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Expectations and limitations of ovarian tissue transplantation

  • N.J. Donfack (a1), K.A. Alves (a1), V.R. Araújo (a1), A. Cordova (a2) (a3), J.R. Figueiredo (a1), J. Smitz (a4) and A.P.R. Rodrigues (a5)...

Summary

Constant progress in the diagnosis and treatment of cancer disease has increased the number and prognosis of cancer survivors. However, the toxic effects of chemotherapy and radiotherapy on ovarian function have resulted in premature ovarian failure. Patients are, therefore, still expecting methods to be developed to preserve their fertility successfully. Several potential options are available to preserve fertility in patients who face premature ovarian failure, including immature or mature oocyte and embryo cryopreservation. However, for children or prepubertal women needing immediate chemotherapy, cryopreservation of ovarian tissue is the only alternative. The ultimate aim of this strategy is to implant ovarian tissue into the pelvic cavity (orthotopic site) or in a heterotopic site once oncological treatment is completed and the patient is disease free. Transplantation of ovarian tissue with sufficiently large numbers of follicles could potentially restore endocrine function and allow multiple cycles for conception. However, the success of ovarian tissue transplantation still has multiple challenges, such as the low number of follicles in the graft that may affect their longevity as well as the survival of the tissue during ex vivo processing and subsequent transplantation. Therefore, this review aims to summarize the achievements of ovary grafting and the potential techniques that have been developed to improve ovarian graft survival.

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Corresponding author

All correspondence to: A.P.R. Rodrigues. Programa de Pós-Graduação em Ciências Veterinárias (PPGCV). Laboratório de Manipulação de Oócitos e Folículos Pré-Antrais (LAMOFOPA). Universidade Estadual do Ceará (UECE). Av. Paranjana, 1700, Campus do Itaperi. FortalezaCEBrasil. CEP: 60740 903. Tel: +55 85 3101 9852. Fax: +55 85 3101 9840. E-mail: aprrodriguespapers@gmail.com

References

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Agca, C., Lucy, M.C. & Agca, Y. (2009). Gene expression profile of rat ovarian tissue following xenotransplantation into immune-deficient mice. Reproduction 137, 957–67.
Amorim, C.A., David, A., Dolmans, M.M., Camboni, A., Donnez, J. & Langendonckt, A.V. (2011). Impact of freezing and thawing of human ovarian tissue on follicular growth after long-term xenotransplantation. J. Assist. Reprod. Genet. 28, 1157–65.
Amorim, C.A., Jacobs, S., Devireddy, R.V., Langendonckt, A.V., Vanacker, J., Jaeger, J., Luyckx, V., Donnez, J. & Dolmans, M.M. (2013). Successful vitrification and autografting of baboon (Papio anubis) ovarian tissue. Hum. Reprod. 28, 2146–56.
Anderson, R.A. & Wallace, W.H.B. (2013). Antimullerian hormone, the assessment of the ovarian reserve and the reproductive outcome of the young patient with cancer. Fertil. Steril. 99, 14 6975.
Andersen, C.Y., Rosendahl, M., Byskov, A.G., Loft, A., Ottosen, C., Dueholm, M., Kirsten, L.T. Schmidt KL.T., Andersen, A.N. & Ernst, E. (2008). Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum. Reprod. 23, 2266–72.
Aubard, Y. (2003). Ovarian tissue xenografting. Eur. J. Obstet. Gynecol. Reprod. Biol. 108, 14–8.
Baird, D.T., Webb, R., Campbell, B.K., Harkness, L.M. & Gosden, R.G. (1999). Long-term ovarian function in sheep after ovariectomy and transplantation of autografts stored at −196°C. Endocrinology 140, 462–71.
Bedaiwy, M.A. & Falcone, T. (2010). Whole ovary transplantation. Clin. Obstet. Gynecol. 53, 797803.
Bordes, A., Lornage, J., Demirci, B., Franck, M., Courbiere, B., Guerin, J.F. & Salle, B. (2005). Normal gestations and live births after orthotopic autograft of vitrified–warmed hemi-ovaries into ewes. Hum. Reprod. 20, 2745–8.
Bosma, G.C., Custer, R.P. & Bosma, M.J. (1983). A severe combined immunodeficiency mutation in the mouse. Nature 301, 527–30.
Burmeister, L., Kovacs, G.T. & Osianlis, T. (2013). First Australian pregnancy after ovarian tissue cryopreservation and subsequent autotransplantation. Med. J. Aust. 198, 158–9.
Campbell, B.K., Telfer, E.E., Webb, R. & Baird, D.T. (2004). Evidence of a role for follicle-stimulating hormone in controlling the rate of preantral follicle development in sheep. Endocrinology 145, 1870–9.
Campbell, B.K., Hernandez-Medrano, J., Onions, V., Pincott-Allen, C., Aljaser, F., Fisher, J., McNeilly, A.S., Webb, R. & Picton, H.M. (2014). Restoration of ovarian function and natural fertility following the cryopreservation and autotransplantation of whole adult sheep ovaries. Hum. Reprod. 29, 1749–63.
Candy, C.J., Wood, M.J. & Whittingham, D.G. (2000). Restoration of a normal reproductive lifespan after grafting of cryopreserved mouse ovaries. Hum. Reprod. 15, 1300–4.
César, J.M., Petroianu, A., Vasconcelos, L. de, S., Cardoso, V.N., Mota, L.D., Barbosa, A.J., Soares, C.D. & De Oliveir, A.L. (2015). Preliminary study of coconut water for graft tissues preservation in transplantation. Rev. Col. Bras. Cir. 42, 43–8.
Commin, L., Buff, S., Rosset, E., Galet, C., Allard, A., Bruyere, P., Joly, T., Guerin, P. & Neto, V. (2012). Follicle development in cryopreserved bitch ovarian tissue grafted to immunodeficient mouse. Reprod. Fertil. Dev. 24, 46.
Custer, R.P., Bosma, G.C. & Bosma, M.J. (1985). Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am. J. Pathol. 120, 464–77.
Demeestere, I., Simon, P., Emiliani, S., Delbaere, A. & Englert, Y. (2009). orthotopic and heterotopic ovarian tissue transplantation. Hum. Reprod. Update 15, 649–65.
Demeestere, I., Simon, P., Moffa, F., Delbaere, A. & Englert, Y. (2010). Birth of a second healthy girl more than 3 years after cryopreserved ovarian graft. Hum. Reprod. 25, 1590–1.
Donnez, J. & Dolmans, M.M. (2013). Fertility preservation in women. Nat. Rev. Endocrinol. 9, 735–49.
Donnez, J. & Dolmans, M.M. (2014). Transplantation of ovarian tissue. Best Pract. Res. Clin. Obstet. Gynaecol. 28, 1188–97.
Donnez, J. & Dolmans, M.M. (2015). Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice. J. Assist. Reprod. Genet. 32, 1167–70.
Donnez, J., Dolmans, M.M., Demylle, D., Jadoul, P., Pirard, C., Squifflet, J., Martinez-Madrid, B. & Van Langendonckt, A. (2004). Live birth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet 364, 1405–10.
Donnez, J., Dolmans, M.M., Demylle, D., Jadoul, P., Pirard, C., Squifflet, J., Martinez-Madrid, B. & Van Langendonckt, A. (2006a). Restoration of ovarian function after orthotopic (intraovarian and periovarian) transplantation of cryopreserved ovarian tissue in a woman treated by bone marrow transplantation for sickle cell anaemia: case report. Hum. Reprod. 21, 183–8.
Donnez, J., Martinez-Madrid, B., Jadoul, P., Van Langendonckt, A., Demylle, D. & Dolmans, M.M. (2006b). Ovarian tissue cryopreservation and transplantation: a review. Hum. Reprod. Update 12, 519–35.
Donnez, J., Squifflet, J., Van Eyck, A.S., Demylle, D., Van Langendonckt, A. & Dolmans, M.M. (2008). Restoration of ovarian function in orthotopically transplanted cryopreserved ovarian tissue: a pilot experience. Reprod. Biomed. Online 16, 694704.
Donnez, J., Jadoul, P., Squifflet, J., Van Langendonckt, A., Donnez, O., Van Eyck, A.S., Marinescu, C. & Dolmans, M.M. (2010a). Ovarian tissue cryopreservation and transplantation in cancer patients. Best Pract. Res. Clin. Obstet. Gynecol. 24, 87100.
Donnez, J., Squifflet, J., Pirard, C., Jadoul, P. & Dolmans, M.M. (2010b). Restoration of ovarian function after allografting of ovarian cortex between genetically non-identical sisters. Hum. Reprod. 25, 2489–95.
Donnez, J., Squifflet, J., Pirard, C., Demylle, D., Delbaere, A., Armenio, L., Englert, Y., Cheron, A.C., Jadoul, P. & Dolmans, M.M. (2011). Live birth after allografting of ovarian cortex between genetically non-identical sisters. Hum. Reprod. 26, 1384–8.
Donnez, J., Dolmans, M.M., Pellicer, A., Diaz-garcia, C., Serrano, M.S., Schmidt, K.T., Ernst, E., Luyckx, V. & Andersen, C.Y. (2013). Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertil. Steril. 99, 1503–13.
Ernst, E., Bergholdt, S., Jorgensen, J.S. & Andersen, C.Y. (2010). The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue. Hum. Reprod. 25, 1280–1.
Fassbender, M., Hildebrandt, T.B., Paris, MC.J., Colenbrander, B. & Jewgenow, K. (2007). High-resolution ultrasonography of xenografted domestic cat ovarian cortex. J. Reprod. Dev. 53, 1023–34.
Ferrara, N. & Davis-Smyth, T. (1997). The biology of vascular endothelial growth factor. Endocrine Ver. 18, 425.
Filatov, M.A., Khramova, Y.V., Kiseleva, M.V., Malinova, I.V., Komarova, E.V. & Semenova, M.L. (2016). Female fertility preservation strategies: cryopreservation and ovarian tissue in vitro culture, current state of the art and future perspectives. Zygote 24, 635–53.
Fransolet, M., Henry, L., Labied, S., Masereel, M.C., Blacher, S., Noël, A., Foidart, J.M., Nisolle, M. & Munaut, C. (2015). Influence of mouse strain on ovarian tissue recovery after engraftment with angiogenic factor. J. Ova. Res. 15, 142–6.
Fu, S., Wang, J., Sun, W., Xu, Y., Zhou, X. & Cheng, W. (2014). Preclinical humanized mouse model with ectopic ovarian tissues. Exp. Therapeut. Med. 8, 742–6.
Gavish, Z., Ben-Haim, M. & Arav, A. (2008). Cryopreservation of whole murine and porcine livers. Rejuvenation Res. 11, 765–72.
Gavish, Z., Peer, G., Hadassa, R., Yoram, C. & Meirow, D. (2014). Follicles activation and burn-out contribute to post-transplantation follicles loss in ovarian tissue grafts: the effect of graft thickness. Hum. Reprod. 29, 989–96.
Gerhardt, H. & Betsholtz, C. (2003). Endothelial–pericyte interactions in angiogenesis. Cell Tissue Res. 314, 1523.
Gosden, R.G., Baird, D.T., Wade, J.C. & Webb, R. (1994). Restoration of fertility to oophorectomized sheep by ovarian autografts stored at −196°C. Hum. Reprod. 9, 597603.
Gosden, R.G., Robert, T. & Morris, M.D. (2010). Appreciation of an enlightened surgeon and pioneer of ovarian transplantation. Fertil. Steril. 94, 1960–3.
Grazul-Bilska, A.T., Banerjee, J., Yazici, I., Borowczyk, E., Bilski, J.J., Sharma, R.K., Siemionov, M. & Falcone, T. (2008). Morphology and function of cryopreserved whole ovine ovaries after heterotopic autotransplantation. Reprod. Biol. Endocrinol. 6, 115.
Greenaway, J., Connor, K., Hanne, G., Pedersen, Brenda, Coomber, L., Lamarre, J. & Petrik, J. (2004). Vascular endothelial growth factor and its receptor, Flk-1/KDR, are cytoprotective in the extravascular compartment of the ovarian follicle. Endocrinology 145, 2896–905.
Henry, L., Labied, S., Fransolet, M., Kirschvink, N., Blacher, S., Noël, A., Foidart, J.M., Nisolle, M. & Munaut, C. (2015). Isoform 165 of vascular endothelial growth factor in collagen matrix improves ovine cryopreserved ovarian tissue revascularisation after xenotransplantation in mice. Reprod. Biol. Endocrinol. 13, 12.
Igarashi, S., Suzuki, N., Hashimoto, S., Takae, S., Takenoshita, M., Hosoi, Y., Morimoto, Y. & Ishizuka, B. (2010). Heterotopic autotransplantation of ovarian cortex in cynomolgus monkeys. Hum. Cell 23, 2634.
Imhof, M., Bergmeister, H., Lipovac, M., Rudas, M., Hofstetter, G. & Huber, J. (2006). Orthotopic microvascular reanastomosis of whole cryopreserved ovine ovaries resulting in pregnancy and live birth. Fertil. Steril. 85, 1208–15.
Ingec, M., Isaoglu, U., Yilmaz, M., Calik, M., Polat, B., Alp, H.H., Kurt, A., Gundogdu, C. & Suleyman, H. (2011). Prevention of ischemia–reperfusion injury in rat ovarian tissue with the on-off method. J. Physiol. Pharmacol. 62, 575–82.
Ishijima, T., Abe, Y. & Suzuki, H. (2009). Loss of the cryopreserved canine ovary after xenotransplantation. J. Mamm. 26, 61–5.
Jafarabadi, M., Abdollahi, M. & Salehnia, M. (2015). Assessment of vitrification outcome by xenotransplantation of ovarian cortex pieces in γ-irradiated mice: morphological and molecular analyses of apoptosis. J. Assist. Reprod. Genet. 32, 195205.
Jemal, A., Siegel, R., Xu, J. & Ward, E. (2012). Cancer statistics. CA Cancer J. Clin. 60, 277300.
Kagawa, N., Silber, S. & Kuwayama, M. (2009). Successful vitrification of bovine and human ovarian tissue. Reprod. Biomed. Online 18, 568–77.
Kim, J.S., Qian, T. & Lemasters, J.J. (2003). Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology 124, 494503.
Kim, J.Y. (2012). Control of ovarian primordial follicle activation. Clin. Exp. Reprod. Med. 39, 10–4.
Kim, S.S. (2010). Time to re-think: ovarian tissue transplantation versus whole ovary transplantation. Reprod. Biomed. Online 20, 171–4.
Kim, S.S. (2014). Revisiting the role of heterotopic ovarian transplantation: futility or fertility. Reprod. BioMed. Online 28, 141–5.
Kim, S.S., Hwang, I.T. & Lee, H.C. (2004). Heterotopic autotransplantation of cryobanked human ovarian tissue as a strategy to restore ovarian function. Fertil. Steril. 82, 930–2.
Kim, S.S., Lee, W.S., Chung, M.K., Lee, H.C., Lee, H.H. & Hill, D. (2009). Long-term ovarian function and fertility after heterotopic autotransplantation of cryobanked human ovarian tissue: 8-year experience in cancer patients. Fertil. Steril. 91, 2349–54.
Labied, S., Delforge, Y., Munaut, C., Blacher, S., Colige, A., Delcombel, R., Henry, L., Fransolet, M., Jouan, C., D'Hauterive, S.P., Noël, A., Nisolle, M. & Foidart, J.M. (2013). Isoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation. Transplantation 95, 426–33.
Liu, L.J., Xie, X.Y., Zhang, R.Z., Xu, P., Bujard, H. & Jun, M. (2008). Reproduction and fertility in wild-type and transgenic mice after orthotopic transplantation of cryopreserved ovaries from 10-d-old mice. Res. Note 37, 353–7.
Lotz, L., Liebenthron, J., Nichols-Burns, S., Montag, M., Hoffmann, I., Beckmann, M.W., van der Ven, H., Töpfer, D. & Dittrich, R. (2014). Spontaneous antral follicle formation and metaphase II oocyte from a non-stimulated prepubertal ovarian tissue xenotransplant. Reprod. Biol. Endocrinol. 12, 41.
Luyckx, V., Pharm, B., Soares, M., Scalercio, S., Jadoul, P., Amorim, C.A., Soares, M., Donnez, J. & Dolmans, M.M. (2013). Evaluation of cryopreserved ovarian tissue from prepubertal patients after long-term xenografting and exogenous stimulation. Fertil. Steril. 100, 1350–7.
Martinez-Madrid, B., Donnez, J., Van Eyck, A.S., Veiga-Lopez, A., Dolmans, M.M. & Van Langendonckt, A. (2009). Chick embryo chorioallantoic membrane (CAM) model: a useful tool to study short-term transplantation of cryopreserved human ovarian tissue. Fertil. Steril. 91, 285–92.
Meirow, D., Baum, M., Yaron, R., Levron, J., Hardan, I., Schiff, E., Nagler, A., Yehuda, D.B., Raanani, H. & Hourvitz, A. (2007). Ovarian tissue cryopreservation in hematologic malignancy: 10 years’ experience. Leuk. Lymphoma 48, 1569–76.
Mhatre, P. & Mhatre, J. (2006). Orthotopic ovarian transplant-review and 3 surgical techniques. Pediatr. Transplant. 10, 782–7.
Oktay, K., Economos, K., Kan, M., Rucinski, J., Veeck, L. & Rosenwaks, Z. (2001). Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm. JAMA 286, 1490–3.
Parrot, D.M.V. (1960). The fertility of mice with orthotopic ovarian grafts derived from frozen tissue. J. Reprod. Fertil. 1, 230–41.
Paulini, F., Vilela, JM.V., Chiti, M.C., Donnez, J., Jadoul, P., Dolmans, M.M. & Amorim, C.A. (2016). Survival and growth of human preantral follicles after cryopreservation of ovarian tissue, follicles isolation and short-term xenografting. Reprod. BioMed. Online 33, 425–32.
Prochazka, M., Gaskins, H.R., Shultz, L.D. & Leiter, E.H. (1992). The non-obese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Immunology 88, 3290–4.
Revel, A., Laufer, N., Ben Meir, A., Lebovich, M. & Mitrani, E. (2011). Micro organ ovarian transplantation enables pregnancy: a case report. Hum. Reprod. 26, 1097–103.
Revelli, A., Marchino, G., Dolfin, E., Molinari, E., Delle Piane, L., Salvagno, F. & Benedetto, C. (2013). Live birth after orthotopic grafting of autologous cryopreserved ovarian tissue and spontaneous conception in Italy. Fertil. Steril. 99, 227–30.
Rodriguez-Wallberg, K.A. & Oktay, K. (2012). Recent advances in oocyte and ovarian tissue cryopreservation and transplantation. Best Pract. Res. Clin. Obstet. Gynaecol. 26, 391405.
Rodriguez-Wallberg, K.A., Karlstr, P.O., Rezapour, M., Castellanos, E., Hreinsson, J., Rasmussen, C., SheikhI, M., Ouvrier, B., Bozoky, B., Olofsson, J.I., Lundqvist, M. & Hovatta, O. (2015). Full-term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy. Acta Obstet. Gynecol. Scand. 94, 324–8.
Salle, B., Demirci, B., Franck, M., Rudigoz, R.C., Guerin, J.F. & Lornage, J. (2002). Normal pregnancies and live births after autograft of frozen–thawed hemi-ovaries into ewes. Fertil. Steril. 77, 403–8.
Salle, B., Demirci, B., Franck, M., Berthollet, C. & Lornage, J. (2003). Long-term follow-up of cryopreserved hemi-ovary autografts in ewes: pregnancies, births, and histologic assessment. Fertil. Steril. 80, 172–7.
Santos, R.R., Knijn, H.M., Vos, PLA.M., Oei, CH.Y., Loon, T.V., Colenbrander, B., Gadella, B.M., van den Hurk, R. & Roelen, B.A.J. (2009). Complete follicular development and recovery of ovarian function of frozen–thawed, autotransplanted caprine ovarian cortex. Fertil. Steril. 91, 1455–8.
Scalercio, S.R., Amorim, C.A., Brito, D.C., Percario, S., Oskam, I.C., Domingues, S.F.S. & Santos, R.R. (2015). Trolox enhances follicular survival after ovarian tissue autograft in squirrel monkey (Saimiri collinsi). Reprod. Fertil. Dev. [Epub ahead of print]
Schmidt, K.L.T., Ernst, E., Byskov, A.G., Nyboe Andersen, A. & Yding Andersen, C. (2003). Survival of primordial follicles following prolonged transportation of ovarian tissue prior to cryopreservation. Hum. Reprod. 18, 2654–9.
Schnorr, J., Oehninger, S., Toner, J., Hsiu, J., Lanzendorf, S., Williams, R. & Hodgen, G. (2002). Functional studies of subcutaneous ovarian transplants in non-human primates: steroidogenesis, endometrial development, ovulation, menstrual patterns and gamete morphology. Hum. Reprod. 17, 612–9.
Schubert, B., Canis, M., Darcha, C., Artonne, C., Smitz, J. & Grizard, G. (2008). Follicular growth and estradiol follow-up after subcutaneous xenografting of fresh and cryopreserved human ovarian tissue. Fertil. Steril. 89, 1787–94.
Scott, J.R., Hendrickson, M., Lash, S. & Shelby, J. (1987). Pregnancy after tubo ovarian transplantation. Obstet. Gynecol. 70, 229234.
Shultz, L.D., Ishikawa, F. & Greiner, D.L. (2007). Humanized mice in translational biomedical research. Nat. Rev. Immunol. 7, 118–30.
Silber, S.J. (2012). Ovary cryopreservation and transplantation for fertility preservation. Mol. Hum. Reprod. 18, 5967.
Silber, S.J. (2016). Ovarian tissue cryopreservation and transplantation: scientific implications. J. Assist. Reprod. Genet. 33, 15951603.
Silber, S.J., Lenahan, K.M., Levine, D.J., Pineda, J.A., Gorman, K.S., Friez, M.J., Crawford, E.C. & Gosden, R.G. (2005). Ovarian transplantation between monozygotic twins discordant for premature ovarian failure. New Engl. J. Med. 353, 5863.
Silber, S.J., De Rosa, M., Pineda, J., Lenahan, K., Grenia, D., Gorman, K. & Gosden, R.G. (2008). A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation. Hum. Reprod. 23, 1531–57.
Sonmezer, M. & Oktay, K. (2010). Orthotopic and heterotopic ovarian tissue transplantation. Best Prac. Res. Clin. Obstet. Gynaecol. 24, 113–26.
Stern, C.J., Toledo, M.G., Hale, L.G., Gook, D.A. & Edgar, D.H. (2011). The first Australian experience of heterotopic grafting of cryopreserved ovarian tissue: evidence of establishment of normal ovarian function. Aust. NZ J. Obstet. Gynecol. 51, 268–75.
Stern, C.J., Gook, D., Hale, L.G., Agresta, F., Oldham, J., Rozen, G. & Jobling, T. (2013). First reported clinical pregnancy following heterotopic grafting of cryopreserved ovarian tissue in a woman after a bilateral oophorectomy. Hum. Reprod. 28, 2996–9.
Stoop, D., Cobo, A. & Silber, S. (2014). Fertility preservation for age-related fertility decline. Lancet 384, 1311–9.
Suzuki, N., Hashimoto, S., Igarashi, S., Yamanaka, M., Yamochi, T., Takenoshita, M., Hosoi, Y., Morimoto, Y. & Ishizuka, B. (2012). Assessment of long-term function of heterotopic transplants of vitrified ovarian tissue in cynomolgus monkeys. Hum. Reprod. 27, 2420–9.
Van Eyck, A.S., Jordan, B.F., Gallez, B., Heilier, J.F., Van Langendonckt, A. & Donnez, J. (2009). Electron paramagnetic resonance as a tool to evaluate human ovarian tissue reoxygenation after xenografting. Fertil. Steril. 92, 374–81.
Van Langendonckt, A., Romeu, L., Ambroise, J., Amorim, C.A., Bearzatto, B., Gala, J.L., Donnez, J. & Dolmans, M.M. (2014). Gene expression in human ovarian tissue after xenografting. Mol. Hum. Reprod. 20, 514–25.
Vollmar, B., Glasz, J., Menger, M.D. & Messmer, K. (1995). Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence. Surgery 117, 195200.
Wang, Y., Chang, Q., Sun, J., Dang, L., Ma, W., Hei, C., Shen, X., Zhao, C., Cai, Y., Pei, X., Zhang, X. & Jiang, X. (2012). Effects of HMG on revascularization and follicular survival in heterotopic autotransplants of mouse ovarian tissue. Reprod. BioMed. Online 24, 646–53.
Wang, L., Ying, Y.F., Ouyang, Y.L., Wang, J.F. & Xu, J. (2013). VEGF and bFGF increase survival of xenografted human ovarian tissue in an experimental rabbit model. J. Assist. Reprod. Genet. 30, 1301–11.
Yang, H.Y., Cox, S.L., Jenkin, G., Findlay, J., Trounson, A. & Shaw, J. (2006). Graft site and gonadotrophin stimulation influences the number and quality of oocytes from murine ovarian tissue grafts. Reproduction 131, 851–9.
Yi-Hsin, L., Yu-Chi, Y., Chii-Ruey, T., Wei-Jen, S., Jah-Yao, L. & Chi-Huang, C. (2011). Evaluating the effects of immunosuppression by in-vivo bioluminescence imaging after allotransplantation of ovarian grafts. Reprod. BioMed. Online 22, 220–7.
Youm, H.W., Lee, J.R., Lee, J., Jee, B.C., Suh, C.S. & Kim, SH. (2015). Transplantation of mouse ovarian tissue: comparison of the transplantation sites. Theriogenology 83, 854–61.
Zelinski, M.B., Murphy, M.K., Lawson, M.S., Jurisicova, A., Pau, KY.F., Toscano, N.P., Jacob, D.S., Fanton, J.K., Casper, R.F., Dertinger, S.D. & Tilly, J.L. (2011). In-vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female non-human primates. Fertil. Steril. 95, 1440–5.
Zhang, H., Yang, Y., Ma, W., Wu, H., Zheng, X., Hei, C., Sun, M., Ma, W.M.H., Chang, Q., Wang, H., Cai, Y., Xie, Y., Zhao, C., Pei, X. & Wang, Y. (2016). The revascularization and follicular survival of mouse ovarian grafts treated with fsh during cryopreservation by vitrification. CryoLetters 37, 88102.
Zhang, J.M., Sheng, Y., Cao, Y.Z., Wang, H.Y. & Chen, Z.J. (2011). Cryopreservation of whole ovaries with vascular pedicles: vitrification or conventional freezing? J. Assist. Reprod. Genet. 28, 445–52.
Zhang, Q., Wang, S.M., Yao, P.B., Zhang, L., Zhang, Y.J., Chen, R.X., Fu, Y. & Zhang, J.M. (2015). Effects of l-carnitine on follicular survival and graft function following autotransplantation of cryopreserved-thawed ovarian tissues. Cryobiology 71, 135–40.

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