton, HM (2008) Epigenetic consequences of assisted reproduction and infertility on the human preimplantation embryo. Human Fertility 11(2): 8594.CrossRefGoogle ScholarPubMed
Maher, ER, Afnan, M, Barratt, CL (2003) Epigenetic risks related to assisted reproductive technologies: epigenetics, imprinting, ART and icebergs? Human Reproduction 18(12): 25082511.CrossRefGoogle ScholarPubMed
Manipalviratn, S, DeCherney, A, Segars, J (2009) Imprinting disorders and assisted reproductive technology. Fertility and Sterility 91(2): 305315.CrossRefGoogle ScholarPubMed
Roseboom, TJ (2018) Developmental plasticity and its relevance to assisted human reproduction. Human Reproduction 33(4): 546552.CrossRefGoogle ScholarPubMed
Abeyta, MJ, Clark, AT, Rodriguez, RT, et al. (2004) Unique gene expression signatures of independently-derived human embryonic stem cell lines. Human Molecular Genetics 13: 601608.CrossRefGoogle ScholarPubMed
Adewumi, O, Aflatoonian, B, Ahrlund-Richter, L, et al. (2007) Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nature Biotechnology 25: 803816.Google ScholarPubMed
Albert, M, Peters, AH (2009) Genetic and epigenetic control of early mouse development. Current Opinion in Genetics and Development 19(2): 113121.CrossRefGoogle ScholarPubMed
Allegrucci, C, Wu, YZ, Thurston, A, et al. (2007) Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome. Human Molecular Genetics 16: 12531268.CrossRefGoogle ScholarPubMed
Anckaert, E, Adriaenssens, T, Romero, S, Dremier, S, Smitz, J (2009a) Unaltered imprinting establishment of key imprinted genes in mouse oocytes after in vitro follicle culture under variable follicle-stimulating hormone exposure. International Journal of Developmental Biology 53(4): 541548.CrossRefGoogle ScholarPubMed
Anckaert, E, Adriaenssens, T, Romero, S, Smitz, J (2009b) Ammonium accumulation and use of mineral oil overlay do not alter imprinting establishment at three key imprinted genes in mouse oocytes grown and matured in a long-term follicle culture. Biology of Reproduction 81(4): 666673.CrossRefGoogle ScholarPubMed
Anteby, I, Cohen, E, Anteby, E, BenEzra, D (2001) Ocular manifestations in children born after in vitro fertilization. Archives of Ophthalmology 119(10): 15251529.CrossRefGoogle ScholarPubMed
Aoki, VW, Emery, BR, Liu, L, Carrell, DT (2006a) Protamine levels vary between individual sperm cells of infertile human males and correlate with viability and DNA integrity. Journal of Andrology 27: 890898.CrossRefGoogle ScholarPubMed
Aoki, VW, Liu, L, Jones, KP, et al. (2006b) Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability. Fertility and Sterility 86: 14081415.CrossRefGoogle ScholarPubMed
Aoki, VW, Moskovtsev, SI, Willis, J, et al. (2005) DNA integrity is compromised in protamine-deficient human sperm. Journal of Andrology 26: 741748.CrossRefGoogle ScholarPubMed
Apostolidou, S, Abu-Amero, S, O’Donoghue, K, et al. (2007) Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight. Journal of Molecular Medicine 85: 379387.CrossRefGoogle ScholarPubMed
Aravin, AA, Hannon, GJ (2008) Small RNA silencing pathways in germ and stem cells. Cold Spring Harbor Symposia on Quantitative Biology 73: 283290.CrossRefGoogle ScholarPubMed
Aston, KI, Carrell, DT (2014) Prospects for clinically relevant epigenetic tests in the andrology laboratory. Asian Journal of Andrology 16(5): 782.CrossRefGoogle ScholarPubMed
Batcheller, A, Cardozo, E, Maguire, M, DeCherney, AH, Segars, JH (2011) Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies? Fertility and Sterility 96(6):13061311.CrossRefGoogle ScholarPubMed
Beaujean, N, Hartshorne, G, Cavilla, J, et al. (2004) Non-conservation of mammalian preimplantation methylation dynamics. Current Biology 14(7): R266–267.CrossRefGoogle ScholarPubMed
Bell, AC, Felsenfeld, G (2000) Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405(6785): 482485.CrossRefGoogle ScholarPubMed
Benchaib, M, Braun, V, Ressnikof, D, et al. (2005) Influence of global sperm DNA methylation on IVF results. Human Reproduction 20: 768773.CrossRefGoogle ScholarPubMed
Bliek, J, Terhal, P, van den Bogaard, MJ, et al. (2006) Hypomethylation of the H19 gene causes not only Silver–Russell syndrome (SRS) but also isolated asymmetry or an SRS-like phenotype. American Journal of Human Genetics 78: 604614.CrossRefGoogle Scholar
Blondin, P, Farin, PW, Crosier, AE, Alexander, JE, Farin, CE (2000) In vitro production of embryos alters levels of insulin-like growth factor-II messenger ribonucleic acid in bovine fetuses 63 days after transfer. Biology and Reproduction 62(2): 384389.CrossRefGoogle ScholarPubMed
Boissonnas, CC, Abdalaoui, HE, Haelewyn, V, et al. (2010) Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men. European Journal of Human Genetics 18(1): 7380.CrossRefGoogle ScholarPubMed
Boissonnas, CC, Jouannet, P, Jammes, H (2013). Epigenetic disorders and male subfertility. Fertility and Sterility 99(3): 624631.CrossRefGoogle ScholarPubMed
Boonen, SE, Porksen, S, Mackay, DJ, et al. (2008) Clinical characterisation of the multiple maternal hypomethylation syndrome in siblings. European Journal of Human Genetics 16: 453461.CrossRefGoogle ScholarPubMed
Borghol, N, Blachère, T, Lefèvre, A (2008) Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatid injection into mouse oocytes. Genomics 91(5): 415422.CrossRefGoogle ScholarPubMed
Borghol, N, Lornage, J, Blachere, T, Sophie Garret, A, Lefevre, A (2006) Epigenetic status of the H19 locus in human oocytes following in vitro maturation. Genomics 87: 417426.CrossRefGoogle ScholarPubMed
Bourc’his, D, Xu, GL, Lin, CS, Bollman, B, Bestor, TH (2001) Dnmt3L and the establishment of maternal genomic imprints. Science 294(5551): 25362539.CrossRefGoogle ScholarPubMed
Bourque, DK, Avila, L, Peñaherrera, M, von Dadelszen, P, Robinson, WP (2010) Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia. Placenta 31(3): 197202.CrossRefGoogle Scholar
Camprubi, C, Iglesias-Platas, I, Martin-Trujillo, A, et al. (2013) Stability of genomic imprinting and gestational-age dynamic methylation in complicated pregnancies conceived following assisted reproductive technologies. Biology of Reproduction 89(3): 50.CrossRefGoogle ScholarPubMed
Carlone, DL, Lee, JH, Young, SR, et al. (2005) Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein. Molecular and Cellular Biology 25(12): 48814891.CrossRefGoogle ScholarPubMed
Carlone, DL, Skalnik, DG (2001) CpG binding protein is crucial for early embryonic development. Molecular and Cellular Biology 21(22): 76017606.CrossRefGoogle ScholarPubMed
Carrasco, B, Boada, M, Rodriguez, I, Coroleu, B, Barri, PN, Veiga, A (2013) Does culture medium influence offspring birth weight? Fertility and Sterility 100(5): 12831288.CrossRefGoogle ScholarPubMed
Carrell, DT (2012) Epigenetics of the male gamete. Fertility and Sterility 97(2): 267274.CrossRefGoogle ScholarPubMed
Carrell, DT, Emery, BR, Hammoud, S (2007) Altered protamine expression and diminished spermatogenesis: what is the link? Human Reproduction Update 13: 313327.CrossRefGoogle ScholarPubMed
Cetin, I, Cozzi, V, Antonazzo, P (2003) Fetal development after assisted reproduction – a review. Placenta 24(Suppl. B): S104–113.CrossRefGoogle ScholarPubMed
Chang, AS, Moley, KH, Wangler, M, Feinberg, AP, Debaun, MR (2005) Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertility and Sterility 83: 349354.CrossRefGoogle ScholarPubMed
Charalambous, M, Ferron, SR, da Rocha, ST, et al. (2012) Imprinted gene dosage is critical for the transition to independent life. Cell Metabolism 15(2): 209221.CrossRefGoogle ScholarPubMed
Chatterjee, A, Saha, D, Niemann, H, Gryshkov, O, Gismacher, B, Hofmann, N (2017) Effects of cryopreservation on the epigenetic profile of cells. Cryobiology 74: 17.CrossRefGoogle Scholar
Chen, Z, Hagen, DE, Elsik, CG, et al. (2015) Characterization of global loss of imprinting in fetal overgrowth syndrome induced by assisted reproduction. Proceedings of the National Academy of Sciences of the USA 112(15): 46184623.CrossRefGoogle ScholarPubMed
Chen, Q, Yan, M, Cao, Z, et al. (2016) Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 351(6271): 397400.CrossRefGoogle ScholarPubMed
Chen, H, Zhang, L, Deng, T, et al. (2016) Effects of oocyte vitrification on epigenetic status in early bovine embryos. Theriogenology 86(3): 868878.CrossRefGoogle ScholarPubMed
Cheng, KR, Fu, XW, Zhang, RN, Jia, GX, Hou, YP, Zhu, SE (2014) Effect of oocyte vitrification on deoxyribonucleic acid methylation of H19, Peg3, and Snrpn differentially methylated regions in mouse blastocysts. Fertility and Sterility 102(4): 11831190.CrossRefGoogle ScholarPubMed
Chopra, M, Amor, DJ, Sutton, L, Algar, E, Mowat, D (2010) Russell-Silver syndrome due to paternal H19/IGF2 hypomethylation in a patient conceived using intracytoplasmic sperm injection. Reproductive Biomedicine Online 20(6): 843847.CrossRefGoogle Scholar
Chotalia, M, Smallwood, SA, Ruf, N, et al. (2009) Transcription is required for establishment of germline methylation marks at imprinted genes. Genes and Development 23(1): 105117.CrossRefGoogle ScholarPubMed
Choufani, S, Turinsky, AL, Melamed, N, et al. (2018) Impact of assisted reproduction, infertility, sex, and paternal factors on the placental DNA methylome. Human Molecular Genetics 28(3): 372385.CrossRefGoogle Scholar
Ciccone, DN, Su, H, Hevi, S, et al. (2009) KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature 461(7262): 415418.CrossRefGoogle ScholarPubMed
Coan, PM, Burton, GJ, Ferguson-Smith, AC (2005) Imprinted genes in the placenta; a review. Placenta 26: S10–20.CrossRefGoogle ScholarPubMed
Constância, M, Pickard, B, Kelsey, G, Reik, W (1998) Imprinting mechanisms. Genome Research 8(9): 881900.CrossRefGoogle ScholarPubMed
Corry, GN, Tanasijevic, B, Barry, ER, Krueger, W, Rasmussen, TP (2009) Epigenetic regulatory mechanisms during preimplantation development. Birth Defects Research Part C Embryo Today 87(4): 297313.CrossRefGoogle ScholarPubMed
Cox, GF, Burger, J, Lip, V, et al. (2002) Intracytoplasmic sperm injection may increase the risk of imprinting defects. American Journal of Human Genetics 1(1): 162164.CrossRefGoogle Scholar
Dahl, JA, Reiner, AH, Klungland, A, Wakayama, T, Collas, P (2010) Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos. PLoS One 5(2): e9150.CrossRefGoogle ScholarPubMed
DeBaun, MR, Niemitz, EL, Feinberg, AP (2003) Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. American Journal of Human Genetics 72: 156160.CrossRefGoogle ScholarPubMed
De Munck, N, Petrussa, L, Verheyen, G, et al. (2015) Chromosomal meiotic segregation, embryonic developmental kinetics and DNA (hydroxy)methylation analysis consolidate the safety of human oocyte vitrification. Molecular Human Reproduction 21(6): 535544.CrossRefGoogle ScholarPubMed
Denomme, MM, Mann, MR (2012) Genomic imprints as a model for the analysis of epigenetic stability during assisted reproductive technologies. Reproduction 144(4): 393409.CrossRefGoogle ScholarPubMed
Denomme, MM, McCallie, BR, Parks, JC, Schoolcraft, WB, Katz-Jaffe, MG (2017) Alterations in the sperm histone retained epigenome are associated with unexplained male factor infertility and poor blastocyst development in donor oocyte IVF cycles. Human Reproduction 32(12): 24432455.CrossRefGoogle ScholarPubMed
Denomme, MM, Zhang, L, Mann, MR (2011) Embryonic imprinting perturbations do not originate from superovulation-induced defects in DNA methylation acquisition. Fertility and Sterility 96(3): 734–738.e2.CrossRefGoogle Scholar
de Castro Barbosa, T, Ingerslev, LR, Alm, PS, et al. (2016) High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Molecular Metabolism 5(3): 184197.CrossRefGoogle ScholarPubMed
De Vos, A, Janssens, R, Van de Velde, H, et al. (2015) The type of culture medium and the duration of in vitro culture do not influence birthweight of ART singletons. Human Reproduction 30(1): 2027.CrossRefGoogle Scholar
Derakhshan-Horeh, M, Abolhassani, F, Jafarpour, F, et al. (2016) Vitrification at Day 3 stage appears not to affect the methylation status of H19/IGF2 differentially methylated region of in vitro produced human blastocysts. Cryobiology 73(2): 168174.CrossRefGoogle Scholar
Doherty, AS, Mann, MR, Tremblay, KD, Bartolomei, MS, Schultz, RM (2000) Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biology of Reproduction 62(6): 15261535.CrossRefGoogle ScholarPubMed
Doornbos, ME, Maas, SM, McDonnell, J, Vermeiden, JP, Hennekam, RC (2007) Infertility, assisted reproduction technologies and imprinting disturbances: a Dutch study. Human Reproduction 22: 24762480.CrossRefGoogle ScholarPubMed
Dumoulin, JC, Land, JA, Van Montfoort, AP, et al. (2010) Effect of in vitro culture of human embryos on birthweight of newborns. Human Reproduction 25(3): 605612.CrossRefGoogle ScholarPubMed
Eggermann, T, Perez de Nanclares, G, Maher, ER, et al. (2015) Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci. Clinical Epigenetics 7: 123.CrossRefGoogle ScholarPubMed
Eskld, A, Monkerud, L, Tanbo, T (2013) Birthweight and placental weight; do changes in culture media used for IVF matter? Comparisons with spontaneous pregnancies in the corresponding time periods. Human Reproduction 28(12): 32073214.CrossRefGoogle Scholar
Fauque, P (2013) Superovulation: ovulation induction and epigenetic anomalies. Fertility and Sterility 99(3): 616623.CrossRefGoogle Scholar
Fauque, P, Jouannet, P, Lesaffre, C, et al. (2007) Assisted reproductive technology affects developmental kinetics, H19 imprinting control region methylation and H19 gene expression in individual mouse embryos. BMC Developmental Biology 7: 116.CrossRefGoogle ScholarPubMed
Fauque, P, Mondon, F, Letourneur, F, et al. (2010b) In vitro fertilization and embryo culture strongly impact the placental transcriptome in the mouse model. PLoS One 5(2): e9218.CrossRefGoogle ScholarPubMed
Fauque, P, Ripoche, MA, Tost, J, et al. (2010a) Modulation of imprinted gene network in placenta results in normal development of in vitro manipulated mouse embryos. Human Molecular Genetics 19(9): 17791790CrossRefGoogle ScholarPubMed
Fenic, I, Hossain, HM, Sonnack, V, et al. (2008) In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. Journal of Andrology 29: 172185.CrossRefGoogle ScholarPubMed
Fenic, I, Sonnack, V, Failing, K, Bergmann, M, Steger, K (2004) In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis Journal of Andrology 25: 811818.CrossRefGoogle ScholarPubMed
Fernandez-Gonzalez, R, Moreira, P, Bilbao, A, et al. (2004) Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior. Proceedings of the National Academy of Sciences of the USA 101: 58805885.CrossRefGoogle Scholar
Fortier, AL, Lopes, FL, Darricarrère, N, Martel, J, Trasler, JM (2008) Superovulation alters the expression of imprinted genes in the midgestation mouse placenta. Human Molecular Genetics 17(11): 16531665.CrossRefGoogle ScholarPubMed
Fortier, AL, McGraw, S, Lopes, FL, et al. (2014) Modulation of imprinted gene expression following superovulation. Molecular and Cellular Endocrinology 388(1–2): 5157.CrossRefGoogle ScholarPubMed
Frost, RJ, Hamra, FK, Richardson, JA, Qi, X, BAssel-Duby, R, Olson, EN (2010) MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proceedings of the National Academy of Sciences of the USA 107: 1184711852.CrossRefGoogle ScholarPubMed
Gad, A, Schellander, K, Hoelker, M, Tesfaye, D (2012) Transcriptome profile of early mammalian embryos in response to culture environment. Animal Reproduction Science 134(1–2): 7683.CrossRefGoogle ScholarPubMed
Galli-Tsinopoulou, A, Emmanouilidou, E, Karagianni, P, et al. (2008) A female infant with Silver Russell Syndrome, mesocardia and enlargement of the clitoris. Hormones (Athens) 7: 7781.CrossRefGoogle ScholarPubMed
Gardner, DK, Kelly, RL (2017) Impact of the IVF laboratory environment on human preimplantation embryo phenotype. Journal of Developmental Origins of Health and Disease 8(4): 418435.CrossRefGoogle ScholarPubMed
Ge, ZJ, Liang, QX, Hou, Y, et al. (2014) Maternal obesity and diabetes may cause DNA methylation alteration in the spermatozoa of offspring in mice. Reproductive Biology and Endocrinology 12: 29.CrossRefGoogle ScholarPubMed
Geuns, E, De Rycke, M, Van Steirteghem, A, Leibaers, I (2003) Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos. Human Molecular Genetics 12(22): 28732879.CrossRefGoogle ScholarPubMed
Ghosh, J, Coutifaris, C, Sapienza, C, Mainigi, M (2017) Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies. Clinical Epigenetics 9: 14.CrossRefGoogle ScholarPubMed
Gicquel, C, Gaston, V, Mandelbaum, J, et al. (2003) In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. American Journal of Human Genetics 72: 1338.CrossRefGoogle ScholarPubMed
Ginsburg, M, Snow, MH, McLaren, A (1990) Primordial germ cells in the mouse embryo during gastrulation. Development 110: 521528.Google ScholarPubMed
Gomes, MV, Huber, J, Ferriani, RA, Amaral Neto, AM, Ramos, ES (2009) Abnormal methylation at the KvDMR1 imprinting control region in clinically normal children conceived by assisted reproductive technologies. Molecular and Human Reproduction 15(8): 471477.CrossRefGoogle ScholarPubMed
Gross, N, Kroop, J, Khatib, H (2017) MicroRNA signaling in embryo development. Biology (Basel) 6(3): pii:E34.Google ScholarPubMed
Guo, H, Zhu, P, Yan, L, et al. (2014) The DNA methylation landscape of human early embryos. Nature 511: 606610.CrossRefGoogle ScholarPubMed
Halliday, J, Oke, K, Breheny, S, Algar, EJ Amor, D (2004) Beckwith-Wiedemann syndrome and IVF: a case-control study. American Journal of Human Genetics 75: 526528.CrossRefGoogle ScholarPubMed
Hammoud, SS, Purwar, J, Pflueger, C, Cairns, BR, Carrell, DT (2010) Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility. Fertility and Sterility 94(5): 17281733.CrossRefGoogle ScholarPubMed
Hammoud, SS, Nix, DA, Hammoud, AO, Gibson, M, Cairns, BR, Carrell, DT (2011) Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men. Human Reproduction 26: 25582569.CrossRefGoogle ScholarPubMed
Hammoud, SS, Nix, DA, Zhang, H, Purwar, K, Carrell, DT, Cairns, BR (2009) Distinctive chromatin in human sperm packages genes for embryo development. Nature 460: 473478.CrossRefGoogle ScholarPubMed
Hata, K, Okano, M, Lei, H, Li, E (2002) Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129(8): 19831993.Google ScholarPubMed
Hayashi, S, Yang, J, Christenson, L, Yanagimachi, R, Hecht, NB (2003) Mouse preimplantation embryos developed from oocytes injected with round spermatids or spermatozoa have similar but distinct patterns of early messenger RNA expression. Biology of Reproduction 69: 11701176.CrossRefGoogle ScholarPubMed
Hiendleder, S, Mund, C, Reichenbach, HD, et al. (2004) Tissue-specific elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques. Biology of Reproduction 71(1): 217223.CrossRefGoogle ScholarPubMed
Hill, PW, Amouroux, R, Hajkova, P (2014) DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: an emerging complex story. Genomics 104(5): 324333.CrossRefGoogle ScholarPubMed
Hirasawa, R, Chiba, H, Kaneda, M, et al. (2008) Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes and Development 22(12): 16071616.CrossRefGoogle ScholarPubMed
Hiura, H, Obata, Y, Komiyama, J, Shirai, M, Kono, T (2006) Oocyte growth-dependent progression of maternal imprinting in mice. Genes to Cells 11(4): 353361.CrossRefGoogle ScholarPubMed
Hiura, H, Okae, H, Chiba, H, et al. (2014) Imprinting methylation errors in ART. Reproductive Medicine and Biology 13(4): 193202.CrossRefGoogle ScholarPubMed
Hiura, H, Okae, H, Miyauchi, N, et al. (2012) Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. Human Reproduction 27(8): 25412548.CrossRefGoogle ScholarPubMed
Holm, TM, Jackson-Grusby, L, Brambrink, T, et al. (2005) Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell 8: 275285.CrossRefGoogle ScholarPubMed
Hotaling, J, Carrell, DT (2014) Clinical genetic testing for male factor infertility: current applications and future directions. Andrology 2(3): 339350.CrossRefGoogle ScholarPubMed
Houshdaran, S, Cortessis, VK, Siegmund, K, et al. (2007) Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One 2(12): e1289.CrossRefGoogle ScholarPubMed
Huffman, SR, Pak, Y, Rivera, RM (2015) Superovulation induces alterations in the epigenome of zygotes, and results in differences in gene expression at the blastocyst stage in mice. Molecular Reproduction and Development 82(3): 207217.CrossRefGoogle ScholarPubMed
Huntriss, J (2011) Epigenetics and assisted reproduction. In: Elder, K, Dale, B (eds.) In-Vitro Fertilization, 3rd edn. Cambridge University Press, Cambridge, UK, pp. 252267.Google Scholar
Huntriss, J, Balen, AH, Sinclair, KD, Brison, DR, Picton, HM; Royal College of Obstetricians Gynaecologists (2018) Epigenetics and Reproductive Medicine: Scientific Impact Paper No. 57. BJOG 125(13): e43e54.CrossRefGoogle ScholarPubMed
Huntriss, JD, Hemmings, KE, Hinkins, M, et al. (2013) Variable imprinting of the MEST gene in human preimplantation embryos. European Journal of Human Genetics 21(1): 4047.CrossRefGoogle ScholarPubMed
Huntriss, J, Picton, HM (2008) Epigenetic consequences of assisted reproduction and infertility on the human preimplantation embryo. Human Fertility (Cambridge) 11(2): 8594.CrossRefGoogle ScholarPubMed
Ibala-Romdhane, S, Al-Khtib, M, Khoueiry, R, Blachére, T, Guerin, JF, Lefévre, A (2011) Analysis of H19 methylation in control and abnormal human embryos, sperm and oocytes. European Journal of Human Genetics 19(11): 11381143.CrossRefGoogle ScholarPubMed
Imamura, T, Kerjean, A, Heams, T, et al. (2005) Dynamic CpG and non-CpG methylation of the Peg1/Mest gene in the mouse oocyte and preimplantation embryo. Journal of Biological Chemistry 280: 2017120175.CrossRefGoogle ScholarPubMed
Isles, AR, Holland, AJ (2005) Imprinted genes and mother-offspring interactions. Early Human Development 81: 7377.CrossRefGoogle ScholarPubMed
Jenkins, TG, Aston, KI, Pflueger, C, Cairns, BR, Carrell, DT (2014) Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genetics 10(7): e1004458.CrossRefGoogle ScholarPubMed
Jenkins, TG, James, ER, Alonso, DF, et al. (2017) Cigarette smoking significantly alters sperm DNA methylation patterns. Andrology 5(6): 10891099.CrossRefGoogle ScholarPubMed
Johnson, JP, Schoof, J, Beischel, L, et al. (2018) Detection of a case of Angelman syndrome caused by an imprinting error in 949 pregnancies analyzed for AS following IVF. Journal of Assisted Reproduction and Genetics 35(6): 981984.CrossRefGoogle ScholarPubMed
Kagami, M, Nagai, T, Fukami, M, Yamazawa, K, Ogata, T (2007) Silver-Russell syndrome in a girl born after in vitro fertilization: partial hypermethylation at the differentially methylated region of PEG1/MEST. Journal of Assisted Reproduction and Genetics 24: 131136.CrossRefGoogle Scholar
Källén, B, Finnström, O, Lindam, A, et al. (2010) Congenital malformations in infants born after in vitro fertilization in Sweden. Birth Defects Research A: Clinical and Molecular Teratology 88(3): 137143.Google ScholarPubMed
Källén, B, Finnström, O, Nygren, KG, Olausson, PO (2005) In vitro fertilization (IVF) in Sweden: infant outcome after different IVF fertilization methods. Fertility and Sterility 84: 611617.CrossRefGoogle ScholarPubMed
Kanber, D, Berulava, T, Ammerpohl, O, et al. (2009a) The human retinoblastoma gene is imprinted. PLoS Genetics 5(12): e1000790.CrossRefGoogle ScholarPubMed
Kanber, D, Buiting, K, Zeschnigk, M, Ludwig, M, Horsthemke, B (2009b) Low frequency of imprinting defects in ICSI children born small for gestational age. European Journal of Human Genetics 17(1): 2229.CrossRefGoogle ScholarPubMed
Kerjean, A, Couvert, P, Heams, T, et al. (2003) In vitro follicular growth affects oocyte imprinting establishment in mice. European Journal of Human Genetics 11: 493496.CrossRefGoogle ScholarPubMed
Khosla, S, Dean, W, Brown, D, Reik, W, Feil, R (2001) Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biology of Reproduction 64: 918926.CrossRefGoogle ScholarPubMed
Khoueiry, R, Ibala-Rhomdane, S, Al-Khtib, M, et al. (2012) Abnormal methylation of KCNQ1OT1 and differential methylation of H19 imprinting control regions in human ICSI embryos. Zygote 21: 110.Google ScholarPubMed
Khoueiry, R, Ibala-Rhomdane, S, Méry, L, et al. (2008) Dynamic CpG methylation of the KCNQ1OT1 gene during maturation of human oocytes. Journal of Medical Genetics 45(9): 583588.CrossRefGoogle ScholarPubMed
Kim, KP, Thurston, A, Mummery, C, et al. (2007) Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines. Genome Research 17: 17311742.CrossRefGoogle ScholarPubMed
Kimber, SJ, Sneddon, SF, Bloor, DJ, et al. (2008) Expression of genes involved in early cell fate decisions in human embryos and their regulation by growth factors. Reproduction 135(5): 635647.CrossRefGoogle ScholarPubMed
Kishigami, S, Van Thuan, N, Hikichi, T, et al. (2006) Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. Developmental Biology 289: 195205.CrossRefGoogle ScholarPubMed
Klaver, R, Gromoll, J (2014) Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives. Asian Journal of Andrology 16(5): 669674.Google Scholar
Kleijkers, SH, Eijssen, LM, Coonen, E, et al.(2015a) Differences in gene expression profiles between human preimplantation embryos cultured in two different IVF culture media. Human Reproduction 30(10): 23032311.CrossRefGoogle ScholarPubMed
Kleijkers, SH, van Montfoort, AP, Smits, LJ, et al. (2015b) Age of G-1 PLUS v5 embryo culture medium is inversely associated with birthweight of the newborn. Human Reproduction 30(6): 13521357.CrossRefGoogle ScholarPubMed
Kobayashi, H, Hiura, H, John, RM, et al. (2009) DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. European Journal of Human Genetics 17(12): 15821591.CrossRefGoogle ScholarPubMed
Kobayashi, H, Sato, A, Otsu, E, et al. (2007) Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients. Human Molecular Genetics 16: 25422551.CrossRefGoogle ScholarPubMed
Kono, T (2009) Genetic modification for bimaternal embryo development. Reproduction and Fertility Development 21(1): 3136.CrossRefGoogle ScholarPubMed
Kurihara, Y, Kawamura, Y, Uchijima, Y, et al. (2008) Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1. Developmental Biology 313(1): 335346.CrossRefGoogle ScholarPubMed
Lane, M, Gardner, DK (1994) Increase in postimplantation development of cultured mouse embryos by amino acids and induction of fetal retardation and exencephaly by ammonium ions. Journal of Reproduction & Fertility 102(2): 305312.CrossRefGoogle ScholarPubMed
Lane, M, Gardner, DK (2003) Ammonium induces aberrant blastocyst differentiation, metabolism, pH regulation, gene expression and subsequently alters fetal development in the mouse. Biology of Reproduction 69: 11091117.CrossRefGoogle ScholarPubMed
Lazaraviciute, G, Kauser, M, Bhattacharya, S, Haggarty, P (2014) A systematic review and meta-analysis of DNA methylation levels and imprinting disorders in children conceived by IVF/ICSI compared with children conceived spontaneously. Human Reproduction Update 20(6): 840852.CrossRefGoogle ScholarPubMed
Lee, I, Finger, PT, Grifo, JA, et al. (2004) Retinoblastoma in a child conceived by in vitro fertilisation. British Journal of Ophthalmology 88(8): 10981099.CrossRefGoogle Scholar
Lee, MG, Wynder, C, Cooch, N, Shiekhattar, R (2005) An essential role for CoREST in nucleosomal histone-3-lysine-4 demethylation. Nature 437: 432435.CrossRefGoogle ScholarPubMed
Lee, YS, Latham, KE, Vandevoort, CA (2008) Effects of in vitro maturation on gene expression in rhesus monkey oocytes. Physiological Genomics 35(2): 145158.CrossRefGoogle ScholarPubMed
Lees-Murdock, DJ, Lau, HT, Castrillon, DH, De Felici, M, Walsh, CP (2008) DNA methyltransferase loading, but not de novo methylation, is an oocyte-autonomous process stimulated by SCF signalling. Developmental Biology 321(1): 238250.CrossRefGoogle Scholar
Lees-Murdock, DJ, Walsh, CP (2008) DNA methylation reprogramming in the germ line. Advances in Experimental Medicine and Biology 626: 115.CrossRefGoogle ScholarPubMed
Li, G, Yu, Y, Fan, Y, et al. (2017) Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology. Journal of Genetics and Genomics 44(10): 475481.CrossRefGoogle ScholarPubMed
Li, T, Vu, TH, Ulaner, GA, et al. (2005) IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch. Molecular Human Reproduction 11: 631640.CrossRefGoogle ScholarPubMed
Li, X, Ito, M, Zhou, F, et al. (2008) A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Developmental Cell 15(4): 547557.CrossRefGoogle ScholarPubMed
Liang, XW, Zhu, JQ, Miao, YL, et al. (2008) Loss of methylation imprint of Snrpn in postovulatory aging mouse oocyte. Biochemical and Biophysical Research Communications 371(1): 1621.CrossRefGoogle ScholarPubMed
Liang, Y, Fu, XW, Li, JJ, Yuan, DS, Zhu, SE (2014) DNA methylation pattern in mouse oocytes and their in vitro fertilized early embryos: effect of oocyte vitrification. Zygote 22(2): 138145.CrossRefGoogle ScholarPubMed
Lim, D, Bowdin, SC, Tee, L, et al. (2009) Clinical and molecular genetic features of Beckwith-Wiedemann syndrome associated with assisted reproductive technologies. Human Reproduction 24(3): 741747.CrossRefGoogle ScholarPubMed
Lin, S, Li, M, Lian, Y, Chen, L, Liu, P (2013) No effect of embryo culture media on birthweight and length of newborns. Human Reproduction 28(7): 17621767.CrossRefGoogle ScholarPubMed
Lucifero, D, La Salle, S, Bourc’his, D, et al. (2007) Coordinate regulation of DNA methyltransferase expression during oogenesis. BMC Developmental Biology 7: 36.CrossRefGoogle ScholarPubMed
Lucifero, D, Mann, MR, Bartolomei, MS, Trasler, JM (2004) Gene-specific timing and epigenetic memory in oocyte imprinting. Human Molecular Genetics 13(8): 839849.CrossRefGoogle ScholarPubMed
Ludwig, M, Katalinic, A, Gross, S, et al. (2005) Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples. Journal of Medical Genetics 42: 289291.CrossRefGoogle ScholarPubMed
Luedi, PP, Dietrich, FS, Weidman, JR, et al. (2007) Computational and experimental identification of novel human imprinted genes. Genome Research 17(12): 17231730.CrossRefGoogle ScholarPubMed
Maas, K, Galinka, E, Thornton, K, Penzias, AS, Sakkas, D (2016) No change in live birthweight of IVF singleton deliveries over an 18-year period despite significant clinical and laboratory changes. Human Reproduction 31(9): 19871996.CrossRefGoogle ScholarPubMed
Mackay, DJ, Boonen, SE, Clayton-Smith, J, et al. (2006) A maternal hypomethylation syndrome presenting as transient neonatal diabetes mellitus. Human Genetics 120: 262269.CrossRefGoogle ScholarPubMed
Maher, ER, Brueton, LA, Bowdin, SC, et al. (2003) Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). Journal of Medical Genetics 40: 6264.CrossRefGoogle Scholar
Maher, ER, Reik, W (2000) Beckwith-Wiedemann syndrome: imprinting in clusters revisited. Journal of Clinical Investigation 105(3): 247252.CrossRefGoogle ScholarPubMed
Mainigi, MA, Sapienza, C, Butts, S, Coutifaris, C (2016) A molecular perspective on procedures and outcomes with assisted reproductive technologies. Cold Spring Harbor Perspectives in Medicine 6(4): a023416.CrossRefGoogle ScholarPubMed
Malter, HE, Cohen, J (2002) Ooplasmic transfer: animal models assist human studies. Reproductive Biomedicine Online 5(1): 2635.CrossRefGoogle ScholarPubMed
Mann, MR, Lee, SS, Doherty, AS, et al. (2004) Selective loss of imprinting in the placenta following preimplantation development in culture. Development 131: 37273735.CrossRefGoogle ScholarPubMed
Manning, M, Lissens, W, Bonduelle, M, et al. (2000) Study of DNA-methylation patterns at chromosome 15q11-q13 in children born after ICSI reveals no imprinting defects. Molecular Human Reproduction 6: 10491053.CrossRefGoogle ScholarPubMed
Manning, M, Lissens, W, Liebaers, I, Van Steirteghem, A, Weidner, W (2001a) Imprinting analysis in spermatozoa prepared for intracytoplasmic sperm injection (ICSI). International Journal of Andrology 24(2): 8794.CrossRefGoogle Scholar
Manning, M, Lissens, W, Weidner, W, Liebaers, I (2001b) DNA methylation analysis in immature testicular sperm cells at different developmental stages. Urology International 67(2): 151155.CrossRefGoogle ScholarPubMed
Mantikou, E, Jonker, MJ, Wong, KM, et al. (2016) Factors affecting the gene expression of in vitro cultured human preimplantation embryos. Human Reproduction 31(2): 298311.Google ScholarPubMed
Marees, T, Dommering, CJ, Imhof, SM, et al. (2009) Incidence of retinoblastoma in Dutch children conceived by IVF: an expanded study. Human Reproduction 24(12): 32203224.CrossRefGoogle Scholar
Market-Velker, BA, Fernandes, AD, Mann, MR (2010) Side-by-side comparison of five commercial media systems in a mouse model: suboptimal in vitro culture interferes with imprint maintenance. Biology of Reproduction 83(6): 938950.CrossRefGoogle Scholar
Market-Velker, BA, Zhang, L, Magri, LS, Bonvissuto, AC, Mann, MR (2010) Dual effects of superovulation: loss of maternal and paternal imprinted methylation in a dose-dependent manner. Human Molecular Genetics 19(1): 3651.CrossRefGoogle ScholarPubMed
Marques, CJ, Carvalho, F, Sousa, M, Barros, A (2004) Genomic imprinting in disruptive spermatogenesis. Lancet 363: 17001702.CrossRefGoogle ScholarPubMed
Marques, CJ, Costa, P, Vaz, B, et al. (2008) Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia. Molecular Human Reproduction 14(2): 6774.CrossRefGoogle ScholarPubMed
Marques, CJ, Francisco, T, Sousa, S, et al. (2010) Methylation defects of imprinted genes in human testicular spermatozoa. Fertility and Sterility 94(2): 585594.CrossRefGoogle ScholarPubMed
McMinn, J, Wei, M, Schupf, N, et al. (2006) Unbalanced placental expression of imprinted genes in human intrauterine growth restriction. Placenta 27: 540549.CrossRefGoogle ScholarPubMed
Melamed, N, Choufani, S, Wilkins-Haug, LE, Koren, G, Weksberg, R (2015) Comparison of genome-wide and gene-specific DNA methylation between ART and naturally conceived pregnancies. Epigenetics 10(6): 474483.CrossRefGoogle ScholarPubMed
Ménézo, Y, Elder, K, Benkhalifa, M, Dale, B (2010) DNA methylation and gene expression in IVF. Reproductive Biomedicine Online 20(6): 709710.CrossRefGoogle ScholarPubMed
Ménézo, Y, Dale, B, Elder, K (2018) Time to re-evaluate ART protocols in the light of advances in knowledge about methylation and epigenetics: an opinion paper. Human Fertility (Cambridge) 21(3): 156162.CrossRefGoogle Scholar
Meschede, D, De Geyter, C, Nieschlag, E, Horst, J (1995) Genetic risk in micromanipulative assisted reproduction. Human Reproduction 10: 28802886.CrossRefGoogle ScholarPubMed
Moll, AC, Imhof, SM, Cruysberg, JR, et al. (2003) Incidence of retinoblastoma in children born after in-vitro fertilisation. Lancet 361(9354): 309310.CrossRefGoogle ScholarPubMed
Monk, M, Boubelik, M, Lehnert, S (1987) Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99(3): 371382.Google ScholarPubMed
Moore, T, Haig, D (1991) Genomic imprinting in mammalian development: a parental tug of war. Trends in Genetics 7: 4549.CrossRefGoogle ScholarPubMed
Morgan, HD, Santos, F, Green, K, Dean, W, Reik, W (2005) Epigenetic reprogramming in mammals. Human Molecular Genetics 14(Spec No 1): R47–58.CrossRefGoogle ScholarPubMed
Morison, IM, Ramsay, JP, Spencer, HG (2005) A census of mammalian imprinting. Trends in Genetics 21: 457465.CrossRefGoogle ScholarPubMed
Morison, IM, Reeve, AE (1998) A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Human Molecular Genetics 7: 15991609.CrossRefGoogle ScholarPubMed
Mussa, A, Molinatto, C, Cerrato, F, et al. (2017) Assisted reproductive techniques and risk of Beckwith-Wiedemann Syndrome Pediatrics 140(1): pii e20164311.CrossRefGoogle ScholarPubMed
Nakamura, T, Arai, Y, Umehara, H, et al. (2007) PGC7/Stella protects against DNA demethylation in early embryogenesis. Nature Cell Biology 9(1): 6471.CrossRefGoogle ScholarPubMed
Nelissen, EC, Van Montfoort, AP, Coonen, E, et al. (2012) Further evidence that culture media affect perinatal outcome: findings after transfer of fresh and cryopreserved embryos. Human Reproduction 27(7): 19661976.CrossRefGoogle ScholarPubMed
Obata, Y, Kaneko-Ishino, T, Koide, T, et al. (1998) Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis. Development 125: 15531560.Google ScholarPubMed
Obata, Y, Kono, T (2002) Maternal primary imprinting is established at a specific time for each gene throughout oocyte growth. Journal of Biological Chemistry 277: 52855289.CrossRefGoogle Scholar
O’Doherty, AM, O’Shea, LC, Fair, T (2012) Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. Biology of Reproduction 86(3): 67.Google Scholar
Odom, LN, Segars, J (2010) Imprinting disorders and assisted reproductive technology. Current Opinion in Endocrinology, Diabetes, and Obesity 17(6): 517522.CrossRefGoogle ScholarPubMed
Ohno, M, Aoki, N, Sasaki, H (2001) Allele-specific detection of nascent transcripts by fluorescence in situ hybridization reveals temporal and culture-induced changes in Igf2 imprinting during pre-implantation mouse development. Genes to Cells 6: 249259.CrossRefGoogle ScholarPubMed
Okada, Y, Scott, G, Ray, MK, Mishina, Y, Zhang, Y (2007) Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature 450(7166):119123.CrossRefGoogle ScholarPubMed
Okae, H, Chiba, H, Hiura, H, et al. (2014) Genome-wide analysis of DNA methylation dynamics during early human development. PLoS Genetics 10(12): e1004868.CrossRefGoogle ScholarPubMed
Omisanjo, OA, Biermann, K, Hartmann, S, et al. (2007) DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer. Histochemistry and Cell Biology 127: 175181.CrossRefGoogle ScholarPubMed
Ørstavik, KH, Eiklid, K, van der Hagen, CB, et al. (2003) Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmic semen injection. American Journal of Human Genetics 72: 218219.CrossRefGoogle Scholar
Ostermeier, GC, Dix, DJ, Miller, DD, Khatri, P, Krawetz, SA (2002) Spermatozoal RNA profiles of normal fertile men. Lancet 360(9335): 772777.CrossRefGoogle ScholarPubMed
Pantoja, C, de Los Rios, L, Matheu, A, Antequera, F, Serrano, M (2005) Inactivation of imprinted genes induced by cellular stress and tumorigenesis. Cancer Research 65: 2633.Google ScholarPubMed
Pastor, WA, Stroud, H, Nee, K, et al. (2014) MORC1 represses transposable elements in the mouse male germline. Nature Communications 12(5): 5795.CrossRefGoogle Scholar
Poplinski, A, Tüttelmann, F, Kanber, D, Horsthemke, B, Gromoll, J (2010) Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1. International Journal of Andrology 33(4): 642649.Google ScholarPubMed
Probst, AV, Santos, F, Reik, W, Almouzni, G, Dean, W (2007) Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote. Chromosoma 116(4): 403415.CrossRefGoogle ScholarPubMed
Qiao, J, Chen, Y, Yan, LY, et al. (2009) Changes in histone methylation during human oocyte maturation and IVF- or ICSI-derived embryo development. Fertility and Sterility 93(5): 16281636.CrossRefGoogle ScholarPubMed
Rajender, S, Avery, K, Agarwal, A (2011) Epigenetics, spermatogenesis and male infertility. Mutation Research 727: 6271.CrossRefGoogle ScholarPubMed
Reik, W, Dean, W, Walter, J (2001) Epigenetic reprogramming in mammalian development. Science 293(5532): 10891093.CrossRefGoogle ScholarPubMed
Reik, W, Maher, ER (1997) Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome. Trends in Genetics 13(8): 330334.CrossRefGoogle ScholarPubMed
Reik, W, Walter, J (2001) Genomic imprinting: parental influence on the genome. Nature Reviews (Genetics) 2: 2132.CrossRefGoogle ScholarPubMed
Renard, JP, Baldacci, P, Richouxduranthon, V, Pournin, S, Babinet, C (1994) A maternal factor affecting mouse blastocyst formation. Development 120: 797802.Google ScholarPubMed
Rivera, RM, Ross, JW (2013) Epigenetics in fertilization and preimplantation development. Prog Biophys Mol Biol 113(3): 423432.CrossRefGoogle Scholar
Rossignol, S, Steunou, V, Chalas, C, et al. (2006) The epigenetic imprinting defect of patients with Beckwith-Wiedemann syndrome born after assisted reproductive technology is not restricted to the 11p15 region. Journal of Medical Genetics 43: 902907.CrossRefGoogle Scholar
Rugg-Gunn, PJ, Ferguson-Smith, AC, Pedersen, RA (2005) Epigenetic status of human embryonic stem cells. Nature Genetics 37: 585587.CrossRefGoogle ScholarPubMed
Sagirkaya, H, Misirlioglu, M, Kaya, A, et al. (2006) Developmental and molecular correlates of bovine preimplantation embryos. Reproduction 131: 895904.CrossRefGoogle ScholarPubMed
Sagirkaya, H, Misirlioglu, M, Kaya, A, et al. (2007) Developmental potential of bovine oocytes cultured in different maturation and culture conditions. Animal Reproduction Science 101: 225240.CrossRefGoogle ScholarPubMed
Saenz-de-Juano, MD, Peñaranda, DS, Marco-Jiménez, F, Vicente, JS (2014) Does vitrification alter the methylation pattern of OCT4 promoter in rabbit late blastocyst? Cryobiology 69(1): 178180.CrossRefGoogle ScholarPubMed
Sanchez-Albisua, I, Borell-Kost, S, Mau-Holzmann, UA, Licht, P, Krägeloh-Mann, I (2007) Increased frequency of severe major anomalies in children conceived by intracytoplasmic sperm injection. Developments in Medical Child Neurology 49(2): 129134.CrossRefGoogle ScholarPubMed
Santi, D, De Vincentis, S, Magnani, E, Spaggiari, G (2017) Impairment of sperm DNA methylation in male infertility: a meta-analytic study. Andrology 5(4): 695703.CrossRefGoogle ScholarPubMed
Santos, F, Hendrich, B, Reik, W, Dean, W (2002) Dynamic reprogramming of DNA methylation in the early mouse embryo. Developmental Biology 241(1): 172182.CrossRefGoogle ScholarPubMed
Santos, F, Hyslop, L, Stojkovic, P, et al. (2010) Evaluation of epigenetic marks in human embryos derived from IVF and ICSI. Human Reproduction 25(9): 23872395.CrossRefGoogle Scholar
Sasaki, H, Ferguson-Smith, AC, Shum, AS, Barton, SC, Surani, MA (1995) Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos. Development. 121(12): 41954202.Google ScholarPubMed
Sato, A, Otsu, E, Negishi, H, Utsunomiya, T, Arima, T (2007) Aberrant DNA methylation of imprinted loci in superovulated oocytes. Human Reproduction 22: 2635.CrossRefGoogle ScholarPubMed
Schwarzer, C, Esteves, TC, Arauzo-Bravo, MJ, et al. (2012) ART culture conditions change the probability of mouse embryo gestation through defined cellular and molecular responses. Human Reproduction 27(9): 26272640.CrossRefGoogle ScholarPubMed
Shamanski, FL, Kimura, Y, Lavoir, MC, Pedersen, RA, Yanagimachi, R (1999) Status of genomic imprinting in mouse spermatids. Human Reproduction 14: 10501056.CrossRefGoogle ScholarPubMed
Sharma, U, Conine, CC, Shea, JM, et al. (2016) Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science 351(6271): 391396.CrossRefGoogle ScholarPubMed
Shea, JM, Serra, RW, Carone, BR, et al.(2015) Genetic and epigenetic variation, but not diet, shape the sperm methylome. Developmental Cell 35(6): 750758.CrossRefGoogle Scholar
Shi, W, Haaf, T (2002) Aberrant methylation patterns at the two-cell stage as an indicator of early developmental failure. Molecular Reproduction and Development 63: 329334.CrossRefGoogle ScholarPubMed
Shi, Y, Lan, F, Matson, C, et al.(2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119: 941953.CrossRefGoogle ScholarPubMed
Sikienka, K, Erek, S, Godmann, M, et al. (2015) Disruption of histone methylation in developing sperm impairs offspring health transgenerationally. Science 350(6261): aab2006.CrossRefGoogle Scholar
Skaar, DA, Li, Y, Bernal, AJ, Hoyo, C, Murphy, SK, Jirtle, RL (2012) The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility. ILAR Journal/National Research Council, Institute of Laboratory Animal Resources 53(3–4): 341358.CrossRefGoogle ScholarPubMed
Smallwood, SA, Kelsey, G (2012) Genome-wide analysis of DNA methylation in low cell numbers by reduced representation bisulfite sequencing. Methods in Molecular Biology 925: 187197.CrossRefGoogle ScholarPubMed
Smallwood, SA, Tomizawa, S, Krueger, F, et al. (2011) Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nature Genetics 43(8): 811814.CrossRefGoogle ScholarPubMed
Smith, ZD, Chan, MM, Humm, KC, et al. (2014) DNA methylation dynamics of the human preimplantation embryo. Nature 511: 611615.CrossRefGoogle ScholarPubMed
Song, S, Ghosh, J, Mainigi, M, et al. (2015) DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility. Clinical Epigenetics 7: 41.CrossRefGoogle ScholarPubMed
Soubry, A, Hoyo, C, Jirtle, RL, Murphy, SK (2014) A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. BioEssays: News and Reviews in Molecular, Cellular And Developmental Biology 36(4): 359371.CrossRefGoogle ScholarPubMed
Stouder, C, Deutsch, S, Paoloni-Giacobino, A (2009) Superovulation in mice alters the methylation pattern of imprinted genes in the sperm of the offspring. Reproductive Toxicology 28(4): 536541.CrossRefGoogle ScholarPubMed
Stuppia, L, Franzago, M, Ballerini, P, Gatta, V, Antonucci, I (2015) Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health. Clinical Epigenetics 7: 120.CrossRefGoogle ScholarPubMed
Sujit, KM,Sarkar, S, Singh, V, et al (2018) Genome-wide differential methylation analyses identifies methylation signatures of male infertility. Human Reproduction 33(12): 22562267.CrossRefGoogle ScholarPubMed
Sun, BW, Yang, AC, Feng, Y, et al. (2006) Temporal and parental-specific expression of imprinted genes in a newly derived Chinese human embryonic stem cell line and embryoid bodies. Human Molecular Genetics 15: 6575.CrossRefGoogle Scholar
Sunde, A, Brison, D, Dumoulin, J, et al. (2016) Time to take human embryo culture seriously. Human Reproduction 31(10): 21742182.CrossRefGoogle ScholarPubMed
Sutcliffe, AG, Peters, CJ, Bowdin, S, et al. (2006) Assisted reproductive therapies and imprinting disorders: a preliminary British survey. Human Reproduction 21: 10091011.CrossRefGoogle ScholarPubMed
Suzuki, J Jr, Therrien, J, Filion, F, et al. (2009) In vitro culture and somatic cell nuclear transfer affect imprinting of SNRPN gene in pre- and post-implantation stages of development in cattle. BMC Developmental Biology 9: 9.CrossRefGoogle ScholarPubMed
Svensson, J, Bjornstahl, A, Ivarsson, SA (2005) Increased risk of Silver–Russell syndrome after in vitro fertilization? Acta Paediatrica 94: 11631165.CrossRefGoogle ScholarPubMed
Tee, L, Lim, DH, Dias, RP, et al. (2013) Epimutation profiling in Beckwith-Wiedemann syndrome: relationship with assisted reproductive technology. Clinical Epigenetics 5(1): 23.CrossRefGoogle ScholarPubMed
Tenorio, J, Ramanelli, V, Martin-Trujillo, A, et al. (2016) Clinical and molecular analyses of Beckwith-Wiedemann syndrome: Comparison between spontaneous conception and assisted reproduction techniques. American Journal of Medical Genetics 170(10): 27402749.CrossRefGoogle ScholarPubMed
Torregrosa, N, Dominguez-Fandos, D, Camejo, MI, et al. (2006) Protamine 2 precursors, protamine 1/protamine 2 ratio, DNA integrity and other sperm parameters in infertile patients. Human Reproduction 21: 20842089.CrossRefGoogle ScholarPubMed
Trapphoff, T, El Hjj, N, Zechner, U, Haaf, T, Eichenlaub-Ritter, U (2010) DNA integrity, growth pattern, spindle formation, chromosomal constitution and imprinting patterns of mouse oocytes from vitrified pre-antral follicles. Human Reproduction 25(12): 30253042.CrossRefGoogle ScholarPubMed
Van der Auwera, I, D’Hooghe, T (2001) Superovulation of female mice delays embryonic and fetal development. Human Reproduction 16(6):12371243.CrossRefGoogle ScholarPubMed
Vermeiden, JP, Bernardus, RE (2013) Are imprinting disorders more prevalent after human in vitro fertilization or intracytoplasmic sperm injection? Fertility and Sterility 99(3): 642651.CrossRefGoogle ScholarPubMed
Walter, J, Paulsen, M (2003) Imprinting and disease. Seminars in Cell and Developmental Biology 14: 101110.CrossRefGoogle ScholarPubMed
Wang, Z, Xu, L, He, F (2010) Embryo vitrification affects the methylation of the H19/Igf2 differentially methylated domain and the expression of H19 and Igf2. Fertility and Sterility 93(8): 27292733.CrossRefGoogle ScholarPubMed
White, CR, Denomme, MM, Tekpetey, FR, Feyles, V, Power, SG, Mann, MR (2015) High frequency of imprinted methylation errors in human preimplantation embryos. Scientific Reports 5: 17311.CrossRefGoogle ScholarPubMed
Whitelaw, N, Bhattacharya, S, Hoad, G, Horgan, GW, Hamilton, M, Haggarty, P (2014) Epigenetic status in the offspring of spontaneous and assisted conception. Human Reproduction 29(7): 14521458.CrossRefGoogle ScholarPubMed
Yamazaki, T, Yamagata, K, Baba, T (2007) Time-lapse and retrospective analysis of DNA methylation in mouse preimplantation embryos by live cell imaging. Developmental Biology 304: 409419.CrossRefGoogle ScholarPubMed
Yan, LY, Yan, J, Qiao, J, Zhao, PL, Liu, P (2010) Effects of oocyte vitrification on histone modifications. Reproduction Fertility and Development 22(6): 920925.CrossRefGoogle ScholarPubMed
Yao, J, Geng, L, Huang, R, et al. (2017) Effect of vitrification on in vitro development and imprinted gene Grb10 in mouse embryos. Reproduction 154(3): 97105.CrossRefGoogle ScholarPubMed
Young, LE, Fernandes, K, McEvoy, TG, et al. (2001) Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nature Genetics 27: 153154.CrossRefGoogle ScholarPubMed
Young, LE, Sinclair, KD, Wilmut, I (1998) Large offspring syndrome in cattle and sheep. Reviews of Reproduction 3(3): 155163.CrossRefGoogle ScholarPubMed
Yuan, S, Schuster, A, Tang, C, et al. (2016) Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development. Development 143(4): 635647.CrossRefGoogle ScholarPubMed
Zaitseva, I, Zaitsev, S, Alenina, N, Bader, M, Krivokharchenko, A (2007) Dynamics of DNA-demethylation in early mouse and rat embryos developed in vivo and in vitro. Molecular Reproduction and Development 74(10): 12551261.CrossRefGoogle ScholarPubMed
Zandstra, H, Brentjens, LBPM, Spauwen, B, Touwslager, RNH (2018) Association of culture medium with growth, weight and cardiovascular development of IVF children at the age of 9 years. Human Reproduction 33(9): 16451656.CrossRefGoogle ScholarPubMed
Zandstra, H, Van Montfoort, AP, Dumoulin, JC (2015) Does the type of culture medium used influence birthweight of children born after IVF? Human Reproduction 30(11): 2693.CrossRefGoogle ScholarPubMed
Zhao, XM, Du, WH, Hao, HS, et al. (2012) Effect of vitrification on promoter methylation and the expression of pluripotency and differentiation genes in mouse blastocysts. Molecular Reproduction and Development 79(7): 445450.CrossRefGoogle ScholarPubMed
Zhao, XM, Ren, JJ, Du, WH, et al. (2013) Effect of vitrification on promoter CpG island methylation patterns and expression levels of DNA methyltransferase 1o, histone acetyltransferase 1, and deacetylase 1 in metaphase II mouse oocytes. Fertility and Sterility 100(1): 256261.CrossRefGoogle ScholarPubMed
Zhu, J, Li, M, Chen, L, Liu, P, Qiao, J (2014b) The protein source in embryo culture media influences birthweight: a comparative study between G1 v5 and G1-PLUS v5. Human Reproduction 29(7): 13871392.CrossRefGoogle ScholarPubMed
Zhu, J, Lin, S, Li, M, et al. (2014a) Effect of in vitro culture period on birthweight of singleton newborns. Human Reproduction 29(3): 448454.CrossRefGoogle ScholarPubMed
Zhu, P, Guo, H, Ren, Y, et al. (2018) Single-cell DNA methylome sequencing of human preimplantation embryos. Nature Genetics 50(1): 1219.CrossRefGoogle ScholarPubMed
Ziyyat, A, Lefevre, A (2001) Differential gene expression in pre-implantation embryos from mouse oocytes injected with round spermatids or spermatozoa. Human Reproduction 16: 14491456.CrossRefGoogle ScholarPubMed
Amor, DJ, Halliday, J (2008) A review of known imprinting syndromes and their association with assisted reproduction technologies. Human Reproduction 23(12): 28262834.CrossRefGoogle ScholarPubMed
ASRM Practice Committee Pages (2013) Blastocyst culture and transfer in clinical assisted reproduction: a committee opinion. Fertility and Sterility 99(3): 00150282.
Gosden, R, Trasler, J, Lucifero, D, Faddy, M (2003) Rare congenital disorders, imprinted genes, and assisted reproductive technology. Lancet 361(9373): 19751977.CrossRefGoogle ScholarPubMed
Huntriss, J, Picton, HM (2008) Epigenetic consequences of assisted reproduction and infertility on the human preimplantation embryo. Human Fertility 11(2): 8594.CrossRefGoogle ScholarPubMed
Maher, ER, Afnan, M, Barratt, CL (2003) Epigenetic risks related to assisted reproductive technologies: epigenetics, imprinting, ART and icebergs? Human Reproduction 18(12): 25082511.CrossRefGoogle ScholarPubMed
Manipalviratn, S, DeCherney, A, Segars, J (2009) Imprinting disorders and assisted reproductive technology. Fertility and Sterility 91(2): 305315.CrossRefGoogle ScholarPubMed
Roseboom, TJ (2018) Developmental plasticity and its relevance to assisted human reproduction. Human Reproduction 33(4): 546552.CrossRefGoogle ScholarPubMed
Abeyta, MJ, Clark, AT, Rodriguez, RT, et al. (2004) Unique gene expression signatures of independently-derived human embryonic stem cell lines. Human Molecular Genetics 13: 601608.CrossRefGoogle ScholarPubMed
Adewumi, O, Aflatoonian, B, Ahrlund-Richter, L, et al. (2007) Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nature Biotechnology 25: 803816.Google ScholarPubMed
Albert, M, Peters, AH (2009) Genetic and epigenetic control of early mouse development. Current Opinion in Genetics and Development 19(2): 113121.CrossRefGoogle ScholarPubMed
Allegrucci, C, Wu, YZ, Thurston, A, et al. (2007) Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome. Human Molecular Genetics 16: 12531268.CrossRefGoogle ScholarPubMed
Anckaert, E, Adriaenssens, T, Romero, S, Dremier, S, Smitz, J (2009a) Unaltered imprinting establishment of key imprinted genes in mouse oocytes after in vitro follicle culture under variable follicle-stimulating hormone exposure. International Journal of Developmental Biology 53(4): 541548.CrossRefGoogle ScholarPubMed
Anckaert, E, Adriaenssens, T, Romero, S, Smitz, J (2009b) Ammonium accumulation and use of mineral oil overlay do not alter imprinting establishment at three key imprinted genes in mouse oocytes grown and matured in a long-term follicle culture. Biology of Reproduction 81(4): 666673.CrossRefGoogle ScholarPubMed
Anteby, I, Cohen, E, Anteby, E, BenEzra, D (2001) Ocular manifestations in children born after in vitro fertilization. Archives of Ophthalmology 119(10): 15251529.CrossRefGoogle ScholarPubMed
Aoki, VW, Emery, BR, Liu, L, Carrell, DT (2006a) Protamine levels vary between individual sperm cells of infertile human males and correlate with viability and DNA integrity. Journal of Andrology 27: 890898.CrossRefGoogle ScholarPubMed
Aoki, VW, Liu, L, Jones, KP, et al. (2006b) Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability. Fertility and Sterility 86: 14081415.CrossRefGoogle ScholarPubMed
Aoki, VW, Moskovtsev, SI, Willis, J, et al. (2005) DNA integrity is compromised in protamine-deficient human sperm. Journal of Andrology 26: 741748.CrossRefGoogle ScholarPubMed
Apostolidou, S, Abu-Amero, S, O’Donoghue, K, et al. (2007) Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight. Journal of Molecular Medicine 85: 379387.CrossRefGoogle ScholarPubMed
Aravin, AA, Hannon, GJ (2008) Small RNA silencing pathways in germ and stem cells. Cold Spring Harbor Symposia on Quantitative Biology 73: 283290.CrossRefGoogle ScholarPubMed
Aston, KI, Carrell, DT (2014) Prospects for clinically relevant epigenetic tests in the andrology laboratory. Asian Journal of Andrology 16(5): 782.CrossRefGoogle ScholarPubMed
Batcheller, A, Cardozo, E, Maguire, M, DeCherney, AH, Segars, JH (2011) Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies? Fertility and Sterility 96(6):13061311.CrossRefGoogle ScholarPubMed
Beaujean, N, Hartshorne, G, Cavilla, J, et al. (2004) Non-conservation of mammalian preimplantation methylation dynamics. Current Biology 14(7): R266–267.CrossRefGoogle ScholarPubMed
Bell, AC, Felsenfeld, G (2000) Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405(6785): 482485.CrossRefGoogle ScholarPubMed
Benchaib, M, Braun, V, Ressnikof, D, et al. (2005) Influence of global sperm DNA methylation on IVF results. Human Reproduction 20: 768773.CrossRefGoogle ScholarPubMed
Bliek, J, Terhal, P, van den Bogaard, MJ, et al. (2006) Hypomethylation of the H19 gene causes not only Silver–Russell syndrome (SRS) but also isolated asymmetry or an SRS-like phenotype. American Journal of Human Genetics 78: 604614.CrossRefGoogle Scholar
Blondin, P, Farin, PW, Crosier, AE, Alexander, JE, Farin, CE (2000) In vitro production of embryos alters levels of insulin-like growth factor-II messenger ribonucleic acid in bovine fetuses 63 days after transfer. Biology and Reproduction 62(2): 384389.CrossRefGoogle ScholarPubMed
Boissonnas, CC, Abdalaoui, HE, Haelewyn, V, et al. (2010) Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men. European Journal of Human Genetics 18(1): 7380.CrossRefGoogle ScholarPubMed
Boissonnas, CC, Jouannet, P, Jammes, H (2013). Epigenetic disorders and male subfertility. Fertility and Sterility 99(3): 624631.CrossRefGoogle ScholarPubMed
Boonen, SE, Porksen, S, Mackay, DJ, et al. (2008) Clinical characterisation of the multiple maternal hypomethylation syndrome in siblings. European Journal of Human Genetics 16: 453461.CrossRefGoogle ScholarPubMed
Borghol, N, Blachère, T, Lefèvre, A (2008) Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatid injection into mouse oocytes. Genomics 91(5): 415422.CrossRefGoogle ScholarPubMed
Borghol, N, Lornage, J, Blachere, T, Sophie Garret, A, Lefevre, A (2006) Epigenetic status of the H19 locus in human oocytes following in vitro maturation. Genomics 87: 417426.CrossRefGoogle ScholarPubMed
Bourc’his, D, Xu, GL, Lin, CS, Bollman, B, Bestor, TH (2001) Dnmt3L and the establishment of maternal genomic imprints. Science 294(5551): 25362539.CrossRefGoogle ScholarPubMed
Bourque, DK, Avila, L, Peñaherrera, M, von Dadelszen, P, Robinson, WP (2010) Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia. Placenta 31(3): 197202.CrossRefGoogle Scholar
Camprubi, C, Iglesias-Platas, I, Martin-Trujillo, A, et al. (2013) Stability of genomic imprinting and gestational-age dynamic methylation in complicated pregnancies conceived following assisted reproductive technologies. Biology of Reproduction 89(3): 50.CrossRefGoogle ScholarPubMed
Carlone, DL, Lee, JH, Young, SR, et al. (2005) Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein. Molecular and Cellular Biology 25(12): 48814891.CrossRefGoogle ScholarPubMed
Carlone, DL, Skalnik, DG (2001) CpG binding protein is crucial for early embryonic development. Molecular and Cellular Biology 21(22): 76017606.CrossRefGoogle ScholarPubMed
Carrasco, B, Boada, M, Rodriguez, I, Coroleu, B, Barri, PN, Veiga, A (2013) Does culture medium influence offspring birth weight? Fertility and Sterility 100(5): 12831288.CrossRefGoogle ScholarPubMed
Carrell, DT (2012) Epigenetics of the male gamete. Fertility and Sterility 97(2): 267274.CrossRefGoogle ScholarPubMed
Carrell, DT, Emery, BR, Hammoud, S (2007) Altered protamine expression and diminished spermatogenesis: what is the link? Human Reproduction Update 13: 313327.CrossRefGoogle ScholarPubMed
Cetin, I, Cozzi, V, Antonazzo, P (2003) Fetal development after assisted reproduction – a review. Placenta 24(Suppl. B): S104–113.CrossRefGoogle ScholarPubMed
Chang, AS, Moley, KH, Wangler, M, Feinberg, AP, Debaun, MR (2005) Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertility and Sterility 83: 349354.CrossRefGoogle ScholarPubMed
Charalambous, M, Ferron, SR, da Rocha, ST, et al. (2012) Imprinted gene dosage is critical for the transition to independent life. Cell Metabolism 15(2): 209221.CrossRefGoogle ScholarPubMed
Chatterjee, A, Saha, D, Niemann, H, Gryshkov, O, Gismacher, B, Hofmann, N (2017) Effects of cryopreservation on the epigenetic profile of cells. Cryobiology 74: 17.CrossRefGoogle Scholar
Chen, Z, Hagen, DE, Elsik, CG, et al. (2015) Characterization of global loss of imprinting in fetal overgrowth syndrome induced by assisted reproduction. Proceedings of the National Academy of Sciences of the USA 112(15): 46184623.CrossRefGoogle ScholarPubMed
Chen, Q, Yan, M, Cao, Z, et al. (2016) Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 351(6271): 397400.CrossRefGoogle ScholarPubMed
Chen, H, Zhang, L, Deng, T, et al. (2016) Effects of oocyte vitrification on epigenetic status in early bovine embryos. Theriogenology 86(3): 868878.CrossRefGoogle ScholarPubMed
Cheng, KR, Fu, XW, Zhang, RN, Jia, GX, Hou, YP, Zhu, SE (2014) Effect of oocyte vitrification on deoxyribonucleic acid methylation of H19, Peg3, and Snrpn differentially methylated regions in mouse blastocysts. Fertility and Sterility 102(4): 11831190.CrossRefGoogle ScholarPubMed
Chopra, M, Amor, DJ, Sutton, L, Algar, E, Mowat, D (2010) Russell-Silver syndrome due to paternal H19/IGF2 hypomethylation in a patient conceived using intracytoplasmic sperm injection. Reproductive Biomedicine Online 20(6): 843847.CrossRefGoogle Scholar
Chotalia, M, Smallwood, SA, Ruf, N, et al. (2009) Transcription is required for establishment of germline methylation marks at imprinted genes. Genes and Development 23(1): 105117.CrossRefGoogle ScholarPubMed
Choufani, S, Turinsky, AL, Melamed, N, et al. (2018) Impact of assisted reproduction, infertility, sex, and paternal factors on the placental DNA methylome. Human Molecular Genetics 28(3): 372385.CrossRefGoogle Scholar
Ciccone, DN, Su, H, Hevi, S, et al. (2009) KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature 461(7262): 415418.CrossRefGoogle ScholarPubMed
Coan, PM, Burton, GJ, Ferguson-Smith, AC (2005) Imprinted genes in the placenta; a review. Placenta 26: S10–20.CrossRefGoogle ScholarPubMed
Constância, M, Pickard, B, Kelsey, G, Reik, W (1998) Imprinting mechanisms. Genome Research 8(9): 881900.CrossRefGoogle ScholarPubMed
Corry, GN, Tanasijevic, B, Barry, ER, Krueger, W, Rasmussen, TP (2009) Epigenetic regulatory mechanisms during preimplantation development. Birth Defects Research Part C Embryo Today 87(4): 297313.CrossRefGoogle ScholarPubMed
Cox, GF, Burger, J, Lip, V, et al. (2002) Intracytoplasmic sperm injection may increase the risk of imprinting defects. American Journal of Human Genetics 1(1): 162164.CrossRefGoogle Scholar
Dahl, JA, Reiner, AH, Klungland, A, Wakayama, T, Collas, P (2010) Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos. PLoS One 5(2): e9150.CrossRefGoogle ScholarPubMed
DeBaun, MR, Niemitz, EL, Feinberg, AP (2003) Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. American Journal of Human Genetics 72: 156160.CrossRefGoogle ScholarPubMed
De Munck, N, Petrussa, L, Verheyen, G, et al. (2015) Chromosomal meiotic segregation, embryonic developmental kinetics and DNA (hydroxy)methylation analysis consolidate the safety of human oocyte vitrification. Molecular Human Reproduction 21(6): 535544.CrossRefGoogle ScholarPubMed
Denomme, MM, Mann, MR (2012) Genomic imprints as a model for the analysis of epigenetic stability during assisted reproductive technologies. Reproduction 144(4): 393409.CrossRefGoogle ScholarPubMed
Denomme, MM, McCallie, BR, Parks, JC, Schoolcraft, WB, Katz-Jaffe, MG (2017) Alterations in the sperm histone retained epigenome are associated with unexplained male factor infertility and poor blastocyst development in donor oocyte IVF cycles. Human Reproduction 32(12): 24432455.CrossRefGoogle ScholarPubMed
Denomme, MM, Zhang, L, Mann, MR (2011) Embryonic imprinting perturbations do not originate from superovulation-induced defects in DNA methylation acquisition. Fertility and Sterility 96(3): 734–738.e2.CrossRefGoogle Scholar
de Castro Barbosa, T, Ingerslev, LR, Alm, PS, et al. (2016) High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Molecular Metabolism 5(3): 184197.CrossRefGoogle ScholarPubMed
De Vos, A, Janssens, R, Van de Velde, H, et al. (2015) The type of culture medium and the duration of in vitro culture do not influence birthweight of ART singletons. Human Reproduction 30(1): 2027.CrossRefGoogle Scholar
Derakhshan-Horeh, M, Abolhassani, F, Jafarpour, F, et al. (2016) Vitrification at Day 3 stage appears not to affect the methylation status of H19/IGF2 differentially methylated region of in vitro produced human blastocysts. Cryobiology 73(2): 168174.CrossRefGoogle Scholar
Doherty, AS, Mann, MR, Tremblay, KD, Bartolomei, MS, Schultz, RM (2000) Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biology of Reproduction 62(6): 15261535.CrossRefGoogle ScholarPubMed
Doornbos, ME, Maas, SM, McDonnell, J, Vermeiden, JP, Hennekam, RC (2007) Infertility, assisted reproduction technologies and imprinting disturbances: a Dutch study. Human Reproduction 22: 24762480.CrossRefGoogle ScholarPubMed
Dumoulin, JC, Land, JA, Van Montfoort, AP, et al. (2010) Effect of in vitro culture of human embryos on birthweight of newborns. Human Reproduction 25(3): 605612.CrossRefGoogle ScholarPubMed
Eggermann, T, Perez de Nanclares, G, Maher, ER, et al. (2015) Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci. Clinical Epigenetics 7: 123.CrossRefGoogle ScholarPubMed
Eskld, A, Monkerud, L, Tanbo, T (2013) Birthweight and placental weight; do changes in culture media used for IVF matter? Comparisons with spontaneous pregnancies in the corresponding time periods. Human Reproduction 28(12): 32073214.CrossRefGoogle Scholar
Fauque, P (2013) Superovulation: ovulation induction and epigenetic anomalies. Fertility and Sterility 99(3): 616623.CrossRefGoogle Scholar
Fauque, P, Jouannet, P, Lesaffre, C, et al. (2007) Assisted reproductive technology affects developmental kinetics, H19 imprinting control region methylation and H19 gene expression in individual mouse embryos. BMC Developmental Biology 7: 116.CrossRefGoogle ScholarPubMed
Fauque, P, Mondon, F, Letourneur, F, et al. (2010b) In vitro fertilization and embryo culture strongly impact the placental transcriptome in the mouse model. PLoS One 5(2): e9218.CrossRefGoogle ScholarPubMed
Fauque, P, Ripoche, MA, Tost, J, et al. (2010a) Modulation of imprinted gene network in placenta results in normal development of in vitro manipulated mouse embryos. Human Molecular Genetics 19(9): 17791790CrossRefGoogle ScholarPubMed
Fenic, I, Hossain, HM, Sonnack, V, et al. (2008) In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. Journal of Andrology 29: 172185.CrossRefGoogle ScholarPubMed
Fenic, I, Sonnack, V, Failing, K, Bergmann, M, Steger, K (2004) In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis Journal of Andrology 25: 811818.CrossRefGoogle ScholarPubMed
Fernandez-Gonzalez, R, Moreira, P, Bilbao, A, et al. (2004) Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior. Proceedings of the National Academy of Sciences of the USA 101: 58805885.CrossRefGoogle Scholar
Fortier, AL, Lopes, FL, Darricarrère, N, Martel, J, Trasler, JM (2008) Superovulation alters the expression of imprinted genes in the midgestation mouse placenta. Human Molecular Genetics 17(11): 16531665.CrossRefGoogle ScholarPubMed
Fortier, AL, McGraw, S, Lopes, FL, et al. (2014) Modulation of imprinted gene expression following superovulation. Molecular and Cellular Endocrinology 388(1–2): 5157.CrossRefGoogle ScholarPubMed
Frost, RJ, Hamra, FK, Richardson, JA, Qi, X, BAssel-Duby, R, Olson, EN (2010) MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proceedings of the National Academy of Sciences of the USA 107: 1184711852.CrossRefGoogle ScholarPubMed
Gad, A, Schellander, K, Hoelker, M, Tesfaye, D (2012) Transcriptome profile of early mammalian embryos in response to culture environment. Animal Reproduction Science 134(1–2): 7683.CrossRefGoogle ScholarPubMed
Galli-Tsinopoulou, A, Emmanouilidou, E, Karagianni, P, et al. (2008) A female infant with Silver Russell Syndrome, mesocardia and enlargement of the clitoris. Hormones (Athens) 7: 7781.CrossRefGoogle ScholarPubMed
Gardner, DK, Kelly, RL (2017) Impact of the IVF laboratory environment on human preimplantation embryo phenotype. Journal of Developmental Origins of Health and Disease 8(4): 418435.CrossRefGoogle ScholarPubMed
Ge, ZJ, Liang, QX, Hou, Y, et al. (2014) Maternal obesity and diabetes may cause DNA methylation alteration in the spermatozoa of offspring in mice. Reproductive Biology and Endocrinology 12: 29.CrossRefGoogle ScholarPubMed
Geuns, E, De Rycke, M, Van Steirteghem, A, Leibaers, I (2003) Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos. Human Molecular Genetics 12(22): 28732879.CrossRefGoogle ScholarPubMed
Ghosh, J, Coutifaris, C, Sapienza, C, Mainigi, M (2017) Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies. Clinical Epigenetics 9: 14.CrossRefGoogle ScholarPubMed
Gicquel, C, Gaston, V, Mandelbaum, J, et al. (2003) In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. American Journal of Human Genetics 72: 1338.CrossRefGoogle ScholarPubMed
Ginsburg, M, Snow, MH, McLaren, A (1990) Primordial germ cells in the mouse embryo during gastrulation. Development 110: 521528.Google ScholarPubMed
Gomes, MV, Huber, J, Ferriani, RA, Amaral Neto, AM, Ramos, ES (2009) Abnormal methylation at the KvDMR1 imprinting control region in clinically normal children conceived by assisted reproductive technologies. Molecular and Human Reproduction 15(8): 471477.CrossRefGoogle ScholarPubMed
Gross, N, Kroop, J, Khatib, H (2017) MicroRNA signaling in embryo development. Biology (Basel) 6(3): pii:E34.Google ScholarPubMed
Guo, H, Zhu, P, Yan, L, et al. (2014) The DNA methylation landscape of human early embryos. Nature 511: 606610.CrossRefGoogle ScholarPubMed
Halliday, J, Oke, K, Breheny, S, Algar, EJ Amor, D (2004) Beckwith-Wiedemann syndrome and IVF: a case-control study. American Journal of Human Genetics 75: 526528.CrossRefGoogle ScholarPubMed
Hammoud, SS, Purwar, J, Pflueger, C, Cairns, BR, Carrell, DT (2010) Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility. Fertility and Sterility 94(5): 17281733.CrossRefGoogle ScholarPubMed
Hammoud, SS, Nix, DA, Hammoud, AO, Gibson, M, Cairns, BR, Carrell, DT (2011) Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men. Human Reproduction 26: 25582569.CrossRefGoogle ScholarPubMed
Hammoud, SS, Nix, DA, Zhang, H, Purwar, K, Carrell, DT, Cairns, BR (2009) Distinctive chromatin in human sperm packages genes for embryo development. Nature 460: 473478.CrossRefGoogle ScholarPubMed
Hata, K, Okano, M, Lei, H, Li, E (2002) Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129(8): 19831993.Google ScholarPubMed
Hayashi, S, Yang, J, Christenson, L, Yanagimachi, R, Hecht, NB (2003) Mouse preimplantation embryos developed from oocytes injected with round spermatids or spermatozoa have similar but distinct patterns of early messenger RNA expression. Biology of Reproduction 69: 11701176.CrossRefGoogle ScholarPubMed
Hiendleder, S, Mund, C, Reichenbach, HD, et al. (2004) Tissue-specific elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques. Biology of Reproduction 71(1): 217223.CrossRefGoogle ScholarPubMed
Hill, PW, Amouroux, R, Hajkova, P (2014) DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: an emerging complex story. Genomics 104(5): 324333.CrossRefGoogle ScholarPubMed
Hirasawa, R, Chiba, H, Kaneda, M, et al. (2008) Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes and Development 22(12): 16071616.CrossRefGoogle ScholarPubMed
Hiura, H, Obata, Y, Komiyama, J, Shirai, M, Kono, T (2006) Oocyte growth-dependent progression of maternal imprinting in mice. Genes to Cells 11(4): 353361.CrossRefGoogle ScholarPubMed
Hiura, H, Okae, H, Chiba, H, et al. (2014) Imprinting methylation errors in ART. Reproductive Medicine and Biology 13(4): 193202.CrossRefGoogle ScholarPubMed
Hiura, H, Okae, H, Miyauchi, N, et al. (2012) Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. Human Reproduction 27(8): 25412548.CrossRefGoogle ScholarPubMed
Holm, TM, Jackson-Grusby, L, Brambrink, T, et al. (2005) Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell 8: 275285.CrossRefGoogle ScholarPubMed
Hotaling, J, Carrell, DT (2014) Clinical genetic testing for male factor infertility: current applications and future directions. Andrology 2(3): 339350.CrossRefGoogle ScholarPubMed
Houshdaran, S, Cortessis, VK, Siegmund, K, et al. (2007) Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One 2(12): e1289.CrossRefGoogle ScholarPubMed
Huffman, SR, Pak, Y, Rivera, RM (2015) Superovulation induces alterations in the epigenome of zygotes, and results in differences in gene expression at the blastocyst stage in mice. Molecular Reproduction and Development 82(3): 207217.CrossRefGoogle ScholarPubMed
Huntriss, J (2011) Epigenetics and assisted reproduction. In: Elder, K, Dale, B (eds.) In-Vitro Fertilization, 3rd edn. Cambridge University Press, Cambridge, UK, pp. 252267.Google Scholar
Huntriss, J, Balen, AH, Sinclair, KD, Brison, DR, Picton, HM; Royal College of Obstetricians Gynaecologists (2018) Epigenetics and Reproductive Medicine: Scientific Impact Paper No. 57. BJOG 125(13): e43e54.CrossRefGoogle ScholarPubMed
Huntriss, JD, Hemmings, KE, Hinkins, M, et al. (2013) Variable imprinting of the MEST gene in human preimplantation embryos. European Journal of Human Genetics 21(1): 4047.CrossRefGoogle ScholarPubMed
Huntriss, J, Picton, HM (2008) Epigenetic consequences of assisted reproduction and infertility on the human preimplantation embryo. Human Fertility (Cambridge) 11(2): 8594.CrossRefGoogle ScholarPubMed
Ibala-Romdhane, S, Al-Khtib, M, Khoueiry, R, Blachére, T, Guerin, JF, Lefévre, A (2011) Analysis of H19 methylation in control and abnormal human embryos, sperm and oocytes. European Journal of Human Genetics 19(11): 11381143.CrossRefGoogle ScholarPubMed
Imamura, T, Kerjean, A, Heams, T, et al. (2005) Dynamic CpG and non-CpG methylation of the Peg1/Mest gene in the mouse oocyte and preimplantation embryo. Journal of Biological Chemistry 280: 2017120175.CrossRefGoogle ScholarPubMed
Isles, AR, Holland, AJ (2005) Imprinted genes and mother-offspring interactions. Early Human Development 81: 7377.CrossRefGoogle ScholarPubMed
Jenkins, TG, Aston, KI, Pflueger, C, Cairns, BR, Carrell, DT (2014) Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genetics 10(7): e1004458.CrossRefGoogle ScholarPubMed
Jenkins, TG, James, ER, Alonso, DF, et al. (2017) Cigarette smoking significantly alters sperm DNA methylation patterns. Andrology 5(6): 10891099.CrossRefGoogle ScholarPubMed
Johnson, JP, Schoof, J, Beischel, L, et al. (2018) Detection of a case of Angelman syndrome caused by an imprinting error in 949 pregnancies analyzed for AS following IVF. Journal of Assisted Reproduction and Genetics 35(6): 981984.CrossRefGoogle ScholarPubMed
Kagami, M, Nagai, T, Fukami, M, Yamazawa, K, Ogata, T (2007) Silver-Russell syndrome in a girl born after in vitro fertilization: partial hypermethylation at the differentially methylated region of PEG1/MEST. Journal of Assisted Reproduction and Genetics 24: 131136.CrossRefGoogle Scholar
Källén, B, Finnström, O, Lindam, A, et al. (2010) Congenital malformations in infants born after in vitro fertilization in Sweden. Birth Defects Research A: Clinical and Molecular Teratology 88(3): 137143.Google ScholarPubMed
Källén, B, Finnström, O, Nygren, KG, Olausson, PO (2005) In vitro fertilization (IVF) in Sweden: infant outcome after different IVF fertilization methods. Fertility and Sterility 84: 611617.CrossRefGoogle ScholarPubMed
Kanber, D, Berulava, T, Ammerpohl, O, et al. (2009a) The human retinoblastoma gene is imprinted. PLoS Genetics 5(12): e1000790.CrossRefGoogle ScholarPubMed
Kanber, D, Buiting, K, Zeschnigk, M, Ludwig, M, Horsthemke, B (2009b) Low frequency of imprinting defects in ICSI children born small for gestational age. European Journal of Human Genetics 17(1): 2229.CrossRefGoogle ScholarPubMed
Kerjean, A, Couvert, P, Heams, T, et al. (2003) In vitro follicular growth affects oocyte imprinting establishment in mice. European Journal of Human Genetics 11: 493496.CrossRefGoogle ScholarPubMed
Khosla, S, Dean, W, Brown, D, Reik, W, Feil, R (2001) Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biology of Reproduction 64: 918926.CrossRefGoogle ScholarPubMed
Khoueiry, R, Ibala-Rhomdane, S, Al-Khtib, M, et al. (2012) Abnormal methylation of KCNQ1OT1 and differential methylation of H19 imprinting control regions in human ICSI embryos. Zygote 21: 110.Google ScholarPubMed
Khoueiry, R, Ibala-Rhomdane, S, Méry, L, et al. (2008) Dynamic CpG methylation of the KCNQ1OT1 gene during maturation of human oocytes. Journal of Medical Genetics 45(9): 583588.CrossRefGoogle ScholarPubMed
Kim, KP, Thurston, A, Mummery, C, et al. (2007) Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines. Genome Research 17: 17311742.CrossRefGoogle ScholarPubMed
Kimber, SJ, Sneddon, SF, Bloor, DJ, et al. (2008) Expression of genes involved in early cell fate decisions in human embryos and their regulation by growth factors. Reproduction 135(5): 635647.CrossRefGoogle ScholarPubMed
Kishigami, S, Van Thuan, N, Hikichi, T, et al. (2006) Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. Developmental Biology 289: 195205.CrossRefGoogle ScholarPubMed
Klaver, R, Gromoll, J (2014) Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives. Asian Journal of Andrology 16(5): 669674.Google Scholar
Kleijkers, SH, Eijssen, LM, Coonen, E, et al.(2015a) Differences in gene expression profiles between human preimplantation embryos cultured in two different IVF culture media. Human Reproduction 30(10): 23032311.CrossRefGoogle ScholarPubMed
Kleijkers, SH, van Montfoort, AP, Smits, LJ, et al. (2015b) Age of G-1 PLUS v5 embryo culture medium is inversely associated with birthweight of the newborn. Human Reproduction 30(6): 13521357.CrossRefGoogle ScholarPubMed
Kobayashi, H, Hiura, H, John, RM, et al. (2009) DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. European Journal of Human Genetics 17(12): 15821591.CrossRefGoogle ScholarPubMed
Kobayashi, H, Sato, A, Otsu, E, et al. (2007) Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients. Human Molecular Genetics 16: 25422551.CrossRefGoogle ScholarPubMed
Kono, T (2009) Genetic modification for bimaternal embryo development. Reproduction and Fertility Development 21(1): 3136.CrossRefGoogle ScholarPubMed
Kurihara, Y, Kawamura, Y, Uchijima, Y, et al. (2008) Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1. Developmental Biology 313(1): 335346.CrossRefGoogle ScholarPubMed
Lane, M, Gardner, DK (1994) Increase in postimplantation development of cultured mouse embryos by amino acids and induction of fetal retardation and exencephaly by ammonium ions. Journal of Reproduction & Fertility 102(2): 305312.CrossRefGoogle ScholarPubMed
Lane, M, Gardner, DK (2003) Ammonium induces aberrant blastocyst differentiation, metabolism, pH regulation, gene expression and subsequently alters fetal development in the mouse. Biology of Reproduction 69: 11091117.CrossRefGoogle ScholarPubMed
Lazaraviciute, G, Kauser, M, Bhattacharya, S, Haggarty, P (2014) A systematic review and meta-analysis of DNA methylation levels and imprinting disorders in children conceived by IVF/ICSI compared with children conceived spontaneously. Human Reproduction Update 20(6): 840852.CrossRefGoogle ScholarPubMed
Lee, I, Finger, PT, Grifo, JA, et al. (2004) Retinoblastoma in a child conceived by in vitro fertilisation. British Journal of Ophthalmology 88(8): 10981099.CrossRefGoogle Scholar
Lee, MG, Wynder, C, Cooch, N, Shiekhattar, R (2005) An essential role for CoREST in nucleosomal histone-3-lysine-4 demethylation. Nature 437: 432435.CrossRefGoogle ScholarPubMed
Lee, YS, Latham, KE, Vandevoort, CA (2008) Effects of in vitro maturation on gene expression in rhesus monkey oocytes. Physiological Genomics 35(2): 145158.CrossRefGoogle ScholarPubMed
Lees-Murdock, DJ, Lau, HT, Castrillon, DH, De Felici, M, Walsh, CP (2008) DNA methyltransferase loading, but not de novo methylation, is an oocyte-autonomous process stimulated by SCF signalling. Developmental Biology 321(1): 238250.CrossRefGoogle Scholar
Lees-Murdock, DJ, Walsh, CP (2008) DNA methylation reprogramming in the germ line. Advances in Experimental Medicine and Biology 626: 115.CrossRefGoogle ScholarPubMed
Li, G, Yu, Y, Fan, Y, et al. (2017) Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology. Journal of Genetics and Genomics 44(10): 475481.CrossRefGoogle ScholarPubMed
Li, T, Vu, TH, Ulaner, GA, et al. (2005) IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch. Molecular Human Reproduction 11: 631640.CrossRefGoogle ScholarPubMed
Li, X, Ito, M, Zhou, F, et al. (2008) A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Developmental Cell 15(4): 547557.CrossRefGoogle ScholarPubMed
Liang, XW, Zhu, JQ, Miao, YL, et al. (2008) Loss of methylation imprint of Snrpn in postovulatory aging mouse oocyte. Biochemical and Biophysical Research Communications 371(1): 1621.CrossRefGoogle ScholarPubMed
Liang, Y, Fu, XW, Li, JJ, Yuan, DS, Zhu, SE (2014) DNA methylation pattern in mouse oocytes and their in vitro fertilized early embryos: effect of oocyte vitrification. Zygote 22(2): 138145.CrossRefGoogle ScholarPubMed
Lim, D, Bowdin, SC, Tee, L, et al. (2009) Clinical and molecular genetic features of Beckwith-Wiedemann syndrome associated with assisted reproductive technologies. Human Reproduction 24(3): 741747.CrossRefGoogle ScholarPubMed
Lin, S, Li, M, Lian, Y, Chen, L, Liu, P (2013) No effect of embryo culture media on birthweight and length of newborns. Human Reproduction 28(7): 17621767.CrossRefGoogle ScholarPubMed
Lucifero, D, La Salle, S, Bourc’his, D, et al. (2007) Coordinate regulation of DNA methyltransferase expression during oogenesis. BMC Developmental Biology 7: 36.CrossRef