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Brain function mediates the association between low vitamin D and neurocognitive status in female patients with major depressive disorder

Published online by Cambridge University Press:  01 April 2022

Wenming Zhao ,
Dao-min Zhu ,
Qian Li ,
Xiaotao Xu ,
Yu Zhang ,
Cun Zhang ,
Jiajia Zhu  and
Yongqiang Yu
Wenming Zhao
Affiliation:
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, China Anhui Provincial Institute of Translational Medicine, Hefei 230032, China
Dao-min Zhu
Affiliation:
Department of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei 230022, China Hefei Fourth People's Hospital, Hefei 230022, China Anhui Mental Health Center, Hefei 230022, China
Qian Li
Affiliation:
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, China Anhui Provincial Institute of Translational Medicine, Hefei 230032, China
Xiaotao Xu
Affiliation:
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, China Anhui Provincial Institute of Translational Medicine, Hefei 230032, China
Yu Zhang
Affiliation:
Department of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei 230022, China Hefei Fourth People's Hospital, Hefei 230022, China Anhui Mental Health Center, Hefei 230022, China
Cun Zhang
Affiliation:
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, China Anhui Provincial Institute of Translational Medicine, Hefei 230032, China
Jiajia Zhu*
Affiliation:
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, China Anhui Provincial Institute of Translational Medicine, Hefei 230032, China
Yongqiang Yu*
Affiliation:
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, China Anhui Provincial Institute of Translational Medicine, Hefei 230032, China
*
Author for correspondence: Yongqiang Yu, E-mail: cjr.yuyongqiang@vip.163.com; Jiajia Zhu, E-mail: zhujiajiagraduate@163.com
Author for correspondence: Yongqiang Yu, E-mail: cjr.yuyongqiang@vip.163.com; Jiajia Zhu, E-mail: zhujiajiagraduate@163.com
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Abstract

Background

Vitamin D is engaged in various neural processes, with low vitamin D linked to depression and cognitive dysfunction. There are gender differences in depression and vitamin D level. However, the relationship between depression, gender, vitamin D, cognition, and brain function has yet to be determined.

Methods

One hundred and twenty-two patients with major depressive disorder (MDD) and 119 healthy controls underwent resting-state functional MRI and fractional amplitude of low-frequency fluctuations (fALFF) was calculated to assess brain function. Serum concentration of vitamin D (SCVD) and cognition (i.e. prospective memory and sustained attention) were also measured.

Results

We found a significant group-by-gender interaction effect on SCVD whereby MDD patients showed a reduction in SCVD relative to controls in females but not males. Concurrently, there was a female-specific association of SCVD with cognition and MDD-related fALFF alterations in widespread brain regions. Remarkably, MDD- and SCVD-related fALFF changes mediated the relation between SCVD and cognition in females.

Conclusion

Apart from providing insights into the neural mechanisms by which low vitamin D contributes to cognitive impairment in MDD in a gender-dependent manner, these findings might have clinical implications for assignment of female patients with MDD and cognitive dysfunction to adjuvant vitamin D supplementation therapy, which may ultimately advance a precision approach to personalized antidepressant choice.

Keywords

Brain functioncognitionfMRIgendermajor depressive disordervitamin D
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 9 , July 2023 , pp. 4032 - 4045
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work.

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