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Initial tracking conditions modulate the gain of visuo-motor transmission for smooth pursuit eye movements in monkeys

  • Joshua D. Schwartz (a1) and Stephen G. Lisberger (a1)


Smooth pursuit eye movements allow primates to keep gaze pointed at small objects moving across stationary surroundings. In monkeys trained to track a small moving target, we have injected brief perturbations of target motion under different initial conditions as probes to read out the state of the visuo-motor pathways that guide pursuit. A large eye movement response was evoked if the perturbation was applied to a moving target the monkey was tracking. A small response was evoked if the same perturbation was applied to a stationary target the monkey was fixating. The gain of the response to the perturbation increased as a function of the initial speed of target motion and as a function of the interval from the onset of target motion to the time of the perturbation. The response to the perturbation also was direction selective. Gain was largest if the perturbation was along the axis of ongoing target motion and smallest if the perturbation was orthogonal to the axis of target motion. We suggest that two parallel sets of visual motion pathways through the extrastriate visual cortex may mediate, respectively, the visuo-motor processing for pursuit and the modulation of the gain of transmission through those pathways.



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Allman, J., Miezin, F. & McGuinness, E. (1985). Direction- and velocity-specific responses from beyond the classical receptive field in the middle temporal visual area (MT). Perception 14, 105126.
Brodal, P. (1978). The corticopontine projection in the rhesus monkey: Origin and principles of organization. Brain 101, 251283.
Brodal, P. (1979). The pontocerebellar projection in the rhesus monkey: An experimental study with retrograde axonal transport of horseradish peroxidase. Neuroscience 4, 193208.
Brodal, P. (1982). Further observations on the cerebellar projections from the pontine nucleus and the nucleus reticularis pontis in the rhesus monkey. Journal of Comparative Neurology 204, 4455.
Bruce, C.J., Goldberg, M.E., Bushnell, M.C. & Stanton, G.B. (1985). Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. Journal of Neurophysiology 54, 714734.
Dursteler, M.R. & Wurtz, R.H. (1988). Pursuit and optokinetic deficits following chemical lesions of cortical areas MT and MST. Journal of Neurophysiology 60, 940965.
Dursteler, M.R., Wurtz, R.H. & Newsome, W.T. (1987). Directional pursuit deficits following lesions of the foveal representation within the superior temporal sulcus of the macaque monkey. Journal of Neurophysiology 57, 12621287.
Fries, W. (1981). The projection from striate and prestriate visual cortex onto the pontine nuclei in the macaque monkey. Society for Neuroscience Abstracts 7, 762.
Gerrits, N.M. & Voogd, J. (1989). The topographical organization of climbing and mossy fiber afferents in the flocculus and ventral para-flocculus in the rabbit, cat, and monkey. Experimental Brain Research (Suppl.) 17, 2629.
Glickstein, M., Cohen, J.L., Dixon, B., Gibson, A., Hollins, M., LaBossiere, E. & Robinson, F. (1980). Corticopontine visual projections in macaque monkeys. Journal of Comparative Neurology 190, 209229.
Glickstein, M., May, J. & Mercer, B.E. (1985). Corticopontine projection in the macaque: The distribution of labelled cortical cells after large injections of horseradish peroxidase in the pontine nuclei. Journal of Comparative Neurology 235, 343359.
Goldreich, D., Krauzlis, R.J. & Lisberger, S.G. (1992). Effect of changing feedback delay on spontaneous oscillations in smooth pursuit eye movements of monkeys. Journal of Neurophysiology 67, 625638.
Grasse, K.L. & Lisberger, S.G. (1992). Analysis of a naturally occurring asymmetry in vertical smooth pursuit eye movement in a monkey. Journal of Neurophysiology 67, 164179.
Judge, S.G., Richmond, B.J. & Chu, F.C. (1980). Implantation of magnetic search coils for measurement of eye position. Vision Research 20, 535538.
Keating, E.G. (1991). Frontal eye field lesions impair predictive and visually-guided pursuit eye movements. Experimental Brain Research 86, 311323.
Komatsu, H. & Wurtz, R.H. (1989). Modulation of pursuit eye movements by stimulation of cortical areas MT and MST. Journal of Neurophysiology 62, 3147.
Lisberger, S.G., Morris, E.J. & Tychsen, L. (1987). Visual motion processing and sensory-motor integration for smooth pursuit eye movements. Annual Review of Neuroscience 10, 97129.
Lisberger, S.G. & Westbrook, L.E. (1985). Properties of visual input that initiate horizontal smooth pursuit eye movements in monkeys. Journal of Neuroscience 5, 16621673.
Luebke, A.E. & Robinson, D.A. (1988). Transition dynamics between pursuit and fixation suggest different systems. Vision Research 28, 941946.
Lynch, J.C. (1987). Frontal eye field lesions in monkeys disrupt pursuit. Experimental Brain Research 68, 437441.
MacAvoy, M.G., Gottlieb, J.P. & Bruce, C.J. (1991). Smooth pur-suit eye movement representation in the primate frontal eye field. Cerebral Cortex 1, 95102.
May, J.G., Keller, E.L. & Crandall, W.F. (1986). Changes in eye velocity during smooth pursuit tracking induced by microstimulation in the dorsolateral pontine nucleus of the macaque. Experimental Brain Research 63, 265278.
McKee, S.P. (1981). A local mechanism for differential velocity detection. Vision Research 21, 491500.
Miles, F.A. & Eighmy, B.B. (1980). Long-term adaptive changes in the primate vestibulo-ocular reflex. I. Behavioral observations. Journal of Neurophysiology 43, 14061425.
Morris, E.J. & Lisberger, S.G. (1987). Different responses to small visual errors during initiation and maintenance of smooth-pursuit eye movements in monkeys. Journal of Neurophysiology 58, 13511369.
Mustari, M.J., Fuchs, A.F. & Wallman, J. (1988). Response properties of dorsolateral pontine units during smooth pursuit in the rhesus macaque. Journal of Neurophysiology 60, 664686.
Newsome, W.T., Wurtz, R.H., Dursteler, M.R. & Mikami, A. (1985). Deficits in visual motion processing following ibotenic acid lesions of the middle temporal visual area of the macaque monkey. Journal of Neuroscience 5, 825840.
Newsome, W.T., Wurtz, R.H. & Komatsu, H. (1988). Relation of cortical areas MT and MST to pursuit eye movements. II. Differentiation of retinal from extraretinal inputs. Journal of Neurophysiology 60, 604620.
Rashbass, C. (1961). The relationship between saccadic and smooth tracking eye movements. Journal of Physiology (London) 159, 326338.
Robinson, D. (1965). The mechanics of human smooth pursuit eye movement. Journal of Physiology (London) 180, 569591.
Robinson, D.A., Gordon, J.L. & Gordon, S.E. (1986). A model of the smooth pursuit eye movement system. Biological Cybernetics 55, 4357.
Stone, L.S. & Lisberger, S.G. (1990). Visual responses of Purkinje cells in the cerebellar flocculus during smooth-pursuit eye movements in monkeys. I. Simple spikes. Journal of Neurophysiology 63, 12411261.
Suzuki, D.A. & Keller, E.L. (1984). Visual signals in the dorsolateral pontine nucleus of the alert monkey: Their relationship to smooth-pursuit eye movements. Experimental Brain Research 53, 473478.
Suzuki, D.A., May, J. & Keller, E.L. (1988). Smooth-pursuit eye movement deficits with chemical lesions in the dorsolateral pontine nucleus of the monkey. Journal of Neurophysiology 59, 952977.
Thiers, P., Koehler, W. & Buettner, U.W. (1988). Neuronal activity in the dorsolateral pontine nucleus of the alert monkey modulated by visual stimuli and eye movements. Brain Research 72, 496512.
Wurtz, R.H. (1969). Visual receptive fields of striate cortex neurons in awake monkeys. Journal of Neurophysiology 32, 727742.
Wurtz, R.H., Richmond, B.J. & Newsome, W.T. (1984). Modulation of cortical visual processing by attention. In Dynamic Aspects of Neocortical Function, ed. Edelman, G.M., Gall, W.E. & Cowan, W.M., p. 195. New York: Wiley.
Zee, D.S., Yamazaki, A., Butler, P.H. & Gucer, G. (1981). Effects of ablation of the flocculus and paraflocculus on eye movements in the primate. Journal of Neurophysiology 46, 878899.


Initial tracking conditions modulate the gain of visuo-motor transmission for smooth pursuit eye movements in monkeys

  • Joshua D. Schwartz (a1) and Stephen G. Lisberger (a1)


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