Skip to main content Accessibility help
×
×
Home

Variance Components Models for Physical Activity With Age as Modifier: A Comparative Twin Study in Seven Countries

  • Jacqueline M. Vink (a1), Dorret I. Boomsma (a2), Sarah E. Medland (a3), Marleen H. M. de Moor (a4), Janine H. Stubbe (a5), Belinda K. Cornes (a6), Nicholas G. Martin (a7), Axel Skytthea (a8), Kirsten O. Kyvik (a9), Richard J. Rose (a10), Urho M. Kujala (a11), Jaakko Kaprio (a12), Jennifer R. Harris (a13), Nancy L. Pedersen (a14), Lynn Cherkas (a15), Tim D. Spector (a16) and Eco J. C. de Geus (a17)...

Abstract

Physical activity is influenced by genetic factors whose expression may change with age. We employed an extension to the classical twin model that allows a modifier variable, age, to interact with the effects of the latent genetic and environmental factors. The model was applied to self-reported data from twins aged 19 to 50 from seven countries that collaborated in the GenomEUtwin project: Australia, Denmark, Finland, Norway, Netherlands, Sweden and United Kingdom. Results confirmed the importance of genetic influences on physical activity in all countries and showed an age-related decrease in heritability for 4 countries. In the other three countries age did not interact with heritability but those samples were smaller or had a more restricted age range. Effects of shared environment were absent, except in older Swedish participants. The study confirms the importance of taking age effects into account when exploring the genetic and environmental contribution to physical activity. It also suggests that the power of genome-wide association studies to identify the genetic variants contributing to physical activity may be larger in young adult cohorts.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Variance Components Models for Physical Activity With Age as Modifier: A Comparative Twin Study in Seven Countries
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Variance Components Models for Physical Activity With Age as Modifier: A Comparative Twin Study in Seven Countries
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Variance Components Models for Physical Activity With Age as Modifier: A Comparative Twin Study in Seven Countries
      Available formats
      ×

Copyright

Corresponding author

*Address for correspondence: Jacqueline M. Vink, Department of Biological Psychology, VU University, Van der Boechorststraat 1, The Netherlands, 1081 BT Amsterdam.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed