Skip to main content Accessibility help
×
Home

Topography of long- and middle-wavelength sensitive cone opsin gene expression in human and Old World monkey retina

  • MAUREEN NEITZ (a1), SHAWN D. BALDING (a1), CARRIE MCMAHON (a1), STACY A. SJOBERG (a1) and JAY NEITZ (a1)...

Abstract

The topographical distributions of the relative ratio of long- (L) and middle- (M) wavelength sensitive cone opsin messenger RNA (mRNA) in human and baboon retinas were mapped using real-time polymerase chain reaction. The L:M mRNA ratio increased in a central-to-peripheral gradient in both species, being quite pronounced for humans.

Copyright

Corresponding author

Address correspondence and reprint requests to: Maureen Neitz, Department of Ophthalmology, The Eye Institute, 925 North 87th Street, Milwaukee, WI 53226. E-mail: mneitz@mcw.edu

References

Hide All

REFERENCES

Ahnelt, P.K., Kolb, H., & Pflug, R. (1987). Identification of a subtype of cone photoreceptor, likely to be blue sensitive, in the human retina. The Journal of Comparative Neurology 255, 1834.
Ahnelt, P.K., Fernández, E., Martinez, O., & Kübber-Heiss, A. (2000). Irregular S-cone mosaics in felid retinas. Spatial interactions with axonless horizontal cells, revealed by cross correlation. J. Optical Society of America A 17, 581588.
Bollinger, K., Bialozynski, C., Neitz, J., & Neitz, M. (2001). The importance of deleterious mutations of M pigment genes as a cause of color vision defects. Color Research and Application 26, S100S105.
Bollinger, K., Sjoberg, S., Neitz, M., & Neitz, J. (2004). Topographical cone photopigment gene expression in deutan-type red-green color vision defects. Vision Research 34, 134145.
Bowmaker, J.K., Parry, J.W.L., & Mollon, J.D. (2003). The arrangement of L and M cones in human and a primate retina. In Normal and Defective Colour Vision, eds. Mollon, J.D., Pokorny, J. & Knoblauch, K., pp. 3950. Oxford University Press, New York.
Bumsted, K. & Hendrickson, A. (1999). Distribution and development of short-wavelength cones differ between Macaca monkey and human fovea. Journal of Comparative Neurology 403, 502516.
Bumsted, K., Jasoni, C., Szel, A., & Hendrickson, A. (1997). Spatial and temporal expressions of cone opsins during monkey retinal development. Journal of Comparative Neurology 378, 117134.
Carroll, J., Neitz, M., & Neitz, J. (2002). Estimates of L:M cone ratio from ERG flicker photometry and genetics. Journal of Vision 2, 531542.
Curcio, C.A., Allen, K.A., Sloan, K.R., Lerea, C.L., Hurley, J.B., Klock, I.B., & Milam, A.H. (1991). Distribution and morphology of human cone photoreceptors stained with anti-blue opsin. The Journal of Comparative Neurology 312, 610624.
Deeb, S.S., Diller, L.C., Williams, D.R., & Dacey, D.M. (2000). Interindividual and topographical variation of L:M cone ratios in monkey retinas. Journal of the Optical Society of America A 17, 538544.
Diller, L., Packer, O.S., Verweij, J., McMahon, M.J., Williams, D.R., & Dacey, D.M. (2004). L and M cone contributions to the midget and parasol ganglion cell receptive fields of macaque monkey retina. Journal of Neuroscience 24, 10791088.
Hagstrom, S.A., Neitz, J., & Neitz, M. (1998). Variations in cone populations for red-green color vision examined by analysis of mRNA. NeuroReport 9, 19631967.
Hagstrom, S.A., Neitz, M., & Neitz, J. (2000). Cone pigment gene expression in individual photoreceptors and the chromatic topography of the retina. Journal of the Optical Society of America A 17, 527537.
Hofer, H., Carroll, J., Neitz, J., Neitz, M., & Williams, D.R. (2005). Organization of the human trichromatic cone mosaic. Journal of Neuroscience 25, 96699679.
LaVail, M.M., Rapaport, D.H., & Rakic, P. (1991). Cytogenesis in the monkey retina. Journal of Comparative Neurology 309, 86114.
Lee, B.B. (2004). Paths to colour in the retina. Clinical and Experimental Optometry 87, 239248.
Lennie, P., Haake, P.W., & Williams, D.R. (1991). The design of chromatically opponent receptive fields. In Computational Models of Visual Processing, eds. Landy, M.S. & Movshon, J.A., pp. 7182. MIT Press, Cambridge.
Marc, R.E. & Sperling, H.G. (1977). Chromatic organization of primate cones. Science 196, 454456.
Martin, P.R. & Grunert, U. (1999). Analysis of the short wavelength-sensitive (“blue”) cone mosaic in the primate retina: Comparison of New World and Old World monkeys. Journal of Comparative Neurology 406, 114.
Martin, P.R., Grunert, U., Chan, T.L., & Bumsted, K. (2000). Spatial order in short-wavelength-sensitive cone photoreceptors: A comparative study of the primate retina. Journal of the Optical Society of America 17, 557579.
Martin, P.R., Lee, B.B., White, A.J.R., Solomon, S.G., & Ruttiger, L. (2001). Chromatic sensitivity of ganglion cells in the peripheral primate retina. Nature 410, 933936.
Mollon, J.D. & Bowmaker, J.K. (1992). The spatial arrangement of cones in the primate fovea. Nature 360, 677679.
Nathans, J. (1999). The evolution and physiology of human color vision: Insights from molecular genetic studies of visual pigments. Neuron 24, 299312.
Nathans, J., Davenport, C.M., Maumenee, I.H., Lewis, R.A., Hejtmancik, J.F., Litt, M., Lovrien, E., Weleber, R., Bachynski, B., Zwas, F., Klingaman, R., & Fishman, G. (1989). Molecular genetics of blue cone monochromacy. Science 245, 831838.
Neitz, M., Kraft, T.W., & Neitz, J. (1998). Expression of L cone pigment gene subtypes in females. Vision Research 38, 32213225.
Neitz, M. & Neitz, J. (2001). A new test for mass screening of school age children for red-green color vision defects. Color Research & Application 26, S239S249.
Reese, B.E., Necessary, B.D., Tam, P.P., Faulkner-Jones, B., & Tan, S.S. (1999). Clonal expansion and cell dispersion in the developing mouse retina. European Journal of Neuroscience 11, 29652978.
Reese, B.E. & Tan, S.S. (1998). Clonal boundary analysis in the developing retina using X-inactivation transgenic mosaic mice. Seminars in Cell & Developmental Biology 9, 285292.
Reid, R.C. & Shapely, R.M. (1992). Spatial structure of cone inputs to receptive fields in primate lateral geniculate nucleus. Nature 356, 716718.
Ringrose, L. & Paro, R. (2004). Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annual Review Genetics 38, 413443.
Roorda, A., Metha, A., Lennie, P., & Williams, D.R. (2001). Packing arrangement of the three cone classes in primate retina. Vision Research 41, 12911306.
Roorda, A. & Williams, D.R. (1999). The arrangement of the three cone classes in the living human eye. Nature 397, 520522.
Smallwood, P.M., Wang, Y., & Nathans, J. (2002). Role of a locus control region in the mutually exclusive expression of human red and green cone pigment genes. PNAS 99, 10081011.
Solomon, S.G., Lee, B.B., White, A.J., Ruttiger, L., & Martin, P.R. (2005). Chromatic organization of ganglion cell receptive fields in the peripheral retina. Journal of Neuroscience 25, 45274539.
Wang, Y., Macke, J.P., Merbs, S.L., Zack, D.J., Klaunberg, B., Bennett, J., Gearhart, J., & Nathans, J. (1992). A locus control region adjacent to the human red and green visual pigment genes. Neuron 9, 429440.
Wang, Y., Smallwood, P.M., Cowan, M., Blesh, D., Lawler, A., & Nathans, J. (1999). Mutually exclusive expression of human red and green visual pigment-reporter transgenes occurs at high frequency in murine cone photoreceptors. Proceedings of the National Academy of Sciences, U.S.A. 96, 52515256.
Wikler, K.C. & Rakic, P. (1990). Distribution of photoreceptor subtypes in the retina of diurnal and nocturnal primates. The Journal of Neuroscience 10, 33903401.
Winderickx, J., Battisti, L., Motulsky, A.G., & Deeb, S.S. (1992). Selective expression of human X chromosome-linked green opsin genes. Proceedings of the National Academy of Sciences USA 89, 97109714.
Xiao, M. & Hendrickson, A. (2000). Spatial and temporal expression of short, long/medium or both opsins in human fetal cones. Journal of Comparative Neurology 425, 545559.

Keywords

Topography of long- and middle-wavelength sensitive cone opsin gene expression in human and Old World monkey retina

  • MAUREEN NEITZ (a1), SHAWN D. BALDING (a1), CARRIE MCMAHON (a1), STACY A. SJOBERG (a1) and JAY NEITZ (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed