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Gonadotrophin-releasing hormone agonist triggering may improve central oocyte granularity and embryo quality

Published online by Cambridge University Press:  03 April 2020

Kuo-Chung Lan Open the ORCID record for Kuo-Chung Lan [Opens in a new window] ,
Yu-Chen Chen ,
Yi-Chi Lin  and
Yi-Ru Tsai
Kuo-Chung Lan*
Affiliation:
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Center for Menopause and Reproductive Medicine Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Yu-Chen Chen
Affiliation:
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Yi-Chi Lin
Affiliation:
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Yi-Ru Tsai
Affiliation:
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
*
Author for correspondence: Kuo-Chung Lan, Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung City, Taiwan. Tel: +886 7 7317123 ext. 8916; Fax: +886 7 7322915. E-mail: lankuochung@gmail.com
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Summary

This study aimed to describe outcomes in four women aged 28–34 years with central cytoplasmic granulation (CCG) of the oocytes who underwent in vitro fertilization/intracytoplasmic sperm injection (ICSI) using gonadotrophin-releasing hormone (GnRH) agonist to replace human chorionic gonadotrophin (hCG) as a trigger of final oocyte maturation. The initial ICSI procedure showed that all four women had CCG of the ooplasm and poor quality embryos. Subsequent ICSI used an antagonist protocol with a GnRH agonist trigger replacing the agonist protocol, plus hCG triggered ovulation. Ooplasm and embryo quality were improved in all four patients. All four became pregnant and gave birth to live infants. This study provides GnRH agonist triggering that may improve ooplasm granularity and embryo quality.

Keywords

Centrally cytoplasmic granulationEmbryo qualityGnRH agonist triggerHuman chorionic gonadotrophin triggerICSI
Type
Short Communication
Information
Zygote , Volume 28 , Issue 4 , August 2020 , pp. 337 - 343
Copyright
© Cambridge University Press 2020

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Footnotes

*

These authors contributed equally to this work.

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