To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Gene expression studies in psychiatric disorders have proven to be a useful partner to classic genetics approaches, and combined approaches such as convergent functional genomics (CFG) may provide shortcuts to the discovery of genes and overall understanding of the neurobiology involved. The combined approach has been applied with some success to bipolar disorder, alcoholism, and schizophrenia. For complete understanding of the illness, the analyses then need to be pursued at a biological pathway and mechanistic level, integrating environmental effects as key modulators of gene expression and phenotype manifestation. Progress in quantitative profiling of psychiatric phenotypes, and borrowing of concepts and paradigms from other medical fields that are farther along, such as cancer genetics and genomics, are exciting areas of advance for the near future. A (r)evolution in medical nosology in general, and psychiatric nosology in particular, will occur as a result of such studies.