This paper outlines some of the radio frequency interference issues related to radio astronomy performed with space-based radio telescopes. Radio frequency interference that threatens radio astronomy observations from the surface of Earth will also degrade observations with space-based radio telescopes. However, any resulting interference could be different than for ground-based telescopes due to several factors. Space radio astronomy observations significantly enhance studies in different areas of astronomy. Several space radio astronomy experiments for studies in low-frequency radio astronomy, space VLBI, the cosmic microwave background and the submillimetre wavelengths have flown already. The first results from these missions have provided significant breakthroughs in our understanding of the nature of celestial radio radiation. Radio astronomers plan to deploy more radio telescopes in Earth orbit, in the vicinity of the L
2 Sun-Earth Lagrangian point, and, in the more distant future, in the shielded zone of the Moon.