Cotton (Gossypium hirsutum L. ‘Westburn M’) was grown for 2 yr at two locations with full-season interference from buffalobur (Solanum rostratum Dunal ♯ SOLCU) at densities ranging from 0 to 64 plants/10 m of row. Dry weight of buffalobur harvested increased by 0.063 to 0.303 kg/plot for each additional weed/10 m of row. Intraspecific competition among buffalobur plants was observed at the higher weed densities. Cotton plant height was reduced by 16 and 32 buffalobur plants/10 m of row (or more) at Tipton and Perkins, OK, respectively, when compared with cotton grown under weed-free conditions. The threshold densities at which initial lint yield reductions occurred were 8 buffalobur plants/10 m of row in 1982 and 1983 at Tipton and 32 and 2 plants/10 m of row at Perkins in 1982 and 1983, respectively. Lint yields were reduced curvilinearly from 6 to 18 kg/ha for each additional buffalobur plant/10 m of row. Fiber quality was not significantly influenced by weed density when analyzed over all experiments; however, 50% span length, uniformity index, and micronaire were adversely affected in some environments.