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This chapter conveys that a 65-year-old technical worker with previous management function had been unable to work because of pulmonary problems for 7 years. This highly educated man had been diagnosed with extrinsic allergic alveolitis 7 years ago. A diagnosis of subjective memory complaints (SMC) was made. The fact that cerebrospinal fluid (CSF) values were abnormal was not taken into account at that time because of lack of a clinical diagnosis of dementia. Referral to a psychiatrist was advised for evaluation of a possible mood disorder and for counseling on how to deal with his behavioral disturbances. SMC or subjective cognitive impairment (SCI) in the absence of mild cognitive impairment (MCI) or dementia is more and more accepted as a separate clinical entity. Depression, anxiety, disturbed sleep, fatigue, and loss of energy were responsible for a conversion from SCI to MCI, but subsequently reverted back to SCI after follow-up.