Infants who require intensive care are at considerable risk of death or long-term neurodevelopmental disability. Therefore, noninvasive methods have been sought for assessing the structure and function of the brain in the immediate newborn period. The major aims are to investigate the prevalence and mechanisms of brain-damaging lesions, to test preventive strategies and treatment, and to assign the prognosis of the infants. Several methods have proved their worth, e.g., ultrasound imaging, electroencephalography, including the testing of evoked potentials, and Doppler ultrasonography for measuring flow velocity in intracerebral vessels.