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Attention-deficit/hyperactivity disorder (ADHD): from randomised controlled trials to evidence-based clinical services

Published online by Cambridge University Press:  09 January 2017

S. Cortese*
Affiliation:
Academic Unit of Psychology, Developmental Brain-Behaviour Laboratory, Solent NHS Trust and Faculty of Medicine, Clinical and Experimental Sciences (CNS and Psychiatry), University of Southampton, Southampton, UK The Child Study Center at NYU Langone Medical Center, New York, NY, USA
C. Barbui
Affiliation:
Department of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy
*
*Address for correspondence: S. Cortese, M.D., Ph.D., Academic Unit of Psychology, Developmental Brain-Behaviour Laboratory, University of Southampton, Southampton, UK. (Email: samuele.cortese@gmail.com)
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Abstract

Type
Editorials in This Issue
Copyright
Copyright © Cambridge University Press 2017 

Due to its high prevalence, significant impact on quality of life, and associated economic burden (Faraone et al. Reference Faraone, Asherson, Banaschewski, Biederman, Buitelaar, Ramos-Quiroga, Rohde, Sonuga-Barke, Tannock and Franke2015), attention-deficit/hyperactivity disorder (ADHD) is one of the most investigated conditions in child psychiatry and is of increasing interest to adult mental health professionals as well (De Crescenzo et al. Reference De Crescenzo, Cortese, Adamo and Janiri2016). A large number of efficacy randomised controlled trials (RCTs) have been published on the pharmacological (Banaschewski et al. Reference Banaschewski, Buitelaar, Chui, Coghill, Cortese, Simonoff and Wong2016) and non-pharmacological treatments of ADHD (Sonuga-Barke et al. Reference Sonuga-Barke, Brandeis, Cortese, Daley, Ferrin, Holtmann, Stevenson, Danckaerts, Van der Oord, Dopfner, Dittmann, Simonoff, Zuddas, Banaschewski, Buitelaar, Coghill, Hollis, Konofal, Lecendreux, Wong and Sergeant2013; Daley et al. Reference Daley, Van der Oord, Ferrin, Danckaerts, Doepfner, Cortese and Sonuga-Barke2014; Cortese et al. Reference Cortese, Ferrin, Brandeis, Buitelaar, Daley, Dittmann, Holtmann, Santosh, Stevenson, Stringaris, Zuddas and Sonuga-Barke2015, Reference Cortese, Ferrin, Brandeis, Holtmann, Aggensteiner, Daley, Santosh, Simonoff, Stevenson, Stringaris and Sonuga-Barke2016a ). A quick and approximate Pubmed search, using the following syntax: (ADHD [tiab] OR Attention Deficit [tiab] OR Hyperkinetic Syndrome [tiab]) and (randomized [tiab] OR randomised [tiab] OR RCT [tiab]), generated 1433 hits (search performed on 10.12.16). Has this large body of evidence been fully translated in the daily clinical practice to shape clinical services for individuals suffering from ADHD? The short answer is probably no. In fact, the evidence base for the implementation of clinical pathways and services for ADHD remains largely unexplored.

In this issue of the Journal, Professors Jan Buitelaar and David Coghill, two world class experts in ADHD, with an extensive research background and solid clinical experience, help us understand the main aspects and priorities in terms of implementation of evidence-based services for individuals with ADHD.

Professor Coghill (Reference Coghill2016) sets the scene providing a very comprehensive and thoughtful overview of the main issues that pertain to the implementation of clinical services for individuals who suffer from ADHD. He first reminds us that, whilst the provision of services, as well as the detection and treatment of the disorder, perhaps not surprisingly, vary across countries, there are some general principles that probably apply to the majority of countries in which care for ADHD is delivered. One of the main controversial aspects, when it comes to considering the practicalities of services for ADHD, relates to whom (child psychiatrists, psychiatrists, paediatricians, general practitioners, mental health professional, etc.) should provide the care to individuals with ADHD. Professor Coghill very pragmatically concludes that training, experience and availability of professionals are more relevant than their qualification. Few colleagues, we believe, might disagree on this. Importantly, he points to the need of implementing multidisciplinary services, offering a large range of clinical skills. Additionally, Professor Coghill highlights that, whilst ADHD symptoms in less complex cases could be treated in primary care, due to time constraints and lack of comprehensive training in psychopathology, general practitioners may easily miss important psychiatric comorbidities, which need to be taken into account to improve the overall quality of life of patients with ADHD. Another aspect to consider for the implementation of ADHD services relates to the type of outcomes that should be the focus of the treatment, as well as to the practical aspects of the clinical management, such intensity (number of contacts with clients) and type of management approach (unstructured v. standardised). The sentence ‘ADHD: a condition that is easy to treat but not easy to treat well’ very effectively summarises the issue. Recent empirical work by Coghill & Seth (Reference Coghill and Seth2015) has been instrumental in showing that a careful, standardised titration of medication, including guideline-based management of adverse effects, can make a significant difference in terms of sustained improvement of measured ADHD outcomes when compared to a less structured approach. Additionally, evidence points to a dissociation between ADHD core symptoms, namely, inattention, hyperactivity and impulsivity, and other aspects, such as executive dysfunction, that may add further challenges to individuals with ADHD. Additionally, I believe it is important to highlight here that mounting evidence is showing a significant association between ADHD and somatic conditions, such obesity (Cortese et al. Reference Cortese, Moreira-Maia, St Fleur, Morcillo-Penalver, Rohde and Faraone2016b ) or asthma (Instanes et al. Reference Instanes, Klungsoyr, Halmoy, Fasmer and Haavik2016). This means that focusing the care of ADHD on core symptoms only is less unlikely to improve the overall quality of life of patients with ADHD. Inevitably, targeting in an accurate and standardised way a number of ADHD-related outcomes requires not only commitment but also time. Whilst this is certainly challenging in many clinical services across countries, it should be matter of reflection for commissioners when allocating resources for ADHD services.

Arguably, one of the most urgent needs in terms of provision of care to individuals with ADHD relates to the management of youngsters in transition from child to adult health care system, as well as of adults with ADHD. The challenges related to the transition process include, among others, paucity of resources for adult services, lack of training or even scepticism around adult ADHD. In his editorial, Professor Buitelaar cleverly proposes that the key to facilitate the transition from child to adult services is to optimise the treatment of ADHD in adolescence. In fact, one of the main issues in the management of adolescents with ADHD relates to fluctuations in adherence to pharmacological treatment, due to a series of factors related to the medication (such as tolerability and formulation, with better adherence with extended release formulations), working relationship between patient/carers and clinician, and perception of stigma. Professor Buitelaar points to a series of strategies to enhance adherence to treatment in adolescents with ADHD. Three are particularly worthwhile: (1) Motivational interviewing (as opposed to direct persuasion from the clinician) to foster motivation to change elicited from the patient; (2) use of relatively novel technologies, such as smartphone apps for ecological momentary assessment, to allow for assessment of ADHD symptoms variability and feedback (ecological momentary intervention) to monitor and enhance adherence; and (3) mindfulness based training, to foster independent self-management.

At this stage, the suggestions provided in the two editorials remain largely untested from an empirical standpoint. In fact, very few randomised pragmatic trials have been carried out to gain insight into the most effective ways to deliver care to individuals with ADHD. Among these, it is worthy to cite here a community-based trial showing the effectiveness of a telehealth service model to manage ADHD in communities with limited access to specialised mental health care provision (Myers et al. Reference Myers, Vander, Zhou, McCarty and Katon2015) and a cluster randomised trial showing that collaborative consultative services, based on the promotion of collaboration between community-based practitioners and mental health professionals, are effective to improve clinical outcomes related to ADHD (Epstein et al. Reference Epstein, Rabiner, Johnson, Fitzgerald, Chrisman, Erkanli, Sullivan, March, Margolis, Norton and Conners2007).

We hope that the editorials by Professors Buitelaar and Coghill will inspire not only future pragmatic randomised controlled trials, but also stakeholders, commissioners and practitioners when considering how best to design evidence-based clinical services and pathways for individuals with ADHD across the lifespan.

Financial Support

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Conflict of Interest

None.

References

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