To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Since mechanisms of action of the approved therapies for multiple sclerosis (MS) involve anti-inflammatory effects, and since these treatments result primarily in a reduction in relapse rates, it is logical to hypothesize that mechanisms of action of the protective effect of pregnancy on MS relapses involve anti-inflammatory effects. Two estrogens (estradiol and estriol) and progesterone each increase progressively during pregnancy. Levels of estrogens that are in oral contraceptives or hormone replacement therapy may not be high enough to be protective in MS. Numerous factors other than sex hormones have been identified in sera during pregnancy and have been shown to be immunosuppressive either in cultures of immune cells in vitro or in experimental autoimmune encephalomyelitis (EAE) models. The combined anti-inflammatory and neuroprotective state of pregnancy, perhaps aimed at protecting the fetus, may be precisely what is needed to protect the central nervous system (CNS) of a mother with MS.
Email your librarian or administrator to recommend adding this to your organisation's collection.