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Chapter 13 - Cerebral microbleeds and Alzheimer'sdisease

from Section 3 - Microbleeds in relation to specific populations, diseases and neurological symptoms

Published online by Cambridge University Press:  05 July 2011

David J. Werring
Affiliation:
Institute of Neurology, London
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Summary

In Alzheimer's disease (AD), cerebral microbleeds (CMBs) play a crucial role in the pathophysiology of the disorder. This chapter reviews the available data that help in considering the meaning of CMBs in clinical terms and the underlying pathology in the context of AD. Evidence on the underlying pathology of CMBs can be sought from neuropathology studies, anatomical distribution in AD and clinical studies on related factors. Most studies on CMBs in AD demonstrated a cortico-subcortical predominance, but with some patients exhibiting CMBs both in deep and cortico-subcortical locations. Cerebral microbleeds are strongly linked to hypertensive vasculopathy. With studies on the relevance of CMBs in AD emerging, CMBs have become a factor of interest in the design of clinical trials, particularly with regard to the new generation of immunization therapies, which have been linked to the development of new CMBs.
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Cerebral Microbleeds
Pathophysiology to Clinical Practice
, pp. 117 - 124
Publisher: Cambridge University Press
Print publication year: 2011

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