Greenhouse studies were conducted to determine the response of purple and yellow nutsedge to selective placement of 5 cm of soil treated with AC 263,222 above and/or below nutsedge tubers. AC 263,222 applied early POST (EPOST) or POST at 71 g ai ha-1 as a foliar, soil, or foliar + soil application also was evaluated. AC 263,222 applied below nutsedge tubers did not reduce purple or yellow nutsedge shoot number, shoot dry weight, shoot regrowth dry weight, or root-tuber dry weight. However, when it was applied above purple nutsedge tubers, shoot dry weight was reduced; and when it was applied above yellow nutsedge tubers, shoot dry weight and root dry weight were reduced. AC 263,222 applied 5 cm above + 5 cm below purple nutsedge tubers reduced shoot number, shoot dry weight, shoot regrowth dry weight, and root dry weight to 9, 4, 10, and 16% of the control, respectively, in purple nutsedge and to 23, 16, 9, and 15% of the control, respectively, in yellow nutsedge. AC 263,222 applied EPOST or POST reduced shoot dry weight, shoot regrowth dry weight, and root dry weight of purple nutsedge to less than or equal to 11, 7, and 27% of the control, respectively, and to less than or equal to 10, 16, and 29% of the control, respectively, for yellow nutsedge with no differences between application methods. The foliar and soil activity of AC 263,222 for purple and yellow nutsedge control provides an advantage over currently registered peanut herbicides.