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Staurosporine advances interblastomeric flattening of the mouse embryo

  • D. Michael O'Sullivan (a1), Martin H. Johnson (a1) and Josie M.L. McConnell (a1)

Extract

Staurosporine, an inhibitor of protein kinase activity, causes premature intercellular flattening of blastomeres but does not induce their premature polarisation. The flattening induced is calcium dependent, is reversed transiently at mitosis and requires the continuing presence of the drug. Staurosporine also blocks the decompacting effect of phorbol ester on 8-cell embryos.

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Corresponding author

Professor M.H. Johnson, Embryo and Gamete Research Group, Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK. Telephone: (0223) 333789. Fax: (0223) 333786.

References

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Keywords

Staurosporine advances interblastomeric flattening of the mouse embryo

  • D. Michael O'Sullivan (a1), Martin H. Johnson (a1) and Josie M.L. McConnell (a1)

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