A surfactant-covered droplet on a solid surface subject to a three-dimensional shear flow is studied using a lattice-Boltzmann and finite-difference hybrid method, which allows for the surfactant concentration beyond the critical micelle concentration. We first focus on low values of the effective capillary number ( $Ca_{e}$ ) and study the effect of $Ca_{e}$ , viscosity ratio ( $\unicode[STIX]{x1D706}$ ) and surfactant coverage on the droplet behaviour. Results show that at low $Ca_{e}$ the droplet eventually reaches steady deformation and a constant moving velocity $u_{d}$ . The presence of surfactants not only increases droplet deformation but also promotes droplet motion. For each $\unicode[STIX]{x1D706}$ , a linear relationship is found between contact-line capillary number and $Ca_{e}$ , but not between wall stress and $u_{d}$ due to Marangoni effects. As $\unicode[STIX]{x1D706}$ increases, $u_{d}$ decreases monotonically, but the deformation first increases and then decreases for each $Ca_{e}$ . Moreover, increasing surfactant coverage enhances droplet deformation and motion, although the surfactant distribution becomes less non-uniform. We then increase $Ca_{e}$ and study droplet breakup for varying $\unicode[STIX]{x1D706}$ , where the role of surfactants on the critical $Ca_{e}$ ( $Ca_{e,c}$ ) of droplet breakup is identified by comparing with the clean case. As in the clean case, $Ca_{e,c}$ first decreases and then increases with increasing $\unicode[STIX]{x1D706}$ , but its minima occurs at $\unicode[STIX]{x1D706}=0.5$ instead of $\unicode[STIX]{x1D706}=1$ in the clean case. The presence of surfactants always decreases $Ca_{e,c}$ , and its effect is more pronounced at low $\unicode[STIX]{x1D706}$ . Moreover, a decreasing viscosity ratio is found to favour ternary breakup in both clean and surfactant-covered cases, and tip streaming is observed at the lowest $\unicode[STIX]{x1D706}$ in the surfactant-covered case.

The surface topology of biomaterial has a definite effect on the growth behavior of nerve cells for peripheral nerve regeneration. In this study, the silk fibroin (SF) film with different anisotropic microgroove/ridge was constructed by micropatterning technology. The effects of topologies width on the directional growth of dorsal root ganglion (DRG) neurons were evaluated. The results showed that the topological structure of the SF film with higher SF concentration was more clear and complete. The microtopography of the SF film with a concentration of 15% and a groove width of around 30 μm could effectively guide the directional growth of the nerve fibers of DRG. And nerve fibers could obviously form nerve fiber bundles which may have a certain pavement effect on the recovery of nerve function. The study indicated that the SF film with a specific width of the topological structure may have potential applications in the field of directional nerve regeneration.

Electrospun membranes have potential applications in the field of waterproof and breathable textile products. However, challenges still exist to improve the breathability, and waterproof and mechanical properties of these microporous membranes. In this paper, a novel hydrophobic microporous nanofiber membrane was prepared via side-by-side electrospinning of fluorosilane-modified silica nanoparticles (F–SiO2) blended with synthesized polyurethane (PU) solution and composited with the polyacrylonitrile (PAN) solution. To prepare F–SiO2, SiO2 nanoparticles were hydrophobically modified by fluorosilane. Composite nanofiber membranes with different blending ratios of PU(F–SiO2)/PAN were fabricated via side-by-side electrospinning by controlling the extruding speed of two spinnerets. Experimental results indicated that regarding F–SiO2 as hydrophobic inorganic particle can improve the hydrophobic properties of PU nanofiber membrane. The prepared PAN/(F–SiO2/PU) nanofiber microporous membranes exhibit relatively excellent waterproof and mechanical properties as that robust tensile strength (19.5 MPa), preferable water vapor permeability [10.3 kg/(m2 d)], favorable water contact angle (137.2°), and superior mechanical properties. It was believed that the reinforced PAN/(F–SiO2/PU) nanofibrous composite membranes have potential applications in chemical protective clothing, army combat uniforms, self-cleaning materials, and other medical products.

Introduction: Patients with poorly-controlled diabetes often visit the emergency department (ED) for treatment of hyperglycemia. While previous qualitative studies have examined the patient experience of diabetes as a chronic illness, there are no studies describing patients’ perceptions of ED care for hyperglycemia. The objective of this study was to explore the patient experience regarding ED hyperglycemia visits, and to characterize perceived barriers to adequate glycemic control post-discharge. Methods: This study was conducted at a tertiary care academic centre in London, Ontario. A qualitative constructivist grounded theory methodology was used to understand the experience of adult patient partners who have had an ED hyperglycemia visit. Patient partners, purposively sampled to capture a breadth of age, sex, disease and presentation frequency were invited to participate in a semi-structured individual interview to probe their experiences. Sampling continued until a theoretical framework representing key experiences and expectations reached sufficiency. Data were collected and analyzed iteratively using a constant comparative approach. Results: 22 patients with type 1 or 2 diabetes were interviewed. Participants sought care in the ED over other options because of their concern of having a potentially life-threatening condition, advice from a healthcare provider or family member, or a perceived lack of convenient alternatives to the ED based on time and location. Participants’ care expectations centred around symptom relief, glycemic control, reassurance and education, and seeking referral to specialist diabetes care post-discharge. Finally, perceived system barriers that challenged participants’ glycemic control included affordability of medical supplies and medications, access to follow-up and, in some cases, the transition from pediatric to adult diabetes care. Conclusion: Patients with diabetes utilize the ED for a variety of urgent and emergent hyperglycemic concerns. In addition to providing excellent medical treatment, ED healthcare providers should consider patients’ expectations when caring for those presenting with hyperglycemia. Future studies will focus on developing strategies to help patients navigate some of the barriers that exist within our current limited healthcare system, enhance follow-up care, and improve short- and long-term health outcomes.

At the forefront of developments in synchrotron x-ray microscopy, nanoscale-resolution high-dimensional spectrotomography under controlled sample environments has been demonstrated. Such cutting-edge experimental capability has been broadly applied to scientific studies in the field of energy materials science, where the dynamically evolving structural and chemical defects play a vital role in the functionality. In this article, we review novel developments of this technique from both experimental and data/information mining perspectives. Using studies on lithium-ion battery electrode materials as examples, we highlight the rich information in the high-dimensional and high-resolution x-ray tomographic data, which can be used to interpret the complicated thermal-electro-chemo-mechanical interplay that occurs under the operating conditions and collectively determines battery performance. We also discuss the frontier challenges in this field and our perspectives of the future directions in the context of projected major developments in the landscape of large-scale x-ray facilities across the globe.

We aimed to evaluate the relationship of plasma Mg with the risk of new-onset hyperuricaemia and examine any possible effect modifiers in hypertensive patients. This is a post hoc analysis of the Uric acid (UA) Sub-study of the China Stroke Primary Prevention Trial (CSPPT). A total of 1685 participants were included in the present study. The main outcome was new-onset hyperuricaemia defined as a UA concentration ≥417 μmol/l in men or ≥357 μmol/l in women. The secondary outcome was a change in UA concentration defined as UA at the exit visit minus that at baseline. During a median follow-up duration of 4·3 years, new-onset hyperuricaemia occurred in 290 (17·2 %) participants. There was a significantly inverse relation of plasma Mg with the risk of new-onset hyperuricaemia (per sd increment; OR 0·85; 95 % CI 0·74, 0·99) and change in UA levels (per sd increment; β −3·96 μmol/l; 95 % CI −7·14, −0·79). Consistently, when plasma Mg was analysed as tertiles, a significantly lower risk of new-onset hyperuricaemia (OR 0·67; 95 % CI 0·48, 0·95) and less increase in UA levels (β −8·35 μmol/l; 95 % CI −16·12, −0·58) were found among participants in tertile 3 (≥885·5 μmol/l) compared with those in tertile 1 (<818·9 μmol/l). Similar trends were found in males and females. Higher plasma Mg levels were associated with a decreased risk of new-onset hyperuricaemia in hypertensive adults.

The findings for the roles of dairy products, calcium, and vitamin D on ovarian cancer risk remain controversial. We aimed to assess these associations by using an updated meta-analysis. Five electronic databases (e.g., PubMed and Embase) were searched from inception to December 24, 2019. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated. A total of 29 case–control or cohort studies were included. For comparisons of the highest vs. lowest intakes, higher whole milk intake was associated with increased ovarian cancer risk (RR: 1.35, 95% CI: 1.15, 1.59), whereas decreased risks were observed for higher intakes of low-fat milk (RR: 0.84, 95% CI: 0.73, 0.96), dietary calcium (RR: 0.71, 95% CI: 0.60, 0.84), and dietary vitamin D (RR: 0.80, 95% CI: 0.67, 0.95). Additionally, for every 100-g/d increment, increased ovarian cancer risks were found for total dairy products (RR: 1.03, 95% CI: 1.01, 1.04) and for whole milk (RR: 1.07, 95% CI: 1.03, 1.11); however, decreased risks were found for a 100-g/d increased intakes of low-fat milk (RR: 0.95, 95% CI: 0.91, 0.99), cheese (RR: 0.87, 95% CI: 0.76, 0.98), dietary calcium (RR: 0.96, 95% CI: 0.95, 0.98), total calcium (RR: 0.98, 95% CI: 0.97, 0.99), dietary vitamin D (RR: 0.92, 95% CI: 0.87, 0.97), and increased levels of circulating vitamin D (RR: 0.84, 95% CI: 0.72, 0.97). These results show that whole milk intake might contribute to a higher ovarian cancer risk, whereas low-fat milk, dietary calcium, and dietary vitamin D might reduce the risk.

Varicella is an acute respiratory infectious diseases, with high transmissibility and quick dissemination. In this study, an SEIR (susceptible-exposed-infected-recovered) dynamic model was established to explore the optimal prevention and control measures according to the epidemiological characteristics about varicella outbreak in a school in a central city of China. Berkeley Madonna 8.3.18 and Microsoft Office Excel 2010 software were employed for the model simulation and data management, respectively. The result showed that the simulated result of SEIR model agreed well with the reported data when β (infected rate) equal to 0.067. Models showed that the cumulative number of cases was only 13 when isolation adopted when the infected individuals were identified (assuming isolation rate was up to 100%); the cumulative number of cases was only two and the TAR (total attack rate) was 0.56% when the vaccination coefficient reached 50%. The cumulative number of cases did not change significantly with the change of efficiency of ventilation and disinfection, but the peak time was delayed; when δ (vaccination coefficient) = 0.1, m (ventilation efficiency) = 0.7 or δ = 0.2, m = 0.5 or δ = 0.3, m = 0.1 or δ = 0.4 and above, the cumulative number of cases would reduce to one case and TAR would reduce to 0.28% with combined interventions. Varicella outbreak in school could be controlled through strict isolation or vaccination singly; combined interventions have been adopted when the vaccination coefficient was low.

Collision avoidance for robots and vehicles in unpredictable environments is a challenging task. Various control strategies have been developed for the agent (i.e., robots or vehicles) to sense the environment, assess the situation, and select the optimal actions to avoid collision and accomplish its mission. In our research on autonomous ships, we take a machine learning approach to collision avoidance. The lack of available ship steering data of human ship masters has made it necessary to acquire collision avoidance knowledge through reinforcement learning (RL). Given that the learned neural network tends to be a black box, it is desirable that a method is available which can be used to design an agent's behavior so that the desired knowledge can be captured. Furthermore, RL with complex tasks can be either time consuming or unfeasible. A multi-stage learning method is needed in which agents can learn from simple tasks and then transfer their learned knowledge to closely related but more complex tasks. In this paper, we explore the ways of designing agent behaviors through tuning reward functions and devise a transfer RL method for multi-stage knowledge acquisition. The computer simulation-based agent training results have shown that it is important to understand the roles of each component in a reward function and the various design parameters in transfer RL. The settings of these parameters are all dependent on the complexity of the tasks and the similarities between them.

Pancreatic cancer is currently one of the most lethal tumors because of delayed diagnosis and treatment. Aminopeptidase N (CD13/APN), expressed in pancreatic cancer cells, is closely related to the malignant biological behavior, for instance, angiogenesis formation, tumor proliferation, and metastasis. In this study, asparagine–glycine–arginine (Asn–Gly–Arg, NGR), selectively binding to CD13 receptor, was modified to construct a novel contrast agent of QDs@Gd3+-NGR for targeted diagnosis and treatment of pancreatic cancer. It consists of QDs-unit for fluorescence imaging, Gd3+-unit for magnetic resonance imaging (MRI), and NGR for binding to CD13 receptor. PANC-1 cells labeled by QDs@Gd3+-NGR showed significant red fluorescence and high intensity on fluorescence and MR imaging, respectively. Besides, it was confirmed that QDs@Gd3+-NGR could inhibit theproliferation, metastasis, and invasion of PANC-1 cells, and increase reactive oxygen species production and death rate in vitro. Reasonably, we believe the targeted contrast agent of QDs@Gd3+-NGR can sensitively detect pancreatic cancer via MR-fluorescence dual-modality imaging, and plays an active role in inhibition of tumor progression. The promising results in this study provide integration of diagnostic and therapeutic strategy for the management of pancreatic cancer in future.