The aim of the present research is to evaluate changes in the glacierized area, glacier-water resources and glacial run-off during the last 25–30 years. The prevailing process of degradation has resulted in a 16% diminution of the glacierized area in Gissaro-Alai and 11% in the Pamirs. The ratio between the advancing, stationary and retreating glaciers in the Gissaro-Alai mountains is 1:5:17, and the one in the Pamirs is 1:1:4. Moraine-covering of the glaciers has increased from 8 to 11 % in the Gissaro-Alai and from 6 to 11 % in the Pamirs. Ice-volume diminution of glaciers in the Gissaro-Alai is 17% and in the Pamirs it is 12%. The mean long-term annual volume of total glacial melting, glacial run-off and variation coefficients of these values in the river basins of the Pamirs and the Gissaro-Alai are described as functions of the altitudes of glacier termini, equilibrium lines and a new parameter, which characterizes the influence of the glacierized area distribution according to altitude on run-off. The data presented here indicate changes in mean annual volumes of glacier water yield in the river basins of the Pamirs and the Gissaro-Alai mountains, related to glaciation evolution in 1957–80.