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Platelet-derived growth factor (PDGF) receptors in the developing mouse optic pathway

Published online by Cambridge University Press:  02 June 2009

James B. Hutchins  and
Xiaorong Zhang
James B. Hutchins
Affiliation:
Departments of Anatomy and Neurology, University of Mississippi Medical Center, Jackson
Xiaorong Zhang
Affiliation:
Department of Anatomy, University of Mississippi Medical Center, Jackson
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Abstract

The molecules which control the patterns of cell division, growth, and precise interconnections characteristic of the central nervous system still remain largely unidentified. The protein platelet-derived growth factor (PDGF) has been shown to mediate interactions among glial cells in vitro. More recent evidence has indicated that PDGF may also be involved in controlling communication between neurons and glial cells and among neurons. The presence of receptors for PDGF on neurons of the developing nervous system is an essential piece of evidence in this chain of events. Ganglion cells are labeled with antibodies to PDGF receptor only during the period of active process outgrowth. These findings suggest that PDGF is used as a mediator of intercellular signaling during neuronal development.

Keywords

Proto-oncogenesRetinaOptic nerveOptic chiasmTyrosine kinases
Type
Research Articles
Information
Visual Neuroscience , Volume 11 , Issue 1 , January 1994 , pp. 33 - 40
Copyright
Copyright © Cambridge University Press 1994

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