The remarkable progress in additive manufacturing has promoted the design of architected materials with mechanical properties that go beyond those of conventional solids. Their realization, however, leads to architectures with process-induced defects that can jeopardize mechanical and functional performance. In this work, we investigate experimentally and numerically as-manufactured defects in Ti–6Al–4V octet truss lattice materials fabricated with selective laser melting. Four sets of as-manufactured defects, including surface, microstructural, morphological, and material property imperfections, are characterized experimentally at given locations and orientations. Within the characterized defects, material property and morphological defects are quantified statistically using a combination of atomic force microscopy and micro–computed tomography to generate representative models that incorporate individual defects and their combination. The models are used to assess the sensitivity to as-manufactured defects. Then, the study is expanded by tuning defects amplitude to elucidate the role of the magnitude of as-designed defects on the mechanical properties of the lattice material.