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To determine changes in incidence of reactivation of Toxoplasma gondii infection, manifesting as toxoplasmic encephalitis, and to assess the immunological mechanisms controlling reactivation in HIV-infected patients, a Czech cohort of 502 HIV/T. gondii co-infected patients was followed for 2909·3 person-years. The incidence of toxoplasmic encephalitis between the periods before and after the introduction of combination antiretroviral therapy (cART) was compared. Toxoplasmic encephalitis was diagnosed in 21 patients. In those patients the geometric mean value of CD4+ T lymphocytes was 12·6 times lower than in patients with non-reactivated T. gondii infection but an additionally significant decline in CD8+ T lymphocytes (3·3-fold) and natural killer cells (4·3-fold) was observed. This confirms the significance of these parameters. A twelvefold decrease in Toxoplasma reactivation incidence (40·2 vs. 3·4/1000 person-years) between monitored periods was seen. In the cART era, Toxoplasma reactivation was observed only in patients with unrecognized HIV infection or refusing therapy.
This volume of new essays by leading scholars treats a representative sampling of German realist prose from the period 1848 to 1900, the period of its dominance of the German literary landscape. It includes essays on familiar, canonical authors -- Stifter, Freytag, Raabe, Fontane, Thomas Mann -- and canonical texts, but also considers writers frequently omitted from traditional literary histories, such as Luise Mühlbach, Friedrich Spielhagen, Louise von François, Karl May, and Eugenie Marlitt. The introduction situates German realism in the context of both German literary history and of developments in other European literatures, and surveys the most prominent critical studies of ninteenth-century realism. The essays treat the following topics: Stifter's Brigitta and the lesson of realism; Mühlbach, Ranke, and the truth of historical fiction; regional histories as national history in Freytag's Die Ahnen; gender and nation in Louise von François's historical fiction; theory, reputation, and the career of Friedrich Spielhagen; Wilhelm Raabe and the German colonial experience; the poetics of work in Freytag, Stifter, and Raabe; Jewish identity in Berthold Auerbach's novels; Eugenie Marlitt's narratives of virtuous desire; the appeal of Karl May in the Wilhelmine Empire; Thomas Mann's portrayal of male-male desire in his early short fiction; and Fontane's Effi Briest and the end of realism. Contributors: Robert C. Holub, Brent O. Petersen, Lynne Tatlock, Thomas C. Fox, Jeffrey L. Sammons, John Pizer, Hans J. Rindisbacher, Irene S. Di Maio, Kirsten Belgum, Nina Berman, Robert Tobin, Russell A. Berman. Todd Kontje is professor of German at the University of California, San Diego.
This volume brings together some of the leading scholars of German realism working today and testifies to the vitality of the field. It includes essays on familiar authors — Stifter, Freytag, Raabe, Fontane, Thomas Mann — and canonical texts but also considers writers frequently omitted from traditional literary histories, including Luise Mühlbach, Friedrich Spielhagen, Louise von François, Karl May, and Eugenie Marlitt. Although the book does not attempt to cover every author or aspect of the period — which would, in any case, be impossible — an effort has been made to include a representative sampling of German realist prose in the second half of the nineteenth century. While the contributors vary in their choice of topic and approach, they all situate the literary works in their historical context and also suggest reasons why these texts remain of interest today. Thus, the contributors focus on questions of national identity during the period of Germany's first political unification; examine representations of Germans abroad and foreigners at home at a time of mass emigration and colonial expansion; consider attitudes toward work in a period of rapid industrialization; and reflect on questions of sexual identity and gender roles in works by both men and women in the era of the family journal, the first organized women's movements, and the earliest advocates for homosexual rights. Each essay refers to relevant literature on the particular author or topic discussed, and the volume concludes with a complete list of works cited. The book should, therefore, be of interest primarily to students and scholars of German literature but also to those concerned with the topic of realism in literature and questions of subject-formation, national identity, and cultural memory in an era of rapid historical change.
I would like to thank the contributors for their willingness to collaborate on this project, their patience with my demands, their respect for deadlines, and, above all, the quality of their work.