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Epidemiologic features of 65 Creutzfeldt–Jakob disease patients with a history of cadaveric dura mater transplantation in Japan

Published online by Cambridge University Press:  03 November 2000

Y. NAKAMURA ,
H. YANAGAWA ,
T. KITAMOTO  and
T. SATO
Y. NAKAMURA
Affiliation:
Department of Public Health, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi, Tochigi 329-0498, Japan
H. YANAGAWA
Affiliation:
Saitama Prefectural University
T. KITAMOTO
Affiliation:
Department of Neuropathology, Tohoku University School of Medicine
T. SATO
Affiliation:
Khonodai Hospital, National Center of Neurology and Psychiatry
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Abstract

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A total of 65 cases of Creutzfeldt–Jakob disease with a history of cadaveric dura transplantation in Japan were analysed to clarify the epidemiologic features of such patients and to explore whether other such patients will appear in the future. The age at transplantation averaged 44·4 years with a standard deviation of 14·4 years. The age at onset had an average of 53·0 years with a standard deviation of 14·1 years. The shortest latent period was 14 months, and the longest was 218 months with an average of 103·1 months and a standard deviation of 49·9 months. From the relationship between the calendar year at transplantation and the latent period, other such patients will appear in the near future. The current data suggested that several patients with Creutzfeldt–Jakob disease will occur from those receiving cadaveric dura mater grafts in the near future.

Type
Research Article
Information
Epidemiology & Infection , Volume 125 , Issue 1 , August 2000 , pp. 201 - 205
Copyright
© 2000 Cambridge University Press