The indigenous poultry germplasm of Andaman & Nicobar Islands includes Nicobari fowl, Barred desi, Naked neck and Frizzle fowl, of which Nicobari fowl is the only native fowl of these Islands. The study of immune status is indirectly correlated with the disease resistance characteristics of the bird’s. The present study was conducted to know the primary humoral antibody response to Sheep RBC (SRBC) and their persistence in the immune system. However, for complete immunocompetence status, beside humoral responses the CMI and phagocytic responses are also to be considered.