Delivering healthcare is both a deeply gratifying and a demanding occupation. Physicians and healthcare professionals (clinicians) are trained to have a knowledge base and skill set that are firmly rooted in evidence and hard science. However, they must also be facile with the soft skills, exhibiting flexibility and creativity when addressing unknown or unexpected challenges. In today’s highly matrixed healthcare environment it often is not enough for a clinician to be a skilled practitioner with a compassionate bedside manner; they may have to serve as scholar, expert, administrator, and leader of teams, managing staff without the benefit of clear lines of accountability. When all goes well, the clinician is able to sustain high levels of productivity over a long career, taking good care of patients and supporting health system transformation while simultaneously being engaged members of their family and fulfilling roles within their communities.