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38B - Genome Editing Should Be Allowed for the Prevention of Life-Threatening Genetic Diseases

Against

from Section VII - Genetics

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

Arguments against the use of germline genome editing (GGE) frequently centre on deontological debates about ‘designer babies’ or human nature. While important, there is a more fundamental reason to be opposed to GGE, namely violations to the principle of health equality and distributive justice. Here, we will argue from a more consequentialist framework: 1. GGE does not meet the ethical requirements of clinical research and translation; 2. GGE will exacerbate existing disparities in access to research and health care; 3. GGE will exacerbate the stigmatisation and marginalisation of those living with health conditions; 4. GGE divert significant resources away from effective solutions to broader public health concerns;

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2021

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References

Davies, B. The technical risks of human gene editing. Hum Reprod. 2019;34(11):2104–11.CrossRefGoogle ScholarPubMed
Ormond, KE, Bombard, Y, Bonham, VL, et al. The clinical application of gene editing: ethical and social issues. Per Med. 2019;16(4):337–50.CrossRefGoogle ScholarPubMed
Ledford, H. CRISPR gene editing in human embryos wreaks chromosomal mayhem. Nature. 2020;583(7814):1718.CrossRefGoogle ScholarPubMed
Mintz, RL, Loike, JD, Fischbach, RL. Will CRISPR germline engineering close the door to an open future? Sci Engin Ethics. 2019;25(5):1409–23.CrossRefGoogle Scholar
Smith, CE, Fullerton, SM, Dookeran, KA, et al. Using genetic technologies to reduce, rather than widen, health disparities. Health Aff (Millwood). 2016;35(8):1367–73.CrossRefGoogle ScholarPubMed

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