We are developing modular arrays of CdZnTe radiation detectors for high-resolution nuclear medicine imaging. Each detector is delineated into a 64×64 array of pixels; the pixel pitch is 380 jim. Each pixel is connected to a corresponding pad on a multiplexer readout circuit. The imaging system is controlled by a personal computer. We obtained images of standard nuclear medicine phantoms in which the spatial resolution of approximately 1.5 mm was limited by the collimator that was used. Significant improvements in spatial resolution should be possible with different collimator designs. These results are promising for high-resolution nuclear medicine imaging.