This chapter talks about a 30-year-old man who was referred in 2001 to a neurologist because of memory complaints affecting his ability to perform at work as a cashier in a liquor store. His latest assessment in 01/2010 showed some dysarthria, dragging of his left leg during ambulation, mild face bradykinesia, hyperreflexia of all four limbs, equivocal left plantar response, unsustained clonus of both ankles, and decreased foot tapping bilaterally. There was much hesitation in diagnosing a progressive neurodegenerative condition until 8 years into the symptoms, because of the use of marijuana and the dependant personality. A follow-up is proposed to offer the patient a trial of a cholinesterase inhibitor, considering the finding of a reduced cortical choline-acetyl-transferase (CAT) activity in his mother's autopsy. The objective findings on neuro-imaging allow him to obtain full medical disability for a well-defined neurological condition.