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There is a growing trend for studies run by academic and nonprofit organizations to have regulatory submission requirements. As a result, there is greater reliance on REDCap, an electronic data capture (EDC) widely used by researchers in these organizations. This paper discusses the development and implementation of the Rapid Validation Process (RVP) developed by the REDCap Consortium, aimed at enhancing regulatory compliance and operational efficiency in response to the dynamic demands of modern clinical research. The RVP introduces a structured validation approach that categorizes REDCap functionalities, develops targeted validation tests, and applies structured and standardized testing syntax. This approach ensures that REDCap can meet regulatory standards while maintaining flexibility to adapt to new challenges. Results from the application of the RVP on recent successive REDCap software version releases illustrate significant improvements in testing efficiency and process optimization, demonstrating the project’s success in setting new benchmarks for EDC system validation. The project’s community-driven responsibility model fosters collaboration and knowledge sharing and enhances the overall resilience and adaptability of REDCap. As REDCap continues to evolve based on feedback from clinical trialists, the RVP ensures that REDCap remains a reliable and compliant tool, ready to meet regulatory and future operational challenges.
Declining labor force participation of older men throughout the 20th century and recent increases in participation have generated substantial interest in understanding the effect of public pensions on retirement. The National Bureau of Economic Research's International Social Security (ISS) Project, a long-term collaboration among researchers in a dozen developed countries, has explored this and related questions. The project employs a harmonized approach to conduct within-country analyses that are combined for meaningful cross-country comparisons. The key lesson is that the choices of policy makers affect the incentive to work at older ages and these incentives have important effects on retirement behavior.
The characterization of poorly crystalline minerals formed by weathering is difficult using conventional techniques. The objective of this study was to use cutting-edge spectroscopic techniques to characterize secondary Fe mineralogy in young soils formed in basaltic cinders in a cool, arid environment. The mineralogy of a chronosequence of soils formed on 2, 6, and 15 thousand year old basaltic cinders at Craters of the Moon National Monument (COM) was examined using synchrotron-based X-ray absorption fine structure (XAFS) spectroscopy in combination with selective extractions. Fe K-edge XAFS is useful for determining speciation in poorly crystalline materials such as young weathering products. Over 86% of Fe in the soil clay fractions was contained in poorly crystalline materials, mostly in the form of ferrihydrite, with the remainder in a poorly crystalline Fe-bearing smectite. The XAFS spectra suggest that ferrihydrite in the 15 ka soil clay is more resistant to ammonium oxalate (AOD) extraction than is ferrihydrite in the younger materials. Fe in the poorly crystalline smectite is subject to dissolution during citrate-bicarbonate- dithionite (CBD) extraction. The results indicate that relatively few mineralogical changes occur in these soils within the millennial time frame and under the environmental conditions associated with this study. Although the secondary mineral suite remains similar in the soils of different ages, ferrihydrite crystallinity appears to increase with increasing soil age.
It is acknowledged that health technology assessment (HTA) is an inherently value-based activity that makes use of normative reasoning alongside empirical evidence. But the language used to conceptualise and articulate HTA's normative aspects is demonstrably unnuanced, imprecise, and inconsistently employed, undermining transparency and preventing proper scrutiny of the rationales on which decisions are based. This paper – developed through a cross-disciplinary collaboration of 24 researchers with expertise in healthcare priority-setting – seeks to address this problem by offering a clear definition of key terms and distinguishing between the types of normative commitment invoked during HTA, thus providing a novel conceptual framework for the articulation of reasoning. Through application to a hypothetical case, it is illustrated how this framework can operate as a practical tool through which HTA practitioners and policymakers can enhance the transparency and coherence of their decision-making, while enabling others to hold them more easily to account. The framework is offered as a starting point for further discussion amongst those with a desire to enhance the legitimacy and fairness of HTA by facilitating practical public reasoning, in which decisions are made on behalf of the public, in public view, through a chain of reasoning that withstands ethical scrutiny.
In this chapter we introduce the topic and aims of the book and define key terms such as anxiety, corpus linguistics and discourse. We provide the motivation for writing the book and outline other studies which have examined language in healthcare contexts, in particular focusing on studies which have looked at healthcare forums and/or mental health issues, as well as studies which have used corpus linguistics techniques for corpus-assisted discourse analysis. We then outline the research questions which drive the analysis in the book. We introduce the corpus that we worked with and discuss ethical issues in dealing with online data, as well as issues relating to data processing. We also provide a description of the tools and techniques that we used to carry out our analysis. We then reflect on our own position in relationship to the topic we are researching. Finally, we provide an outline of the remaining chapters of the book.
Here, we consider the interactive and online affordances of the forum by looking at the ways that posters respond to each other’s posts. What kind of language use characterises those which receive numerous responses vs those which receive none at all? We also ask, how do posters reach consensus and, considering the range of posts of people from different backgrounds, how is disagreement around understandings of anxiety negotiated? We code a sample of the forum posts using Egbert et al.’s (2021) coding scheme for functional discourse units. This is based on nine codes which indicate the particular purpose of a stretch of interactive text; for example, joking around, engaging in conflict or giving advice. Additionally, we look at uses of computer-mediated communication, including acronyms such as lol and emojis which are often used for affiliative purposes and disambiguation. This chapter uses corpus-based frequency approaches to identify longer stretches of interaction which are then examined qualitatively.
Our analysis begins with a focus on the word anxiety, using the corpus analysis tool Sketch Engine to provide a detailed ‘Word Sketch’ of its use in the forum; for example, looking at its occurrence in different grammatical patterns. This analysis identified four clines in terms of how anxiety is discursively constructed: 1) catastrophisation vs minimisation (e.g., some patients refer to having terrible anxiety while others downplay their condition using phrases such as it’s just anxiety); 2) medicalisation vs non-medicalisation (e.g., use of medical terminology such as anxiety disorder vs colloquial expressions such as anxiety crap); 3) personalisation vs impersonalisation (e.g., some posters represent their anxiety as a conscious being with its own wants and grammatical agency, such as anxiety is playing mind games with them, while others represent anxiety as an abstract concept, such as as an illness); and 4) internalisation vs externalisation (e.g., some people claim their anxiety is part of themselves – my anxiety – while others refer to it as something separate – the anxiety monster).
In this chapter we compare posts from the two countries which most posters identified as residing in. Within the forum, 38.84% of posts were made by people from the UK, 33.94% were made by those from the USA, 17.41% were made by people who did not specify a country and 9.81% consisted of all other countries. While the main language in the UK and USA is English, an analysis of keyword differences indicates numerous differences which point not only to spelling (favorite) and lexical choices (vacation) but also to ways that anxiety is understood. In addition, we consider the extent to which posters are influenced by external cultures; for example, is there evidence that British posters are adopting language and discourses used by American posters, or vice versa? As with the previous chapter, the analysis concludes by considering the role of culture on understandings of anxiety.
The concluding chapter of this monograph summarises the main findings from the preceding chapters and brings those findings together to establish overall patterns and trends in online discourses of anxiety. Concordant with our Critical Discourse Studies approach, these representations are then related to the contexts in which they are situated as well as their implications for understanding mental health in wider society. The chapter also critically reflects on the approach we took, the questions that emerged as a result of engaging with the corpus of forum posts and potential extensions to our study.
In this chapter we delve deeper into forum posters’ descriptions of anxiety by focusing on how they describe what it feels like to experience anxiety, what they believe causes their anxiety and how they best believe that their anxiety can be resolved. We consider also patient narratives around their anxiety. This chapter provides an overview of the linguistic content of the forum by carrying out a keywords analysis of the online corpus to identify words and phrases that are statistically salient in forum posts, comparing first posts with subsequent posts. These words are placed into thematic categories and a representative set are analysed in depth to illustrate different aspects of discussion around anxiety.
In this chapter we make use of the demographically tagged nature of the forum posts by comparing and contrasting posts made by female and male users. Some 52.02% of posts were made by posters who identified as female, 16.71% were made by male posters and 31.20% were made by posters who did not specify their sex. These figures are congruent with data on prevalence of anxiety by sex, which tends to indicate that women are more likely than men to be diagnosed with anxiety. We examine male and female keywords in the corpus, finding that men are more likely to use problem-solving language that focuses on explanations for anxiety and strategies for resolving it. On the other hand, women are more likely to use affiliative language to express empathy, sympathy and encouragement to others. The chapter also examines gendered discourses relating to anxiety by considering representations around words such as man, woman, macho and feminine. Our analysis concludes by linking our findings to consideration of gendered roles and societal stereotypes.