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Algorithmic graph theory has been expanding at an extremely rapid rate since the middle of the twentieth century, in parallel with the growth of computer science and the accompanying utilization of computers, where efficient algorithms have been a prime goal. This book presents material on developments on graph algorithms and related concepts that will be of value to both mathematicians and computer scientists, at a level suitable for graduate students, researchers and instructors. The fifteen expository chapters, written by acknowledged international experts on their subjects, focus on the application of algorithms to solve particular problems. All chapters were carefully edited to enhance readability and standardize the chapter structure as well as the terminology and notation. The editors provide basic background material in graph theory, and a chapter written by the book's Academic Consultant, Martin Charles Golumbic (University of Haifa, Israel), provides background material on algorithms as connected with graph theory.
This is an epidemiological study of carbapenem-resistant Enterobacteriaceae (CRE) in Veterans’ Affairs medical centers (VAMCs). In 2017, almost 75% of VAMCs had at least 1 CRE case. We observed substantial geographic variability, with more cases in urban, complex facilities. This supports the benefit of tailoring infection control strategies to facility characteristics.
Although infections caused by Acinetobacter baumannii are often healthcare-acquired, difficult to treat, and associated with high mortality, epidemiologic data for this organism are limited. We describe the epidemiology, clinical characteristics, and outcomes for patients with extensively drug-resistant Acinetobacter baumannii (XDRAB).
Retrospective cohort study
Department of Veterans’ Affairs Medical Centers (VAMCs)
Patients with XDRAB cultures (defined as nonsusceptible to at least 1 agent in all but 2 or fewer classes) at VAMCs between 2012 and 2018.
Microbiology and clinical data was extracted from national VA datasets. We used descriptive statistics to summarize patient characteristics and outcomes and bivariate analyses to compare outcomes by culture source.
Among 11,546 patients with 15,364 A. baumannii cultures, 408 (3.5%) patients had 667 (4.3%) XDRAB cultures. Patients with XDRAB were older (mean age, 68 years; SD, 12.2) with median Charlson index 3 (interquartile range, 1–5). Respiratory specimens (n = 244, 36.6%) and urine samples (n = 187, 28%) were the most frequent sources; the greatest proportion of patients were from the South (n = 162, 39.7%). Most patients had had antibiotic exposures (n = 362, 88.7%) and hospital or long-term care admissions (n = 331, 81%) in the prior 90 days. Polymyxins, tigecycline, and minocycline demonstrated the highest susceptibility. Also, 30-day mortality (n = 96, 23.5%) and 1-year mortality (n = 199, 48.8%) were high, with significantly higher mortality in patients with blood cultures.
The proportion of Acinetobacter baumannii in the VA that was XDR was low, but treatment options are extremely limited and clinical outcomes were poor. Prevention of healthcare-associated XDRAB infection should remain a priority, and novel antibiotics for XDRAB treatment are urgently needed.
This chapter reviews the spread of irrigation technology across the Sahara in antiquity, and its effects on settlement agriculture and the movement of people. Recent work has stressed the close connections between the introduction of foggara technology and the rise of Garamantian civilisation, which featured intensive agriculture and incipient urbanism. However, many oases achieved substantial size through the use of well technologies, artesian springs or a combination of technologies. Another key question relates to the effects of the eventual decline and failure of these irrigation systems in terms of population movement and fragmentation of states such as the Garamantes. After presenting new AMS dating evidence for Garamantian foggaras, the chapter advances the discussion by examining the wider picture of foggara distribution within a survey of the evidence of irrigation technologies across the Sahara and whether and to what extent the distribution of foggaras beyond the core Garamantian heartlands might be seen as an indication of Garamantian control or influence. It explores what foggaras, wells and new crop introductions might suggest about agricultural intensification and organisation. This has implications for assessing agricultural intensification in the ancient Sahara. Finally, it considers causes and possible effects of irrigation failure and in some cases collapse.
Formation of close double white dwarfs likely requires the initial binary system to evolve through two successive common envelope (CE) phases. A prominent method for describing CE outcomes involves defining an ejection efficiency, αeff, which quantifies the fraction of orbital energy available to unbind the envelope. Reproducing observed post-CE orbital parameters has proven difficult for numerical simulations, as the companion’s decaying orbit fails to eject the envelope. The ejection failure seen in numerical simulations may be resolved with a proper treatment of convection, whereby the binary orbit shrinks before energy can drive ejection. Where the orbital decay timescale exceeds the convective transport timescale, the energy released during inspiral is carried to the stellar surface and radiated away. By including convection, we produce sub-day post-CE orbital periods, a result consistent with observations. We comment on the effects of convection for the population of double white dwarfs that evolve through two CEs.
Carbonate glasses can be formed routinely in the system K2CO3–MgCO3. The enthalpy of formation for one such 0.55K2CO3–0.45MgCO3 glass was determined at 298 K to be 115.00 ± 1.21 kJ/mol by drop solution calorimetry in molten sodium molybdate (3Na2O·MoO3) at 975 K. The corresponding heat of formation from oxides at 298 K was −261.12 ± 3.02 kJ/mol. This ternary glass is shown to be slightly metastable with respect to binary crystalline components (K2CO3 and MgCO3) and may be further stabilized by entropy terms arising from cation disorder and carbonate group distortions. This high degree of disorder is confirmed by 13C MAS NMR measurement of the average chemical shift tensor values, which show asymmetry of the carbonate anion to be significantly larger than previously reported values. Molecular dynamics simulations show that the structure of this carbonate glass reflects the strong interaction between the oxygen atoms in distorted carbonate anions and potassium cations.
Geosequestration involves the deep geological storage of carbon dioxide from major industrial sources, providing a potential solution for reducing the rate of increase of atmospheric concentrations of carbon dioxide and mitigating climate change. This volume provides an overview of the major geophysical techniques and analysis methods for monitoring the movement and predictability of carbon dioxide plumes underground. Comprising chapters from eminent researchers, the book is illustrated with practical examples and case studies of active projects and government initiatives, and discusses their successes and remaining challenges. A key case study from Norway demonstrates how governments and other stake-holders could estimate storage capacity and design storage projects that meet the requirements of regulatory authorities. Presenting reasons for embracing geosequestration, technical best practice for carbon management, and outlooks for the future, this volume provides a key reference for academic researchers, industry practitioners and graduate students looking to gain insight into subsurface carbon management.