A new and important model for international health originated in the 1920s as a rural health project in the Macedonian region of Yugoslavia. Thus, the involvement of international organisations in social stability and human security did not follow the Great Depression of the 1930s, as has been argued. In fact, the redefinition of the League of Nations’ mandate began with its Health Organisation in the 1920s, growing from local health projects. These initiatives adapted principles of social medicine to address the challenges of constructing egalitarian democratic states in the agrarian peripheries of post-imperial Europe.