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Borderline personality disorder and cognition: unraveling the enigma one piece at a time!

Published online by Cambridge University Press:  15 May 2023

Sujita K. Kar*
Affiliation:
Department of Psychiatry, King George’s Medical University, Lucknow, India
Saalya Chak
Affiliation:
Department of Psychiatry, King George’s Medical University, Lucknow, India
*
Corresponding author: Sujita K. Kar; Email: drsujita@gmail.com
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Abstract

Type
Letter to the Editor
Copyright
© The Author(s), 2023. Published by Cambridge University Press

Dear Editor,

Aslan et alReference Aslan, Grant and Chamberlain 1 conducted a study on patients with borderline personality disorder that investigated cognition, impulsivity, and the correlation of these parameters with symptom severity of borderline personality disorder. The authors also compared these parameters with matched healthy controls. The selection criteria are carefully chosen for the enrolment of the participants in this study. The study interestingly reported a significant positive association between borderline personality disorder symptom severity and impulsivity. Also, the cognitive flexibility of patients with borderline personality disorder is significantly compromised than the healthy controls; however, no association between borderline symptom severity and cognitive functions was measured.Reference Aslan, Grant and Chamberlain 1

Earlier evidence suggests significant impairment of social cognition and neurocognition in patients with borderline personality disorder, significantly impairing their real word functioning.Reference Monarch, Saykin and Flashman 2 , Reference Zegarra-Valdivia and Chino Vilca 3 The severity of the psychopathology of borderline personality disorder is associated with the extent of neurocognitive impairment.Reference Monarch, Saykin and Flashman 2 Researchers explained the possibility of cognitive deficits as endophenotype markers in borderline personality disorder as the cognitive deficits are closely related to the clinical symptoms of borderline personality disorder.Reference Zegarra-Valdivia and Chino Vilca 3 Due to the significance of cognitive errors in borderline personality disorder, the psychotherapeutic interventions focus on the correction of cognitive errors and schemas in these patients.

The study of Aslan et alReference Aslan, Grant and Chamberlain 1 has not ruled out psychiatric comorbidities like other personality disorders, depression, and anxiety disorders in their study, which can be a major confounder in this study. Though the authors have acknowledged their limitations, it is known that these psychiatric conditions can significantly affect cognition and impulsivity as well as can mask the symptom severity of borderline personality disorder. Future research should consider measuring cognition in borderline personality disorder, excluding these psychiatric comorbidities. Similarly, several medical conditions like migraine, epilepsy, and other neurological conditions (even if they are stable) may have an effect on cognition and impulsivity, which also need to be considered in such research. Treatment of medical conditions (eg, antiepileptics for epilepsy; topiramate and valproate for migraine) can also change impulsivity and affect cognitive function.Reference Eddy, Rickards and Cavanna 4 Interestingly, no association was found between the severity of borderline personality disorder and cognitive functioning, though there was a significant positive association between the severity of borderline symptoms and impulsivity. It is well known that impulsivity is related to the failure of the response inhibition process (a critical executive function).Reference Bari and Robbins 5 As the symptom severity of borderline personality is increasing the impulsivity, the cognitive function should decline linearly in a significant manner. However, the absence of such findings can be attributed to the small sample size (n = 26) and the possibility of the interplay of multiple other noncognitive factors involved in impulsivity and borderline symptom severity. Also, the presence of comorbid conditions might act as confounders to alter the association between cognitive function and borderline symptom severity. Most of the existing research that evaluated cognitive functioning among patients with borderline personality disorder is limited by a small sample size and measurement of cognitive function as a cross-sectional measure. Longitudinal studies on a larger sample size addressing all possible confounding factors may give better insight into the association of cognitive function with symptoms of borderline personality disorder

Author contribution

Conceptualization: S.K.K.; Literature search: S.K.K., S.C.; Manuscript writing and editing: S.K.K., S.C.

Disclosure

The authors declare none.

References

Aslan, IH, Grant, JE, Chamberlain, SR. Cognition in adults with borderline personality disorder. CNS Spectr. 2023 Mar 16:16. doi:10.1017/S1092852923001177. Epub ahead of print. PMID: 36924168CrossRefGoogle Scholar
Monarch, ES, Saykin, AJ, Flashman, LA. Neuropsychological impairment in borderline personality disorder. Psychiatr Clin North Am. 2004;27(1):6782, viii–ix. doi:10.1016/S0193-953X(03)00109-6.CrossRefGoogle ScholarPubMed
Zegarra-Valdivia, JA, Chino Vilca, BN. Social cognition and executive function in borderline personality disorder: evidence of altered cognitive processes. Salud Ment. 2019;42:3342. doi:10.17711/SM.0185-3325.2019.005.CrossRefGoogle Scholar
Eddy, CM, Rickards, HE, Cavanna, AE. The cognitive impact of antiepileptic drugs. Ther Adv Neurol Disord. 2011;4(6):385407. doi:10.1177/1756285611417920.CrossRefGoogle ScholarPubMed
Bari, A, Robbins, TW. Inhibition and impulsivity: behavioral and neural basis of response control. Prog Neurobiol. 2013;108:4479. doi:10.1016/j.pneurobio.2013.06.005.CrossRefGoogle ScholarPubMed