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Mast cell-Leydig cell relationships in the testis of the lizard podarcis s. sicula Raf: thermal manipulation, ethane 1,2-dimethane sulphonate (EDS) and sex hormone treatment

Published online by Cambridge University Press:  26 September 2008

Sergio Minucci ,
Italia Izzo Vitiello ,
Concetta Marmorino ,
Loredana Di Matteo  and
Gabriella Chieffi Baccari
Sergio Minucci*
Affiliation:
Dipatimento di Fisiologia Umana e Funzioni Biologiche Integrate ‘Filippo Bottazzi’ and Istituto di Anatomia Umana Normale, Seconda Università degli Studi di Napoli, Naples, Italy
Italia Izzo Vitiello
Affiliation:
Dipatimento di Fisiologia Umana e Funzioni Biologiche Integrate ‘Filippo Bottazzi’ and Istituto di Anatomia Umana Normale, Seconda Università degli Studi di Napoli, Naples, Italy
Concetta Marmorino
Affiliation:
Dipatimento di Fisiologia Umana e Funzioni Biologiche Integrate ‘Filippo Bottazzi’ and Istituto di Anatomia Umana Normale, Seconda Università degli Studi di Napoli, Naples, Italy
Loredana Di Matteo
Affiliation:
Dipatimento di Fisiologia Umana e Funzioni Biologiche Integrate ‘Filippo Bottazzi’ and Istituto di Anatomia Umana Normale, Seconda Università degli Studi di Napoli, Naples, Italy
Gabriella Chieffi Baccari
Affiliation:
Dipatimento di Fisiologia Umana e Funzioni Biologiche Integrate ‘Filippo Bottazzi’ and Istituto di Anatomia Umana Normale, Seconda Università degli Studi di Napoli, Naples, Italy
*
S. Minucci, Dipartimento di Fisiologia Umana e Funzioni Biologiche Integrate ‘F. Bottazzi’, via Costantinpoli, 16, I-80138 Naples, Italy. Telephone: +39 (81) 5665829 Fax: +39 (81) 5665820.
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Summary

Mast cells of connective tissue type are scattered in the interstitial compartment of the lizard Podarcis s. sicula. Their number varies during the year, showing peaks in spring and in winter, respectively.Thermal manipulation affects mast cell number (MCN): high temperature decreased MCN in both January and May, while low temperature increased MCN only in January. Ethane dimethane sulphonate, a toxin which specifically destroys Leydig cells, induced an increase in MCN on days 3 and 7 of treatment. Oestradiol treatment provoked a strong increase in MCN that was blocked by tamoxifen. Blocking androgen receptors with cyproterone acetate resulted in an increase in MCN, while testosterone injection provoked a strong decrease. These results suggest a relationship between the presence of mature Leydig cells and mast cell proliferation and/or differentiation.

Keywords

Leydig cellMast cellReptilesSex hormonesTestis
Type
Article
Information
Zygote , Volume 3 , Issue 3 , August 1995 , pp. 259 - 264
Copyright
Copyright © Cambridge University Press 1995

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