Book contents
- In-Vitro Fertilization
- In-Vitro Fertilization
- Copyright page
- Contents
- Preface
- Acknowledgments
- Chapter 1 Review of Cell and Molecular Biology
- Chapter 2 Endocrine Control of Reproduction
- Chapter 3 Gametes and Gametogenesis
- Chapter 4 Gamete Interaction
- Chapter 5 First Stages of Development
- Chapter 6 Implantation and Early Stages of Fetal Development
- Chapter 7 Stem Cell Biology
- Chapter 8 The Clinical In-Vitro Fertilization Laboratory
- Chapter 9 Quality Management in the IVF Laboratory
- Chapter 10 Sperm and ART
- Chapter 11 Oocyte Retrieval and Embryo Culture
- Chapter 12 Cryopreservation of Gametes and Embryos
- Chapter 13 Micromanipulation Techniques
- Chapter 14 Preimplantation Genetic Diagnosis
- Chapter 15 Epigenetics and Human Assisted Reproduction
- Index
- References
Chapter 14 - Preimplantation Genetic Diagnosis
Published online by Cambridge University Press: 24 December 2019
- In-Vitro Fertilization
- In-Vitro Fertilization
- Copyright page
- Contents
- Preface
- Acknowledgments
- Chapter 1 Review of Cell and Molecular Biology
- Chapter 2 Endocrine Control of Reproduction
- Chapter 3 Gametes and Gametogenesis
- Chapter 4 Gamete Interaction
- Chapter 5 First Stages of Development
- Chapter 6 Implantation and Early Stages of Fetal Development
- Chapter 7 Stem Cell Biology
- Chapter 8 The Clinical In-Vitro Fertilization Laboratory
- Chapter 9 Quality Management in the IVF Laboratory
- Chapter 10 Sperm and ART
- Chapter 11 Oocyte Retrieval and Embryo Culture
- Chapter 12 Cryopreservation of Gametes and Embryos
- Chapter 13 Micromanipulation Techniques
- Chapter 14 Preimplantation Genetic Diagnosis
- Chapter 15 Epigenetics and Human Assisted Reproduction
- Index
- References
Summary
Preimplantation genetic diagnosis (PGD) was developed in the late 1980s to help couples who are at risk of transmitting an inherited disease to their offspring, as an alternative to prenatal diagnosis during pregnancy. Prenatal diagnosis has the disadvantage that if the diagnosis shows the fetus to be affected, the couple must decide whether they wish to terminate the pregnancy or continue with the knowledge that their child is going to be affected by the genetic disease. PGD offers some of these couples an alternative, as the diagnosis is performed on the preimplantation embryo, and only embryos assessed as being unaffected by the genetic disease are transferred to the patient. The pregnancy is therefore initiated with the knowledge that the fetus is free from the disease, at that moment in time.
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- Information
- In-Vitro Fertilization , pp. 311 - 330Publisher: Cambridge University PressPrint publication year: 2020