Prospective, randomized, two-arm, parallel assignment. 150 individuals diagnosed with major depression disorder (MDD) according to DSM-IV-TR criteria, taking combined therapy in doses considered appropriate for at least 9 months, without showing clinical remission, defined as having an HAMD17 total score ≤ 7, attending the out-patient psychiatry clinic, were initially screened through an interview with a psychiatrist. Those meeting study criteria were randomized to one of two groups: control and aerobic exercise. The study protocol was approved by the Institutional Review Board. All participants provided written informed consent. Study protocol Exercise group: individuals were assigned moderate intensity exercise, in addition to their usual pharmacological therapy. Control group: individuals who were not assigned any exercise and remained taking their usual pharmacological therapy. Both groups maintained the pharmacological therapy unchanged during the 12 week study period. All participants were evaluated at baseline (time 0: before starting the physical activity program), and at 4, 8 and 12 weeks for depressive symptoms, functional assessment and Quality of Life.

Dirofilariosis caused by Dirofilaria immitis (heartworm) is a zoonosis, considered an endemic disease of dogs and cats in several countries of Western Europe, including Portugal. This study assesses the levels of D. immitis exposure in humans from Northern Portugal, to which end, 668 inhabitants of several districts belonging to two different climate areas (Csa: Bragança, Vila Real and Csb: Aveiro, Braga, Porto, Viseu) were tested for anti-D. immitis and anti-Wolbachia surface proteins (WSP) antibodies. The overall prevalence of seropositivity to both anti-D. immitis and WSP antibodies was 6.1%, which demonstrated the risk of infection with D. immitis in humans living in Northern Portugal. This study, carried out in a Western European country, contributes to the characterisation of the risk of infection with D. immitis among human population in this region of the continent. From a One Health point of view, the results of the current work also support the close relationship between dogs and people as a risk factor for human infection

In Central America, population and food demands are rising rapidly, while yields of staple crops, maize and beans, remain low. To identify the main factors limiting production, field trials were established in six maize- and bean-producing regions in Guatemala, Honduras and El Salvador, representing about three-quarters of the maize-producing area. Potential yield-limiting factors were evaluated in 2017 and included: water stress, nutrient deficiency, pest and disease pressure, and/or inter-plant competition. When considering all sites, improved fertilization and pest and disease control significantly improved yields in maize by 11 and 16%, respectively but did not have a significant effect in beans. Irrigation had no effect due to good rainfall distribution over the growing season. Optimized planting arrangement resulted in an average 18% increase in maize yield, making it the most promising factor evaluated. The treatment and site combinations that increased both crop productivity and net profit included management changes that improved resource use efficiency. However, the contribution of each limiting factor to yield gaps varied across sites and no treatment was effective at increasing yield consistently across sites. Production constraints are highly dependent on local management practices and agroecological location. Therefore, public and private development efforts that seek to increase production should conduct multi-year, participatory experiments to identify limitations pertinent to the area in question. The next step is then to evaluate sustainable and profitable practices, to address those limitations and provide sound recommendations to farmers while decreasing the environmental and economic costs.

Heavy weight gilts commonly show signs of oestrus during the late finishing phase, which results in a period of reduced feed intake and growth rate. Immunization against gonadotropin-releasing hormone (GnRH) (IM, immunocastration) was developed for finishing boars and recently extrapolated to females. Immunocastration acts by suppressing reproductive activity and improving the growth potential. The objective of this study was to evaluate the effects of IM on growth performance, reproductive activity and carcass characteristics of late finishing gilts. Seventy-two gilts (63.49 ± 0.39 kg) were either injected with saline (Intact) or immunized against GnRH (Immunized). The study consisted of three experimental periods: between the first to second immunization (V1 to V2, 15 to 19 weeks of age), from the second immunization to the beginning of daily boar exposure (DBE) (V2 to DBE, 19 to 21 weeks of age) and from the beginning of DBE to slaughter (S) (DBE to S, 21 to 25 weeks of age). Immunized gilts showed an overall increase (from 15 to 25 weeks) of 3.90 kg (P < 0.05) of live weight, 56 g (P < 0.05) of average daily gain (ADG) and 250 g (P < 0.001) of average daily feed intake (ADFI). Immunized gilts had a greater ADFI (+240 g, P < 0.05) and worse feed conversion ratio (+0.26, P < 0.05) from 19 (V2) to 21 weeks of age (before DBE). Furthermore, those females had higher feed intake (+410 g; P < 0.001) plus greater daily weight gain (+92 g; P < 0.05) from V2 to S, and from DBE to S (+470 g of ADFI, P < 0.001; +129 g of ADG, P < 0.01, respectively). Immunocastration had no effect on backfat thickness, lean meat percentage and weight, cold carcass yield or loin depth (P > 0.05). Immunized gilts showed 4.4% increased cold carcass weight (P < 0.01) and 10.6% greater gross flank weight (P < 0.001). Immunization against GnRH did not influence shoulder, collar, loin, belly or ham weights. Nor did it influence belly fat thickness, or meat, skin plus fat and bones yields of cold ham (P > 0.05). Immunocastration reduced ovarian and uterine weights by 82% (P < 0.001) and 93% (P < 0.001), respectively, and suppressed oestrus manifestation in all gilts in the immunized group (P < 0.001). These results indicate that immunization against GnRH is a promising tool for stimulating growth performance with no detrimental effects on carcass quality of heavy weight finishing gilts, by means of oestrus suppression.

Smallholder livestock systems in Central America are typically based on pastures with traditional grasses and associated management practices, such as pasture burning and extensive grazing. With the rise of the global population and a corresponding increase in demand for meat and milk production, research efforts have focused on the development of improved grasses and the incorporation of legume species that can increase productivity and sustainability of Central American livestock systems. However, farmer adoption remains very limited, in part due to the lack of site-specific evaluation and recommendations by local institutions. Using a multi-site participatory approach, this study examined the potential of five improved grasses and five species of forage legumes as alternatives to the broadly disseminated grass Hyparrhenia rufa (cv. Jaragua) in pasture-based cattle systems in western Honduras and northern El Salvador. Improved grasses (four Brachiaria sp. and Megathyrsus maximus) produced significantly more biomass than H. rufa; also four of the five legume varieties evaluated (Canavalia ensiformis, Canavalia brasiliensis, Vigna unguiculata, and Vigna radiata) demonstrated high adaptability to diverse environmental conditions across sites. Farmer participatory evaluation offers a valuable means to assess performance of forages and will likely contribute to their improved utilization. Future research is needed on more refined management recommendations, pasture system design, costs and environmental benefits associated with the adoption of these forages in local livestock production systems.

Knowledge of tissue and cuts growth depending on the sex could be used to improve performance and efficiency. Computed tomography (CT) is a non-invasive technology that enables the study of the body composition of live animals during growth. The aims of the present study were (1) to evaluate variation in the body composition of four sex types (SEX) of pigs (castrated males (CM), immunocastrated males (IM), entire males (EM) and females (FE)) at the live weight of 30, 70, 100 and 120 kg, assessed using CT; (2) to model the growth of the main tissues and cuts; and (3) to predict the mature BW (MBW) of the four SEX and establish the relationships between the growth models and the MBW. There were significant phenotypic differences in the allometric growth of fat and lean among SEX. For the lean tissue, FE and EM showed higher values of the b coefficient than CM and IM (1.07 and 1.07 v. 1.00 and 1.02, respectively) all of them close to unity, indicating a proportional growth rate similar to live weight and that this tissue developed faster in FE and EM than in CM and IM. However, these differences were not related to differences in estimated MBW. There were significant differences in estimated MBW among SEX, being higher in IM and EM than in CM and FE (303 and 247 v. 219 and 216 kg), however, the MBW may have been overestimated, especially for the IM. The poorer accuracy of the MBW estimate for the IM could be due to a maximum live weight of 120 kg in the experiment, or to the fact that this particular SEX presented two clear behaviours, being more similar to EM from birth to the second injection of the vaccine (130 days) and comparable with CM from that point to the final BW.

We have combined observations of the Antennae galaxies from the radio interferometer ALMA and from the optical interferometer GHαFaS (Galaxy Hα Fabry-Perot System). The two sets of observations have comparable angular and spectral resolutions, enabling us to identify 142 giant molecular clouds (GMCs) and 303 Hii regions. We have measured, and compared, their basic physical properties (radius, velocity dispersion, luminosity). We study the mass functions of Hii regions and GMCs, where a double population of Hii regions due to a double population of GMCs is found. Using the velocity dispersion measurements, we claim that the difference between the regimes is the nature of the dominant binding force. For the regions in the lower mass range, the dominant force is the external pressure, while in the higher mass range it is the internal gravity of the clouds. We have applied the same method to similar observations (GHαFaS & ALMA) of Arp 236 and NGC 1614 finding similar results.

We have observed 3 pairs of interacting galaxies (the Antennae, Arp 236, and NGC 1614) using the Fabry-Perot interferometer GHαFaS (Galaxy Hα Fabry-Perot system) on the 4.2m William Herschel Telescope (WHT) at the Observatorio del Roque de los Muchachos, La Palma. We have extracted the physical properties (sizes, Hα luminosity and velocity dispersion) of Hii regions. We have combined also these observations with ALMA archival observations of these interacting galaxies, finding that there is a set of brighter and denser star forming regions. We have been able to compare these properties with those of two SMGs at redshift ~ 2.

Los Alamos National Laboratory has calculated a new generation of radiative opacities (OPLIB data using the ATOMIC code) for elements with atomic number Z = 1-30 with improved physics input, updated atomic data, and finer temperature grid to replace the Los Alamos LEDCOP opacities released in the year 2000. We calculate the evolution of standard solar models including these new opacities, and compare with models evolved using the Lawrence Livermore National Laboratory OPAL opacities (Iglesias & Rogers 1996). We use the solar abundance mixture of Asplund et al. 2009. The Los Alamos ATOMIC opacities (Colgan et al. 2013a, 2013b, 2015) have steeper opacity derivatives than those of OPAL for temperatures and densities of the solar interior radiative zone. We compare the calculated nonadiabatic solar oscillation frequencies and solar interior sound speed to observed frequencies and helioseismic inferences. The calculated sound-speed profiles are similar for models evolved using either the updated Iben evolution code (see Guzik & Mussack 2010), or the MESA evolution code (Paxton et al. 2015). The LANL ATOMIC opacities partially mitigate the ‘solar abundance problem’.

We present a new method for the detection and characterization of large scale expansion in galaxy discs based on Hα Fabry-Perot spectroscopy, taking advantage of the high spatial and velocity resolution of our instrument (GHαFaS). The method analyses multi-peaked emission line profiles to find expansion along the line of sight on a pixel-by-pixel basis. At this stage we have centred our attention on the large scale structures of expansive gas which show a coherent gradient of velocities from their centres as a result of both bubble shape and projection effect. The results show a wide range of expansion velocities in these superbubbles, ranging from 30-150 km/s, with the expected trend of finding the higher velocities in the more violent areas of the galaxies. We have applied the technique to the Antennae and M83, obtaining spectacular results, and used these to investigate to what extent kinematically derived ages can be found and used to characterize the ages of their massive star clusters.