The three-dimensional resonant interaction of a plane Tollmien-Schlichting wave, having a frequency f1, with a pair of oblique waves having frequencies ½ f1, was observed and studied experimentally. In the initial stages, the interaction proved to be a parametric resonance, resulting in the amplification of small random priming (background) oscillations of frequency ½ f1, and of a packet of low-frequency oscillations. The resonant interaction of waves in a boundary layer was investigated also by introducing a priming oscillation with frequency f’ = ½ f1 + Δf for different values of the frequency detuning Δf. The importance of the discovered wave interaction in boundary-layer transition is demonstrated. Causes of realization of different types of laminar-flow breakdown are discussed.