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Pyridazocidin, a new microbial phytotoxin with activity in the Mehler reaction

Published online by Cambridge University Press:  12 June 2017

B. Clifford Gerwick ,
Stephen S. Fields ,
Paul R. Graupner ,
James A. Gray ,
Eleanor L. Chapin ,
John A. Cleveland  and
Dale R. Heim
B. Clifford Gerwick*
Affiliation:
DowElanco, 9330 Zionsville Road, Indianapolis, IN 46268
Stephen S. Fields
Affiliation:
DowElanco, Indianapolis, IN 46268
Paul R. Graupner
Affiliation:
DowElanco, Indianapolis, IN 46268
James A. Gray
Affiliation:
DowElanco, Indianapolis, IN 46268
Eleanor L. Chapin
Affiliation:
DowElanco, Indianapolis, IN 46268
John A. Cleveland
Affiliation:
DowElanco, Indianapolis, IN 46268
Dale R. Heim
Affiliation:
DowElanco, Indianapolis, IN 46268
*
cgerwick@dowelanco.com.
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Abstract

A new phytotoxin, pyridazocidin, was produced in shake-flask cultures of a Streptomyces sp. soil isolate. A combination of solvent partitioning, size-exclusion chromatography, and high-pressure liquid chromatography (HPLC) was used to isolate the material. The structure was assigned based on mass spectroscopy and nuclear magnetic resonance (NMR) experiments. Greenhouse evaluations indicated rapid necrosis and chlorosis of treated weeds, particularly of giant foxtail. Isolated chloroplasts consumed oxygen in the presence of pyridazocidin over a concentration range also inhibiting plant growth. Pyridazocidin represents the first reported natural product that appears to act via reversible oxidation/reduction linked to photosynthetic electron transport.

Keywords

Giant foxtailSetaria faberi HerrmSETFANatural productSETFA
Type
Physiology, Chemistry, and Biochemistry
Information
Weed Science , Volume 45 , Issue 5 , October 1997 , pp. 654 - 657
Copyright
Copyright © 1997 by the Weed Science Society of America 

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