Cameraria macrocarpae Freeman is a univoltine blotch miner which feeds on the palisade parenchyma of bur oak leaves. The larvae have two morphologically distinct forms and seven instars. It overwinters in the sixth instar, inside the mined leaf. Females deposit their eggs in rows, usually beside the mid-rib, and the larvae enter the leaf directly under the chorion. The larvae from each egg cluster form a common mine on the upper surface of the leaf. The mines of C. macrocarpae are brownish and each contains several larvae, differing from the whitish mines of Cameraria hamadryadella (Clemens), each containing a single larva. Nine species of parasites are listed.