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Reward Deficiency Syndrome (RDS) is an umbrella term for all drug and nondrug addictive behaviors, due to a dopamine deficiency, “hypodopaminergia.” There is an opioid-overdose epidemic in the USA, which may result in or worsen RDS. A paradigm shift is needed to combat a system that is not working. This shift involves the recognition of dopamine homeostasis as the ultimate treatment of RDS via precision, genetically guided KB220 variants, called Precision Behavioral Management (PBM). Recognition of RDS as an endophenotype and an umbrella term in the future DSM 6, following the Research Domain Criteria (RDoC), would assist in shifting this paradigm.
This volume explores journeys across time and space in Greek and Latin literature, taking as its starting point the paradigm of travel offered by the epic genre. The epic journey is central to the dynamics of classical literature, offering a powerful lens through which characters, authors, and readers experience their real and imaginary worlds. The journey informs questions of identity formation, narrative development, historical emplotment, and constructions of heroism - topics that move through and beyond the story itself. The act of moving to and from 'home' - both a fixed point of spatial orientation and a transportable set of cultural values - thus represents a physical journey and an intellectual process. In exploring its many manifestations, the chapters in this collection reconceive the centrality of the epic journey across a wide variety of genres and historical contexts, from Homer to the moon.