Ultrasonic additive manufacturing (UAM) is a solid state manufacturing process that combines additive joining of thin metal tapes and subtractive computer numerical control milling operations to generate near-net shape metallic parts. We conducted a design of experiments study with the goal to optimize UAM process parameters for aluminum 6061. Weld force, weld speed, amplitude, and temperature were varied based on a Taguchi L18 experimental design matrix and tested for mechanical strength using a shear test and a comparative push-pin test. Statistical methods including analysis of variance (ANOVA), mean effects plots, and interaction effects plots were conducted to determine optimal process parameters. Results indicate that weld amplitudes of 32.76 µm and weld speeds of 84.6 mm/s yield maximum mechanical strength while temperature and force are statistically insignificant for the parameter levels tested. Annealing of cold-worked foil stock produces a 13% strength increase for UAM samples over homogeneous annealed material.