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We show how a complete mathematical model of a physical process can be learned directly from data via a hybrid approach combining three simple and general ingredients: physical assumptions of smoothness, locality and symmetry, a weak formulation of differential equations and sparse regression. To illustrate this, we extract a complete system of governing equations of fluid dynamics – the Navier–Stokes equation, the continuity equation and the boundary conditions – as well as the pressure-Poisson and energy equations, from numerical data describing a highly turbulent channel flow in three dimensions. Whether they represent known or unknown physics, relations discovered using this approach take the familiar form of partial differential equations, which are easily interpretable and readily provide information about the relative importance of different physical effects. The proposed approach offers insight into the quality of the data, serving as a useful diagnostic tool. It is also remarkably robust, yielding accurate results for very high noise levels, and should thus be well suited for analysis of experimental data.
Complications following the Fontan procedure include prolonged pleural drainage and readmission for effusions. To address these complications, a post-Fontan management pathway was implemented with primary goals of reducing chest tube duration/reinsertion rates and decreasing hospital length of stay and readmissions.
Methods:
Fontan patients were identified by retrospective chart review (2017–2019) to obtain baseline data for chest tube duration/reinsertion rates, hospital length of stay, and readmission rates for effusion. A post-Fontan management pathway was implemented (2020–2021) utilising post-operative vasopressin, nasal cannula oxygen until chest tube removal, and discharge regimen of three times daily diuretics, sildenafil, and afterload reducing medications. Patients were followed to evaluate primary outcomes.
Results:
The pre- and post-pathway groups were similar in single ventricle morphology, demographics, and pre-operative haemodynamics. Forty-three and 36 patients were included in the pre- and post-pathway cohorts, respectively. There were statistically significant reductions in chest tube duration (8 vs. 5 days, p ≤ 0.001), chest tube output on post-operative day 4 (20.4 vs. 9.9 mL/kg/day, p = 0.003), and hospital readmission rates for effusion (13[30%] vs. 3[8%], p = 0.02) compared to baseline. There was an absolute reduction in hospital length of stay (11 vs. 9.5 days, p = 0.052). When combining average cost savings for the Fontan hospitalisations, readmissions for effusion, and cardiac catheterisations within 6 months of Fontan completion, there was a $325,144 total cost savings for 36 patients following pathway implementation.
Conclusion:
Implementation of a post-Fontan management pathway resulted in significant reductions in chest tube duration and output, and readmission rates for effusion in the perioperative period.
Projected increases in human population suggest that 70% more food will be needed in the near future, this makes it imperative to search for alternative food and feed sources for human and animal nutrition to feed the exponentially growing human population. According to the FAO 2019 report, the immense challenge of achieving the Zero Hunger target by 2030 is persistent. Exploring the unexplored, refining unrefined traits, cultivating the uncultivated, and popularizing the unpopular remain the most adequate steps proposed by researchers to achieve the domestication of the undomesticated for food and nutrition security. In that line of thought, this study explored the proximate composition of 87 accessions of four wild unexplored Vigna species (V. racemosa, V. ambacensis, V. reticulata, V. vexillata) in order to reveal information leading to their future domestication and utilization. Standard procedures and methods approved by the Association of Official Analytical Chemists were used in carrying out the proximate composition (%protein, %lipid, %fibre, %ash and % moisture and % carbohydrate) of the wild Vigna legumes. The study revealed that the wild Vigna species possess a large variation range of nutrient characteristics which could be exploited in the improvement of domesticated species or guide their domestication. It was also found that some individual wild accessions have higher nutrient, content as compared with domesticated ones which could be advantageous for bio-fortification or domestication. Indications relating to the candidate accessions favourable for domestication, based on the nutrient characteristics were revealed.
Operational Risk is one of the most difficult risks to model. It is a large and diverse category covering anything from cyber losses to mis-selling fines; and from processing errors to HR issues. Data is usually lacking, particularly for low frequency, high impact losses, and consequently there can be a heavy reliance on expert judgement. This paper seeks to help actuaries and other risk professionals tasked with the challenge of validating models of operational risks. It covers the loss distribution and scenario-based approaches most commonly used to model operational risks, as well as Bayesian Networks. It aims to give a comprehensive yet practical guide to how one may validate each of these and provide assurance that the model is appropriate for a firm’s operational risk profile.
Predicting future conservation needs can help inform conservation management but is subject to uncertainty. We measured deforestation rates during 2015–2017 for 114 protected areas in Madagascar, linked deforestation to the status of protection according to IUCN categories I–VI, used recent deforestation rates to extrapolate forest cover over 2017–2050 and linked the size of forest blocks to the projected persistence of lemur subpopulations. In the six IUCN categories for protected areas in Madagascar the median size of forest blocks is 9–37 km2 and median annual deforestation rates range from 0.02% in the single IUCN category III site to 0.19% in category II and 1.95% in category VI sites. In 2017, 40% of all forest blocks within protected areas were < 10 km2, and this is projected to increase to 45% in 2050. Apart from these small forest fragments, the modal site of forest blocks was 160–320 km2 in 2017, and this is projected to decrease to 80–160 km2 in 2050. The range of > 50% of all lemur species exclusively contains forest blocks of < 10 km2. The modal size of forest blocks > 10 km2 is predicted to remain at 120 km2 until 2050. Although uncertainty remains, these analyses provide hope that forest blocks within the protected areas of Madagascar will remain large enough to maintain lemur subpopulations for most species until 2050. This should allow sufficient time for the implementation of effective conservation measures.
The U.S. Department of Agriculture–Agricultural Research Service (USDA-ARS) has been a leader in weed science research covering topics ranging from the development and use of integrated weed management (IWM) tactics to basic mechanistic studies, including biotic resistance of desirable plant communities and herbicide resistance. ARS weed scientists have worked in agricultural and natural ecosystems, including agronomic and horticultural crops, pastures, forests, wild lands, aquatic habitats, wetlands, and riparian areas. Through strong partnerships with academia, state agencies, private industry, and numerous federal programs, ARS weed scientists have made contributions to discoveries in the newest fields of robotics and genetics, as well as the traditional and fundamental subjects of weed–crop competition and physiology and integration of weed control tactics and practices. Weed science at ARS is often overshadowed by other research topics; thus, few are aware of the long history of ARS weed science and its important contributions. This review is the result of a symposium held at the Weed Science Society of America’s 62nd Annual Meeting in 2022 that included 10 separate presentations in a virtual Weed Science Webinar Series. The overarching themes of management tactics (IWM, biological control, and automation), basic mechanisms (competition, invasive plant genetics, and herbicide resistance), and ecosystem impacts (invasive plant spread, climate change, conservation, and restoration) represent core ARS weed science research that is dynamic and efficacious and has been a significant component of the agency’s national and international efforts. This review highlights current studies and future directions that exemplify the science and collaborative relationships both within and outside ARS. Given the constraints of weeds and invasive plants on all aspects of food, feed, and fiber systems, there is an acknowledged need to face new challenges, including agriculture and natural resources sustainability, economic resilience and reliability, and societal health and well-being.
Protoporphyrinogen oxidase (PPO)-inhibiting herbicides remain an important and useful chemistry 60 yr after their first introduction. In this review, based on topics introduced at the Weed Science Society of America 2021 symposium titled “A History, Overview, and Plan of Action on PPO Inhibiting Herbicides,” we discuss the current state of PPO-inhibiting herbicides. Renewed interest in the PPO-inhibiting herbicides in recent years, due to increased use and increased cases of resistance, has led to refinements in knowledge regarding the mechanism of action of PPO inhibitors. Herein we discuss the importance of the two isoforms of PPO in plants, compile a current knowledge of target-site resistance mechanisms, examine non–target site resistance cases, and review crop selectivity mechanisms. Consistent and reproducible greenhouse screening and target-site mutation assays are necessary to effectively study and compare PPO-inhibitor resistance cases. To this end, we cover best practices in screening to accurately identify resistance ratios and properly interpret common screens for point mutations. The future of effective and sustainable PPO-inhibitor use relies on development of new chemistries that maintain activity on resistant biotypes and the promotion of responsible stewardship of PPO inhibitors both new and old. We present the biorational design of the new PPO inhibitor trifludimoxazin to highlight the future of PPO-inhibitor development and discuss the elements of sustainable weed control programs using PPO inhibitors, as well as how responsible stewardship can be incentivized. The sustained use of PPO inhibitors in future agriculture relies on the effective and timely communication from mode of action and resistance research to agronomists, Extension workers, and farmers.
Infection dynamics in vertebrates are driven by biological and ecological processes. For bats, population structure and reproductive cycles have major effects on RNA virus transmission. On Reunion Island, previous studies have shown that parturition of pregnant females and aggregation of juvenile Reunion free-tailed bats (Mormopterus francoismoutoui) are associated with major increase in the prevalence of bats shedding RNA viruses. The synchronicity of such shedding pulses, however, is yet to be assessed between viruses but also maternity colonies. Based on 3422 fresh faeces collected every 2–5 weeks during four consecutive birthing seasons, we report the prevalence of bats shedding astroviruses (AstVs), coronaviruses (CoVs) and paramyxoviruses (PMVs) in two maternity colonies on Reunion Island. We found that the proportion of bats shedding viruses is highly influenced by sampling collection periods, and therefore by the evolution of the population age structure. We highlight that virus shedding patterns are consistent among years and colonies for CoVs and to a lesser extent for PMVs, but not for AstVs. We also report that 1% of bats harbour co-infections, with two but not three of the viruses, and most co-infections were due to CoVs and PMVs.
Adverse childhood experiences (ACE) can affect educational attainments, but little is known about their impact on educational achievements in people at clinical high risk of psychosis (CHR).
Methods
In total, 344 CHR individuals and 67 healthy controls (HC) were recruited as part of the European Community’s Seventh Framework Programme-funded multicenter study the European Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI). The brief version of the Child Trauma Questionnaire was used to measure ACE, while educational attainments were assessed using a semi-structured interview.
Results
At baseline, compared with HC, the CHR group spent less time in education and had higher rates of ACE, lower rates of employment, and lower estimated intelligence quotient (IQ). Across both groups, the total number of ACE was associated with fewer days in education and lower level of education. Emotional abuse was associated with fewer days in education in HC. Emotional neglect was associated with a lower level of education in CHR, while sexual abuse was associated with a lower level of education in HC. In the CHR group, the total number of ACE, physical abuse, and neglect was significantly associated with unemployment, while emotional neglect was associated with employment.
Conclusions
ACE are strongly associated with developmental outcomes such as educational achievement. Early intervention for psychosis programs should aim at integrating specific interventions to support young CHR people in their educational and vocational recovery. More generally, public health and social interventions focused on the prevention of ACE (or reduce their impact if ACE occur) are recommended.
The conclusion offers new perspectives on how after the crises of the 1930s and the even more horrific Second World War a more durable Atlantic order for the “long” 20th century could be created – an order that was founded as a western system led by the new American superpower and rested on the Marshall Plan, the European Recovery Program and the North Atlantic Treaty Organisation. Reappraising the global significance of these developments, it emphasises that what the principal American and west European decision-makers constructed was not just propelled by the escalating cold war with the Soviet Union but rather, on a deeper level, the outgrowth of longer-term learning processes: attempts to draw deeper lessons not only from the rise of National Socialism, authoritarianism and Stalinism and the Second World War but also from the earlier crises and catastrophes of the “long” 20th century, particularly the First World War and the deficient or unfinished efforts to create a modern international system in its aftermath. Finally, it reflects on the challenges of preserving a functioning and legitimate Atlantic and global order in the early 21st century.
Chapter 22 elucidates how a consolidation of the truncated order of Versailles was first hampered by the divergent longer-term outlooks of the victors and later decisively affected by Wilson’s defeat in the battle over the ratification of the Treaty of Versailles and the Covenant of the League of Nations in the American Senate. It then analyses systematically, and in a global context, how in the aftermath of the American withdrawal from it the crisis of the Versailles system escalated into a full-blown conflict in postwar Europe, which culminated in the transformative Franco-German Ruhr crisis of 1923.
Chapter 11 reappraises the peace conceptions and reordering strategies of Lloyd George and the other architects of the British agenda for the Paris Peace Conference. It argues that what they envisaged centred, not on containing Germany and re-establishing a workable balance of power but rather on the novel aim to create, in cooperation with the United States, a new Atlantic concert that was to stabilise a modern international equilibrium within a recast global order. It illuminates the underlying assumptions and rationales of what became an ambitious British peace programme, which included the most elaborate and influential blueprints for a League of Nations as framework for a novel, and integrative, international concert. And it highlights that British approaches to peacemaking, which were also designed to bolster the British Empire and expand British imperial influence in the Middle East, evolved and changed significantly between the armistice and Versailles as well. Finally, it analyses the extent to which Lloyd George and other key actors like Robert Cecil and Jan Christiaan Smuts had embarked on constructive learning processes – and the extent to which their evolving concepts and strategies were conducive to the creation of a durable and legitimate Atlantic and global order.
Chapter 15 offers new perspectives on the formative struggle to establish the League of Nations as an effective international organisation at the heart of the postwar order. It argues that in spite of the global conceptions they advanced its key architects intended the League to become the superstructure of a new transatlantic international order and security architecture. It analyses how far it was possible to find common ground between the most influential American and British blueprints for an integrative League and the markedly different French plans for an institution of the victors whose main purpose was supposed to be to protect France and constrain Germany. And it illuminates why ultimately the League of Nations came to be founded as a truncated organisation dominated by the principal victors of the Great War and initially excluding the vanquished, which were required to undergo a period of probation to become eligible for membership. Finally, it explains the far-reaching consequences this had and examines how far the League nonetheless had the potential to become the essential framework of a modern Atlantic and global order over time.
Chapter 17 explores how far the new Atlantic order that began to take shape in 1919 could be extended to the most unsettled region after the war: the post-imperial terrain of central and eastern Europe. It reassesses how the victors sought to balance in different ways newly prominent claims of national self-determination and fundamental strategic considerations in their efforts to create a stable system of states in this region – and of how they interacted with the representatives of the numerous east European national causes. While also analysing the Czechoslovakian settlement it then focuses on the victors’ attempts to “solve” the most critical problems in this context, the Polish and the Polish-German questions. And it underscores how extremely difficult it proved to establish a viable Polish nation-state that was not from the outset divided from its more powerful German neighbour by conflicts over contested borders and minority problems. More broadly, it shows how challenging it was to establish effective mechanisms to protect the rights of German, Jewish and other minorities in the new and very heterogeneous east European states. And it elucidates that the western powers’s capacity to forge a durable new order reached distinctive limits in the east.
Chapter 7 offers a newly comprehensive interpretation of the political and ideological war that escalated at the heart of the First World War. It argues that at the core the war turned into a transatlantic struggle not only between war-aim agendas but indeed between competing liberal-progressive, imperialist and Bolshevik visions of peace and future order. It elucidates the unprecedented scope of this struggle by examining not only the aims and conceptions of the different wartime governments and leaders like Wilson, Lloyd George, Ludendorff and Lenin but also the contributions that intellectuals, opinion-makers and other non-governmental actors and associations on both sides of the trenches made to what became the greatest war for “national minds” and “world opinion” in history (up until then). And it brings out the far-reaching consequences this struggle had, both for peacemaking after the war and in the longer term. The analysis emphasises that it catalysed or brought to the fore formative ideas and ideologies of international and domestic-political order for the remainder of the “long” 20th century, including notions of self-determination and universal but hierarchical democratisation, ideas for a modern league of nations and competing blueprints for an internationalist system of communist states.
Chapter 18 analyses how the principal western policy- and decision-makers of 1919 sought to deal with the Bolshevik challenge or, more precisely, the political challenge posed by Lenin’s regime and the political and ideological challenge posed by what they regarded as the threat of a transnational spread of Bolshevism across and beyond Europe. It also reassesses the overall significance of the Bolshevik threat for the making of the nascent Atlantic order after the First World War, underscoring that it affected the peacemaking process but was not as decisive as generations of cold war historians have claimed and highlighting that this process was by no means shaped by a struggle between Wilsonianism and Leninism. It then examines how Lenin, Trotsky and other leading Bolsheviks interpreted the western powers’ pursuits and sought to expand the communist revolution westwards, also through the Communist International. And, finally, it illuminates how difficult it proved for Wilson, Lloyd George, Clemenceau and their advisers to agree on a common approach both towards the Russian civil war and the Bolshevik regime – and how they eventually concentrated on isolating it and preventing a German-Bolshevik alliance, ensuring that subsequently the Soviet Union would remain outside the nascent Atlantic system.
Chapter 14 presents a new interpretation of the peacemaking and reordering process that unfolded at the Paris Peace Conference of 1919. It argues that it was not only the most complex process of its kind in history but also, at the core, a process that was dominated by the struggle to negotiate the underpinnings and ground-rules of a new Atlantic order – which in turn had far-reaching global repercussions. Taking into account the unprecedented multiplicity of governmental and non-governmental actors who tried to influence this process in and beyond Paris it sheds new light on how the peace negotiations ultimately came to be shaped by the interests, concepts and strategies of those who led and represented the most powerful states after the war: Wilson, Lloyd George and Clemenceau – and their main advisers. And it opens up new perspectives on why the first truly modern peacemaking process remained in crucial respects incomplete. It shows that while the principal “peacemakers” began to learn how to forge complex compromises under the challenging conditions of 1919 what they ultimately managed to negotiate could not lay firm and legitimate foundations for a sustainable Atlantic, and global, peace order.
Chapter 4 examines the emergence of different internationalist aspirations on both sides of the Atlantic to supersede conflict-prone imperialist power politics and to advance towards a more pacific international order in the decades before the First World War. It compares the pursuits of liberal and both centrist and more radical socialist actors, non-governmental associations and newly important transnational networks like the burgeoning pacifist movement, the Second International and, notably, the new phalanx of those who demanded that power politics should be replaced by arbitration and authoritative covenants of international law – and who paved the way for the Hague Conventions of 1899 and 1907. It reassesses not only the guiding ideas of the vanguards of such aspirations but also the actual influence they had on transatlantic and global politics in this crucial phase, seeking to offer a systematic explanation of why these counterforces failed to civilise international politics and why ultimately they could not prevent the escalatory processes that caused the catastrophe of 1914.