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Uptake, Translocation, and Metabolism of MG-191 Safener in Corn (Zea Mays L.)

Published online by Cambridge University Press:  12 June 2017

István Jablonkai  and
Ferenc Dutka
István Jablonkai
Affiliation:
Dep. for Pestic. Res., Central Res. Inst. for Chemistry, Hungarian Academy of Sciences, P.O. Box 17, H-1525 Budapest, Hungary
Ferenc Dutka
Affiliation:
Dep. for Pestic. Res., Central Res. Inst. for Chemistry, Hungarian Academy of Sciences, P.O. Box 17, H-1525 Budapest, Hungary
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Abstract

The time-dependent uptake, translocation, and metabolism of [14C]MG-191 safener and the influence of EPTC on these processes were studied using 5-d-old corn seedlings grown in nutrient solution. Plants absorbed relatively low levels of root-applied radiolabel at both 10 μM and 50 μM [14C]MG-191 rates during 6 d of exposure. Amounts of absorbed radioactivity increased with time. Addition of 50 μM EPTC, in general, did not alter amounts of [14C]MG-191 taken up. Initial translocation of radiolabel from roots to shoots was more rapid at 10 μM [14C]MG-191 treatment compared to 50 μM. EPTC had no effect on radiolabel movement at either safener rate. MG-191 was metabolized rapidly to water-soluble metabolites. Slower formation of water-soluble products was detected only during the initial 3 h in the presence of EPTC. Also, thin-layer chromatographic analyses of water- and hexane-soluble metabolite fractions confirmed rapid transformation of the parent molecule. Because addition of EPTC retarded parent MG-191 metabolism 3 h after treatment, we assume that initial availability of the MG-191 molecule may be prerequisite to its protective effect.

Keywords

MG-191,2-dichloromethyl-2-methyl-1,3-dioxolaneEPTC, S-ethyl dipropylthiocarbamatecorn, Zea mays L. ‘Pioneer 3737.’MG-191EPTCsafener
Type
Physiology, Chemistry, and Biochemistry
Information
Weed Science , Volume 43 , Issue 2 , June 1995 , pp. 169 - 174
Copyright
Copyright © 1995 by the Weed Science Society of America 

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References

LITERATURE CITED

1. Breaux, E. J., Hoobler, M. A., Patanella, J. E., and Leyes, G. A. 1983. Mechanism of action of thiazole safeners. Pages 163–175 in Hatzios, K. K. and Hoagland, R. E., eds. Crop Safeners for Herbicides: Development, Uses, and Mechanism of Action. Academic Press, San Diego, CA.Google Scholar
2. Dutka, F. and Komives, T. 1983. On the mode of action of EPTC and its antidotes. Pages 213–218 in Miyamoto, J. and Kearney, P. C., eds. Pesticide Chemistry: Human Welfare and the Environment. Vol 3, Pergamon Press, Oxford, UK.Google Scholar
3. Dutka, F. and Komives, T. 1987. MG-191: a new selective herbicide antidote. Pages 201–204 in Greenhalgh, R. and Roberts, T. R., eds. Pesticide Science and Biotechnology. Blackwell, Oxford, UK.Google Scholar
4. Dutka, F., Komives, T., Söptei, Cs., and Tömördi, E. 1987. MG-191—a new selective herbicide antidote. Proc. British Crop Prot. Conf.—Weeds. 1:77–84.Google Scholar
5. Dutka, F. 1987. Chemical reactivity—biological activity relationship: Rational strategy for development of bioactive compounds. Proc. Conf. of Hungarian Chem. (Vegyeszkonferencia), Debrecen, Hungary, Program: 9.Google Scholar
6. Dutka, F. 1991. Bioactive chemical bond systems. Z. Naturforsch. 46c:805–809.CrossRefGoogle Scholar
7. Ekler, Z. and Dutka, F. 1991. Chemical reactivity and safener activity of acetal compounds. Z. Naturforsch. 46c:810–814.CrossRefGoogle Scholar
8. Fuerst, E. P. 1987. Understanding the mode of action of the chloroacetanilide and thiocarbamate herbicides. Weed Technol. 1:270–277.CrossRefGoogle Scholar
9. Halpert, J. E., Balfour, C., Miller, N. E., and Kaminsky, L. S. 1986. Dichloromethyl compounds as mechanism-based in activators of rat liver cytochrome P-450 in vitro. Mol. Pharmacol. 30:19–24.Google ScholarPubMed
10. Hatzios, K. K. 1989. Mechanism of action of herbicide safeners: An overview. Pages 65–101 in Hatzios, K. K. and Hoagland, R. E., eds. Crop Safeners for Herbicides: Development, Uses, and Mechanism of Action. Academic Press, San Diego, CA.CrossRefGoogle Scholar
11. Jablonkai, I. and Dutka, F. 1990. Synthesis of 2-dichloromethyl-2-methyl-[14C]-1,3-dioxolane. Radiochem. Nucl. Chem., Letters 144:173–177.CrossRefGoogle Scholar
12. Jablonkai, I. and Dutka, F. 1991. Effect of the site of MG-191 application on acetochlor herbicide uptake, distribution and phytotoxicity. Pest. Sci. 31:91–93.Google Scholar
13. Jablonkai, I. 1991. Basis for differential chemical selectivity of MG-191 safener against acetochlor and EPTC injury to maize. Z. Naturforsch. 46c:836–845.CrossRefGoogle Scholar
14. Jablonkai, I. and Hatzios, K. K. 1994. Microsomal oxidation of the herbicides EPTC and acetochlor and of the safener MG-191 in maize. Pestic. Biochem. Physiol. 48:98–109.CrossRefGoogle Scholar
15. Komives, T. and Dutka, F. 1989. Effects of herbicide safeners on levels and activity of cytochrome P-450 and other enzymes of corn. Pages 129–145 in Hatzios, K. K. and Hoagland, R. E., eds. Crop Safeners for Herbicides: Development, Uses, and Mechanisms of Action. Academic Press, Inc., New York.CrossRefGoogle Scholar
16. Kulkarni, A. P. and Hodgson, E. 1980. Metabolism of insecticides by mixed function oxidase system. Pharmacol. Ther. 8:379–475.CrossRefGoogle Scholar
17. Kuramshin, E. M., Kulak, L. G., Nazarov, M. N., Zlotinskii, S. S., and Rakhmankulov, D. L. 1989. Oxidation of cyclic acetals as a preparative method of diol monoester production. J. Pract. Chem. 331:591–599.CrossRefGoogle Scholar
18. Miaullis, J. B., Thomas, V. M., Gray, R. A., Murphy, J. J., and Hollingworth, R. M. 1978. Metabolism of R-25788 (N,N-diallyl-2,2-dichloroacetamide) in corn plants, rats and soil. Pages 109–131 in Pallos, F. M. and Casida, J. E., eds. Chemistry and Action of Herbicide Antidotes. Academic Press, New York.CrossRefGoogle Scholar
19. Stephenson, G. R. and Chang, F. Y. 1978. Comparative activity and selectivity of herbicide antidotes. Pages 35–61 in Pallos, F. M. and Casida, J. E., eds. Chemistry and Action of Herbicide Antidotes. Academic Press, New York.CrossRefGoogle Scholar
20. Szell, E., Csala, I., Fodor, F., Komives, T., and Dutka, F. 1985. Comparative study of a new class of herbicide antidote. Cereal Res. Comm. 13:55–61.Google Scholar
21. Yenne, S. P., Hatzios, K. K., and Meredith, S. A. 1990. Uptake, translocation, and metabolism of oxabetrinil and CGA-133205 in grain sorghum (Sorghum bicolor) and their influence on metolachlor metabolism. J. Agric. Food Chem. 38:1957–1961.CrossRefGoogle Scholar