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Case 47 - Is It Still Helping?

from Part 10 - Management Misadventures

Published online by Cambridge University Press:  03 November 2020

Keith Josephs
Affiliation:
Mayo Clinic Alzheimer’s Disease Research Center
Federico Rodriguez-Porcel
Affiliation:
Medical University of South Carolina
Rhonna Shatz
Affiliation:
University of Cincinnati
Daniel Weintraub
Affiliation:
University of Pennsylvania
Alberto Espay
Affiliation:
University of Cincinnati
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Summary

This 76-year-old man returned to the clinic, brought by his daughter for monitoring of his progressive memory impairment. Five years previously, neuropsychological evaluation revealed memory encoding deficits and brain MRI showed asymmetric hippocampal atrophy. With a diagnosis of probable Alzheimer disease, he was started on rivastigmine, gradually increased to a dose of 6 mg BID. The family noticed better thinking and less forgetfulness for six months, but he continued to decline thereafter. He went on to have difficulty dressing and bathing and experienced delusions of theft. After five years of treatment with rivastigmine, his daughter wondered if it should be discontinued.

Type
Chapter
Information
Common Pitfalls in Cognitive and Behavioral Neurology
A Case-Based Approach
, pp. 153 - 154
Publisher: Cambridge University Press
Print publication year: 2020

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References

Daiello, L. A. et al. 2009. Effect of discontinuing cholinesterase inhibitor therapy on behavioral and mood symptoms in nursing home patients with dementia. Am J Geriatr Pharmacother 7(2) 7483.CrossRefGoogle Scholar
Doody, R. S. et al. 2001. Open-label, multicenter, phase 3 extension study of the safety and efficacy of donepezil in patients with Alzheimer disease. Arch Neurol 58(3) 427433.CrossRefGoogle ScholarPubMed
Ferris, S. H. and Farlow, M. 2013. Language impairment in Alzheimer’s disease and benefits of acetylcholinesterase inhibitors. Clin Interv Aging 8 10071014.CrossRefGoogle ScholarPubMed
Howard, R. et al. 2012. Donepezil and memantine for moderate-to-severe Alzheimer’s disease. N Engl J Med 366(10) 893903.CrossRefGoogle ScholarPubMed
Lanctôt, K. et al. 2015. Predictors of worsening following cholinesterase inhibitor discontinuation trial in institutionalized persons with moderate to severe Alzheimer’s disease: results of a double-blind, placebo controlled trial. Alzheimer’s Dementia 11(7) P520.CrossRefGoogle Scholar
Pariente, A. et al. 2012. Effect of treatment gaps in elderly patients with dementia treated with cholinesterase inhibitors. Neurology 78(13) 957963.CrossRefGoogle ScholarPubMed
Scarpini, E. et al. 2011. Cessation versus continuation of galantamine treatment after 12 months of therapy in patients with Alzheimer’s disease: a randomized, double blind, placebo controlled withdrawal trial. J Alzheimers Dis 26(2) 211220.CrossRefGoogle ScholarPubMed

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