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Effects of in vitro exposure of sheep ovarian tissue to zearalenone and matairesinol on preantral follicles

Published online by Cambridge University Press:  25 October 2021

D.C.C. Brito ,
I.P. Silva ,
A.C.A. Ferreira ,
N.A.R. Sá ,
M.I.F. Guedes ,
A.P.R. Rodrigues ,
R.R. Santos Open the ORCID record for R.R. Santos [Opens in a new window]  and
J.R. Figueiredo
D.C.C. Brito
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
I.P. Silva
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
A.C.A. Ferreira
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
N.A.R. Sá
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
M.I.F. Guedes
Affiliation:
Laboratory of Biotechnology and Molecular Biology (LBBM), State University of Ceará, Fortaleza60714-903, CE, Brazil
A.P.R. Rodrigues
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
R.R. Santos*
Affiliation:
Schothorst Feed Research, 8218 NA Lelystad, The Netherlands
J.R. Figueiredo
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
*
Author for correspondence: R.R. Santos. Schothorst Feed Research, 8218 NA Lelystad, The Netherlands. E-mail: rsantos@schothorst.nl
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Summary

The aim of this study was to evaluate the effect of 1 µmol/l zearalenone (ZEN) and 1 µmol/l matairesinol (MAT), alone or in combination, on the morphology of in vitro-cultured ovarian preantral follicles. Ovaries from four adult sheep were collected at a local slaughterhouse and fragmented, and the ovarian pieces were submitted to in vitro culture for 3 days in the presence or absence of the test compounds. The morphology of primordial and primary follicles was impaired by ZEN. The plant lignan MAT alone did not maintain the morphology of the ovarian follicles; its combination with ZEN counteracted the negative effects observed when follicles were cultured in the presence of the mycotoxin alone. However, MAT was not able to promote the in vitro development of the ovarian follicles.

Keywords

Follicular developmentHistologyIn vitro cultureMycoestrogenPhytoestrogen
Type
Short Communication
Information
Zygote , Volume 30 , Issue 3 , June 2022 , pp. 419 - 422
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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