In vitro, antibiotic effects of the culture filtrates
of 29 species of aquatic hyphomycetes against Gram-negative and Gram-positive
bacteria, yeasts and hyphomycetes were studied. The culture filtrates of
38% of isolates were active in at least one of our tests for
biological activity. Fifteen species inhibited growth of bacteria and four
demonstrated antifungal activity. Filtrates of 35% of the
isolates were antibacterial. About 50% of the isolates, those with the
largest in vitro inhibitory activities (Dimorphosphora foliicola,
Flagellospora sp. and Mycocentrospora sp.) were obtained
from wood. Filtrates of Articulospora tetracladia were not only
active against
Gram −ve bacteria, but were also antiviral against bacteriophage
T4 and influenza virus.