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Effect of anti-PMSG on distribution of estrogen receptor alpha and progesterone receptor in mouse ovary, oviduct and uterus

  • Zi Li Lin (a1), He Min Ni (a2), Yun Hai Liu (a2), Xi Hui Sheng (a2), Xiang Shun Cui (a1), Nam Hyung Kim (a1) and Yong Guo (a3)...

Summary

It is well established that estrogen and progesterone are critical endogenous hormones that are essential for implantation and pregnancy in females. However, the distribution of estrogen receptor α (ERα) and progesterone receptor (PR) in female reproductive tracts is elusive. Herein, we report that after serial treatments with pregnant mare's serum gonadotrophin (PMSG) with or without anti-PMSG (AP), mice could regulate the distribution of ERα and PR in the murine ovary, oviduct and uterus and the level of estradiol in serum. ERα and PR regulation by PMSG and anti-PMSG was estrous cycle-dependent and critical for promoting the embryo-implantation period. Furthermore, our results suggested that AP-42 h treatment is more effective than the other treatments. In contrast, other treatment groups also affected the distribution of ERα and PR in mouse reproductive tracts. Thus, we found that anti-PMSG has the potential to restore the distribution of ERα and PR, which could effectively reduce the negative impact of residual estrogen caused by the normal superovulation effect of PMSG in mice.

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Corresponding author

All correspondence to: Yong Guo. College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China. Tel: +86 10 80799133. Fax: +86 10 80799468. e-mail: y63guo@126.com

References

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Alexiadis, M., Eriksson, N., Jamieson, S., Davis, M., Drummond, AE., Chu, S., Clyne, C.D., Muscat, G.E. & Fuller, P.J. (2011). Nuclear receptor profiling of ovary granulosa cell tumors. Horm. Cancer 2, 157–69.
Das, S.K., Wang, X.N., Paria, B.C., Damm, D., Abraham, J.A., Klagsbrun, M., Andrews, G.K. & Dey, S.K. (1994). Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. Development 120, 1071–83.
Dehdashti, F., Mortimer, J.E., Trinkaus, K., Naughton, M.J., Ellis, M., Katzenellenbogen, J.A., Welch, M.J. & Siegel, B.A. (2009). PET-based estrogen challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor positive breast cancer. Breast Cancer. Res. Treat, 113, 509–17.
Dey, S.K., Lim, H., Das, S.K., Reese, J., Paria, B.C., Daikoku, T. & Wang, H.B. (2004). Molecular cues to implantation. Endocr. Rev. 25, 341–73.
Halachmi, S., Marden, E., Martin, G., MacKay, H., Abbondanza, C. & Brown, M. (1994). Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. Science 264, 1455–8.
Lessey, B.A., Palomino, W.A., Apparao, K.B.C., Young, S.L. & Lininger, R.A. (2006). Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reprod. Biol. Endocrinol. 4, 29.
Lim, H.J. & Wang, H.B. (2010). Uterine disorders and pregnancy complications: insights from mouse models. J. Clin. Invest. 120, 1004–15.
Linden, H.M., Stekhova, S.A., Link, J.M., Gralow, J.R., Livingston, R.B. & Ellis, G.K. (2006). Quantitative fluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer. J. Clin. Oncol. 24, 2793–9.
Linden, H.M., Kurland, B.F., Peterson, L.M., Schubert, E.K., Gralow, J.R. & Specht, J.M. (2011). Fluoroestradiol positron emission tomography reveals differences in pharmaco-dynamics of aromatase inhibitors, tamoxifen, and fulvestrant in patients with metastatic breast cancer. Clin. Cancer Res. 17, 4799–805.
Ma, W.G., Song, H.S., Das, S.K., Paria, B.C. & Dey, S.K. (2003). Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc. Natl. Acad. Sci. USA 100, 2963–8.
Miura, C., Higashino, T. & Miura, T. (2007). A progestin and an estrogen regulate early stages of oogenesis in fish. Biol. Reprod. 77, 822–8.
Naglera, J.J., Cavileera, T.D., Verduccic, J.S., Schultzd, I.R., Hooke, S.E. & Haytonf, W.L. (2012). Estrogen receptor mRNA expression patterns in the liver and ovary of female rainbow trout over a complete reproductive cycle. Gen. Comp. Endocrinol. 178, 556–61.
Ng, E.H.Y., Lau, E.Y.L., Yeung, W.S.B. & Ho, P.C. (2001). HMG is as good as recombinant human FSH in terms of oocyte and embryo quality: a prospective randomized trial. Hum. Reprod. 16, 319–25.
Palstra, A.P., Schnabel, D., Nieveen, M.C. & Spaink, H.P. (2010). Temporal expression of hepatic estrogen receptor 1, vitellogenin1 and vitellogenin2 in European silver eels. Gen. Comp. Endocrinol. 166, 111.
Simón, C., Velasco, J.G., Valbuena, D., Peinado, J.A., Moreno, C., Remohí, J. & Pellicer, A. (1998). Increasing uterine receptivity by decreasing estradiol levels during the preimplantation period in high responders with the use of a follicle-stimulating hormone step-down regimen. Fertil. Steril. 70, 234–9.
Vitt, U.A., Hayashi, M., Klein, C. & Hsueh, A.J.W. (2000). Growth differentiation factor-9 stimulates proliferation but suppresses the follicle-stimulating hormone-induced differentiation of cultured granulosa cells from small antral and preovulatory rat follicles. Biol. Reprod. 62, 370–7.
Wang, H.B. & Dey, S.K. (2006). Roadmap to embryo implantation: clues from mouse models. Nat. Rev. Genet. 7, 185–99.
Wang, H.B., Guo, Y., Wang, D.Z., Kingsley, P.J., Marnett, L.J., Das, S.K., DuBois, R. & Dey, S.K. (2004). Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat. Med. 10, 1074–80.

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