Recent plans to establish a Twinsburg Research Institute in Twinsburg, Ohio, home of the annual Twins Days Festival, are reviewed. Included among the topics under discussion were the development of an Ohio and/or national United States twin registry and the appropriate location for such a facility. Next, recent findings on chromosomal anomalies and other adverse consequences of artificial reproduction are summarized — some results are surprising and unexplained. This information is followed by further examination of epigenetic twin studies, supplementing a review in a previous issue. The last section of this article presents insightful material about twin leaders, scholars, athletes, designers and parents.