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Endocannabinoid signaling regulates spontaneous transmitter release from embryonic retinal amacrine cells

Published online by Cambridge University Press:  11 April 2007

AJITHKUMAR WARRIER  and
MARTIN WILSON
AJITHKUMAR WARRIER
Affiliation:
Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences, Davis, California
MARTIN WILSON
Affiliation:
Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences, Davis, California
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Abstract

GABAergic amacrine cells, cultured from embryonic chick retina, display spontaneous mini frequencies ranging from 0–4.6 Hz as a result of the release of quanta of transmitter from both synapses and autapses. We show here that at least part of this variation originates from differences in the degree to which endocannabinoids, endogenously generated within the culture, are present at terminals presynaptic to individual cells. Though all cells examined scored positive for cannabinoid receptor type I (CB1R), only those showing a low initial rate of spontaneous minis responded to CB1R agonists with an increase in mini frequency, caused by a Gi/o-mediated reduction in [cAMP]. Cells displaying a high initial rate of spontaneous minis, on the other hand, were unaffected by CB1R agonists, but they did show a rate decrease with CB1R antagonists. Such a regulation of spontaneous transmitter release by endocannabinoids might be important in network maintenance in amacrine cells and other inhibitory interneurons.

Keywords

RetinaAmacrine cellEndocannabinoidCB1RSpontaneous mini frequency
Type
Research Article
Information
Visual Neuroscience , Volume 24 , Issue 1 , January 2007 , pp. 25 - 35
Copyright
© 2007 Cambridge University Press

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