Skip to main content Accessibility help
Hostname: page-component-99c86f546-7mfl8 Total loading time: 2.183 Render date: 2021-12-07T22:24:31.348Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }


Published online by Cambridge University Press:  01 June 2018

Philip N. Patsalos
UCL Institute for Neurology
Erik K. St Louis
Mayo Clinic
Get access


Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Publisher: Cambridge University Press
Print publication year: 2018

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)


Biton, V, Berkovic, SF, Abou-Khalil, B, Sperling, MR, Johnson, ME, Lu, S. Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double blind, placebo-controlled trial. Epilepsia 2014; 55: 5766.CrossRefGoogle ScholarPubMed
Coppola, G, Iapadre, G, Operto, FF, Verrotti, A. New developments in the management of partial-onset epilepsy: role of brivaracetam. Drug Design Development and Therapy 2017; 11: 643657.CrossRefGoogle ScholarPubMed
Klein, P, Biton, V, Dilley, D, Barnes, M, Schiemann, J, Lu, S. Safety and tolerability of adjunctive brivaracetam as intravenous infusion or bolus in patients with epilepsy. Epilepsia 2016; 57: 11301138.CrossRefGoogle ScholarPubMed
Klein, P, Schiemann, J, Sperling, MR, Whitesides, J, Liang, W, Stalvey, T, Brandt, C, Kwan, P. A randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizures. Epilepsia 2015; 56: 18901898.CrossRefGoogle ScholarPubMed
Klitgaard, H, Matagne, A, Nicolas, JM, Gillard, M, Lamberty, Y, De Ryck, M, Kaminski, RM, Leclercq, K, Niespodziany, I, Wilff, C, Wood, M, Hannestad, J, Kervyn, S, Kenda, B. Brivaracetam: rationale for dicovery and preclinical profile of a sellective SV2A ligand for epilepsy treatment. Epilepsia 2016; 57: 538548.CrossRefGoogle Scholar
Kruithof, AC, Watanabe, S, Peeters, PA, de Kam, ML, Zuiker, RG, Stevens, J, van Gerven, JM, Stockis, A. Pharmacological interactions between brivaracetam and ethanol in healthy males. Journal of Psychopharmacology 2017; 31: 915926.CrossRefGoogle ScholarPubMed
Kwan, P, Trinka, E, Van Paesschen, W, Johnson, ME, Lu, S. Adjunctive brivaracetam for uncontrolled focal and generalized epilepsies: results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trial. Epilepsia 2014; 55: 3846.CrossRefGoogle ScholarPubMed
Lattanzi, S, Cagnetti, C, Foschi, N, Provinciali, L, Silvestrini, M. Brivaracetam add-on for refractory focal epilepsy: a systematic review and meta-analysis. Neurology 2016; 86: 13441352.CrossRefGoogle ScholarPubMed
Ma, J, Huang, S, You, C. Adjunctive brivaracetam for patients with refractory partial seizures: a meta-analysis of randomized placebo-controlled trials. Epilepsy Research 2015; 114: 5965.CrossRefGoogle ScholarPubMed
Ryvlin, P, Werhahn, KJ, Blaszczyk, B, Johnson, ME, Lu, S. Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trial. Epilepsia 2014; 55: 4756.CrossRefGoogle ScholarPubMed
Schoemaker, R, Wade, JR, Stockis, A. Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years. European Journal of Clinical Pharmacology 2017; 73: 727733.CrossRefGoogle ScholarPubMed
Stockis, A, Sargentini-Maier, ML, Brodie, MJ. Pharmacokinetic interaction between brivaracetam on carbamazepine in adult patients with epilepsy, with and without valproate co-administration. Epilepsy Research 2016; 128: 163168.CrossRefGoogle ScholarPubMed
Toledo, M, Whitesides, J, Schiemann, J, Johnson, ME, Eckhardt, K, McDonough, B, Borghs, S, Kwan, P. Safety, tolerability, and seizure control during long-term treatment with adjunctive brivaracetam for partial-onset seizures. Epilepsia 2016; 57: 11391151.CrossRefGoogle ScholarPubMed

Send book to Kindle

To send this book to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats

Send book to Dropbox

To send content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Dropbox.

Available formats

Send book to Google Drive

To send content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Google Drive.

Available formats