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Although in vitro fertilization (IVF) was developed for the treatment of tubal infertility, , it soon became apparent that human IVF had many other applications such as male factor subfertility , unexplained subfertility  and restoring fertility in women without functioning ovaries using ovum  or embryo donation. Although ovum donation was originally used to treat women with Turner’s syndrome , it has also been successfully applied to women with other causes of premature ovarian insufficiency (POI) over the last 35 years. The concept of gamete donation is not new, with sperm donation (DI) having been utilized, initially with fresh sperm and subsequently with stored frozen sperm for several decades . In DI the woman’s partner becomes the social father but is not the genetic father, whereas in oocyte donation the woman who has the child is the birth and social mother, but not the genetic mother. Although the child is not directly genetically linked, egg donation allows the patient to carry and deliver her husband’s genetic child.
In order to maximize the chance of IVF success, couples need to ensure that their preconceptual health is optimal to increase the quality of gametes and reproductive fitness. This text reviews the medical and lifestyle factors that can affect the body at preconception stage, such as micronutrients, stress, hormonal and gynecologic assessment, as well as environmental factors such as optimal weight and age for childbirth. This book will enable all medical practitioners and healthcare professionals to give evidence-based advice to influence the success rate of subsequent IVF cycles, and ensure that every child is born in the best possible condition. Part of a four-book series on optimizing different aspects of the IVF cycle, this book focusses on preparing the body for assisted conception. Other books in the series focus on the egg and embryo, the endometrium, and the sperm.
Since the Women's Health Initiative report of 2002, there has been reluctance to provide women with hormone replacement therapy due to a lack of clarity about the potential risks. This book reviews all aspects of the menopause and places the benefits and risks of hormone therapy into perspective. It fully informs the reader regarding the evidence base of all aspects of menopause medicine and can be used either as a reference book to solve specific problems, or as a book to be read cover-to-cover. It will provide the reader with the latest information and as a result encourage confidence in managing menopause related problems. This practical, evidence-based guide is suitable for all health professionals managing the menopause including gynaecologists, sexual and reproductive medicine specialists, general practitioners and trainees in any of the above specialties.